Zobrazeno 1 - 10
of 62
pro vyhledávání: '"lung exposure"'
Autor:
Angela J. T. Bosch, Theresa V. Rohm, Shefaa AlAsfoor, Andy J. Y. Low, Lena Keller, Zora Baumann, Neena Parayil, Marc Stawiski, Leila Rachid, Thomas Dervos, Sandra Mitrovic, Daniel T. Meier, Claudia Cavelti-Weder
Publikováno v:
Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Air pollution has emerged as an unexpected risk factor for diabetes. However, the mechanism behind remains ill-defined. So far, the lung has been considered as the main target organ of air pollution. In contrast, the gut has recei
Externí odkaz:
https://doaj.org/article/69c058265092496881f3beb53d3725e0
Autor:
Jia Liu, Furun Wang, Xi Wang, Shiyong Fan, Yufeng Li, Mingyue Xu, Hengrui Hu, Ke Liu, Bohong Zheng, Lingchao Wang, Huanyu Zhang, Jiang Li, Wei Li, Wenpeng Zhang, Zhihong Hu, Ruiyuan Cao, Xiaomei Zhuang, Manli Wang, Wu Zhong
Publikováno v:
MedComm, Vol 4, Iss 1, Pp n/a-n/a (2023)
Abstract Tetrandrine (TET) has been used to treat silicosis in China for decades. The aim of this study was to facilitate rational repurposing of TET against SARS‐CoV‐2 infection. In this study, we confirmed that TET exhibited antiviral potency a
Externí odkaz:
https://doaj.org/article/f1e2badab71e469f8b52890656e74499
Autor:
Line Bjerregaard Stick, Ebbe Laugaard Lorenzen, Esben Svitzer Yates, Carmel Anandadas, Karen Andersen, Cynthia Aristei, Orla Byrne, Sandra Hol, Ingelise Jensen, Anna M. Kirby, Youlia M. Kirova, Livia Marrazzo, Angela Matías-Pérez, Mette Marie Bruun Nielsen, Henrik Dahl Nissen, Sileida Oliveros, Karolien Verhoeven, Johan Vikström, Birgitte Vrou Offersen
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 27, Iss , Pp 126-131 (2021)
Background and purpose: Adjuvant radiotherapy of internal mammary nodes (IMN) improves survival in high-risk early breast cancer patients but inevitably leads to more dose to heart and lung. Target coverage is often compromised to meet heart/lung dos
Externí odkaz:
https://doaj.org/article/770aa56d5c8b45afbb10e9fa501919a0
Autor:
Furun Wang, Xue Jiang, Zengxu Yang, Shuang Fu, Shi Yao, Lingchao Wang, Yue Lv, Wenpeng Zhang, Rigao Ding, Xiaomei Zhuang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12948 (2022)
The objective of the present study was to define whether inhaled tetrandrine (TET) could be a promising way to achieve the local effect on its therapeutic efficacy based on biodistribution features using the LPS-treated acute lung injury (ALI) model.
Externí odkaz:
https://doaj.org/article/950073eb0e2a493c872e855509f7c38c
Akademický článek
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Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Henrik Nissen, Youlia M. Kirova, Karen Andersen, S. Hol, K. Verhoeven, L.B. Stick, Cynthia Aristei, Johan Vikström, Livia Marrazzo, Angela Matías-Pérez, Birgitte Vrou Offersen, Orla Byrne, Ingelise Jensen, Mette Marie Bruun Nielsen, Carmel N Anandadas, Sileida Oliveros, E.S. Yates, Anna M. Kirby, Ebbe Laugaard Lorenzen
Publikováno v:
Clinical and Translational Radiation Oncology, 27, 126-131. Elsevier Ireland Ltd
Stick, L B, Lorenzen, E L, Yates, E S, Anandadas, C, Andersen, K, Aristei, C, Byrne, O, Hol, S, Jensen, I, Kirby, A M, Kirova, Y M, Marrazzo, L, Matías-Pérez, A, Nielsen, M M B, Nissen, H D, Oliveros, S, Verhoeven, K, Vikström, J & Offersen, B V 2021, ' Selection criteria for early breast cancer patients in the DBCG proton trial – The randomised phase III trial strategy ', Clinical and Translational Radiation Oncology, vol. 27, pp. 126-131 . https://doi.org/10.1016/j.ctro.2021.01.012
Stick, L B, Lorenzen, E L, Yates, E S, Anandadas, C, Andersen, K, Aristei, C, Byrne, O, Hol, S, Jensen, I, Kirby, A M, Kirova, Y M, Marrazzo, L, Matías-Pérez, A, Nielsen, M M B, Nissen, H D, Oliveros, S, Verhoeven, K, Vikström, J & Offersen, B V 2021, ' Selection criteria for early breast cancer patients in the DBCG proton trial – The randomised phase III trial strategy ', Clinical and translational radiation oncology, vol. 27, pp. 126-131 . https://doi.org/10.1016/j.ctro.2021.01.012
Stick, L B, Lorenzen, E L, Yates, E S, Anandadas, C, Andersen, K, Aristei, C, Byrne, O, Hol, S, Jensen, I, Kirby, A M, Kirova, Y M, Marrazzo, L, Matias-Perez, A, Nielsen, M M B, Nissen, H D, Oliveros, S, Verhoeven, K, Vikstrom, J & Offersen, B V 2021, ' Selection criteria for early breast cancer patients in the DBCG proton trial-The randomised phase III trial strategy ', Clinical and Translational Radiation Oncology, vol. 27, pp. 126-131 . https://doi.org/10.1016/j.ctro.2021.01.012
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, Vol 27, Iss, Pp 126-131 (2021)
Stick, L B, Lorenzen, E L, Yates, E S, Anandadas, C, Andersen, K, Aristei, C, Byrne, O, Hol, S, Jensen, I, Kirby, A M, Kirova, Y M, Marrazzo, L, Matías-Pérez, A, Nielsen, M M B, Nissen, H D, Oliveros, S, Verhoeven, K, Vikström, J & Offersen, B V 2021, ' Selection criteria for early breast cancer patients in the DBCG proton trial – The randomised phase III trial strategy ', Clinical and Translational Radiation Oncology, vol. 27, pp. 126-131 . https://doi.org/10.1016/j.ctro.2021.01.012
Stick, L B, Lorenzen, E L, Yates, E S, Anandadas, C, Andersen, K, Aristei, C, Byrne, O, Hol, S, Jensen, I, Kirby, A M, Kirova, Y M, Marrazzo, L, Matías-Pérez, A, Nielsen, M M B, Nissen, H D, Oliveros, S, Verhoeven, K, Vikström, J & Offersen, B V 2021, ' Selection criteria for early breast cancer patients in the DBCG proton trial – The randomised phase III trial strategy ', Clinical and translational radiation oncology, vol. 27, pp. 126-131 . https://doi.org/10.1016/j.ctro.2021.01.012
Stick, L B, Lorenzen, E L, Yates, E S, Anandadas, C, Andersen, K, Aristei, C, Byrne, O, Hol, S, Jensen, I, Kirby, A M, Kirova, Y M, Marrazzo, L, Matias-Perez, A, Nielsen, M M B, Nissen, H D, Oliveros, S, Verhoeven, K, Vikstrom, J & Offersen, B V 2021, ' Selection criteria for early breast cancer patients in the DBCG proton trial-The randomised phase III trial strategy ', Clinical and Translational Radiation Oncology, vol. 27, pp. 126-131 . https://doi.org/10.1016/j.ctro.2021.01.012
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, Vol 27, Iss, Pp 126-131 (2021)
Highlights • We establish selection criteria for the randomised DBCG Proton Trial. • DBCG proton selection criteria: mean heart dose ≥ 4 Gy and/or lung V17Gy/V20Gy ≥ 37%. • ~1 in 5 patients undergoing loco-regional radiotherapy will be elig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ab4e6c34d01e5346ed170802b071df
https://cris.maastrichtuniversity.nl/en/publications/edd7f490-5dba-40e4-9a3a-59aca6ce3e57
https://cris.maastrichtuniversity.nl/en/publications/edd7f490-5dba-40e4-9a3a-59aca6ce3e57
Autor:
Alice Ban Ke, Lisa Almond, Hannah M. Jones, David Wesche, Mian Zhang, Xian Pan, Karen Rowland Yeo
Publikováno v:
Clinical Pharmacology & Therapeutics
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
We use a mechanistic lung model to demonstrate that accumulation of chloroquine (CQ), hydroxychloroquine (HCQ), and azithromycin (AZ) in the lungs is sensitive to changes in lung pH, a parameter that can be affected in patients with coronavirus disea