Zobrazeno 1 - 10
of 338
pro vyhledávání: '"lung epithelial cell"'
Autor:
Porrnthanate Seenak, Nitirut Nernpermpisooth, Sarawut Kumphune, Worawat Songjang, Arunya Jiraviriyakul, Noppadon Jumroon, Panyupa Pankhong, Sittiruk Roytrakul, Siriwan Thaisakun, Narumon Phaonakrop, Nitra Nuengchamnong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Cigarette smoke (CS) is one of the leading causes of pulmonary diseases and can induce lung secretome alteration. CS exposure-induced damages to human pulmonary epithelial cells and microvascular endothelial cells have been extensively demon
Externí odkaz:
https://doaj.org/article/649b1ba464f44329a7ed0804daa356da
Autor:
Eun Sol Oh, Jae-Won Lee, Yu Na Song, Mun-Ock Kim, Ro Woon Lee, Myung-Ji Kang, Juhyun Lee, Seok Han Yun, Sung-Tae Hong, Hyunju Ro, Su Ui Lee
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39797- (2024)
Background: Tangeretin, a natural polymethoxyflavone compound, possesses potent anti-inflammatory activity that improves respiratory inflammation in chronic obstructive pulmonary disease (COPD). However, the molecular mechanisms underlying the anti-C
Externí odkaz:
https://doaj.org/article/63ccb52751094e5fbca0a8cd94eb3adc
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 389 (2024)
Accumulation of polymyxins in the lung epithelial cells can lead to increased mitochondrial oxidative stress and pulmonary toxicity. Aminoglycosides and polymyxins are used, via intravenous and pulmonary delivery, against multidrug-resistant Gram-neg
Externí odkaz:
https://doaj.org/article/fa6f70439ee749d1a4413a2859567f53
Autor:
Linlin Zhang, Xuanqi Liu, Liyang Li, Bijun Zhu, Zhihong Chen, Jiayun Hou, Yuanlin Song, Xiangdong Wang
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 3, Pp n/a-n/a (2023)
Abstract Background The fundamental initial step in the metabolic process of fatty acids (FA) is facilitated by Acyl‐coenzyme A synthetase (ACS). ACS enables FAs to engage in both anabolic and catabolic pathways by creating thioester bonds with CoA
Externí odkaz:
https://doaj.org/article/5edc096ec4504f219e1c0f2a14c17f31
Akademický článek
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Publikováno v:
环境与职业医学, Vol 39, Iss 6, Pp 708-713 (2022)
Fine particulate matter (PM2.5) has attracted more and more attention in the field of environmental pollution and public health. Previous studies have found that PM2.5 can be inhaled and deposit in the airway and alveoli, and even spread to the whole
Externí odkaz:
https://doaj.org/article/c2441e1e01ba4f3ea8dee886ac70ed1a
Akademický článek
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Akademický článek
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In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19
Autor:
Takaharu Asano, Sarvesh Chelvanambi, Julius L. Decano, Mary C. Whelan, Elena Aikawa, Masanori Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Conventional drug screening methods search for a limited number of small molecules that directly interact with the target protein. This process can be slow, cumbersome and has driven the need for developing new drug screening approaches to counter ra
Externí odkaz:
https://doaj.org/article/c21bb98f16154ccb83ea0e2e2490e710
Autor:
Helena Hernández-Cuervo, Ramani Soundararajan, Sahebgowda Sidramagowda Patil, Mason Breitzig, Matthew Alleyn, Lakshmi Galam, Richard Lockey, Vladimir N. Uversky, Narasaiah Kolliputi
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Acute Lung Injury (ALI), characterized by bilateral pulmonary infiltrates that restrict gas exchange, leads to respiratory failure. It is caused by an innate immune response with white blood cell infiltration of the lungs, release of cytokines, an in
Externí odkaz:
https://doaj.org/article/0e3e6ed22c1f41d8a49d8219c3eafa63