Zobrazeno 1 - 10
of 88
pro vyhledávání: '"luigi racioppi"'
Autor:
William H. Tomaszewski, Jessica Waibl-Polania, Molly Chakraborty, Jonathan Perera, Jeremy Ratiu, Alexandra Miggelbrink, Donald P. McDonnell, Mustafa Khasraw, David M. Ashley, Peter E. Fecci, Luigi Racioppi, Luis Sanchez-Perez, Michael D. Gunn, John H. Sampson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Responses to immune checkpoint blockade (ICB) in patients with glioblastoma are limited. Here the authors show that Calmodulin-Dependent Kinase Kinase 2 (CaMKK2) is expressed in tumor associated macrophages and neurons and is associated with resistan
Externí odkaz:
https://doaj.org/article/d2bad1bc29a045f7afdb7b2e7787b8de
Autor:
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M. Couñago, Brittany Stork, Christopher G. Langendorf, Kevin Nay, Jonathan S. Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R. Means, Brian York, Donald P. McDonnell, John W. Scott, Daniel E. Frigo, David H. Drewry
Publikováno v:
Cells, Vol 12, Iss 2, p 287 (2023)
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a se
Externí odkaz:
https://doaj.org/article/22978372a9134263a1f17e8fa4cfa4d9
Autor:
Wei Huang, Yaping Liu, Anthony Luz, Mark Berrong, Joel N. Meyer, Yujing Zou, Excel Swann, Pasupathi Sundaramoorthy, Yubin Kang, Shekeab Jauhari, William Lento, Nelson Chao, Luigi Racioppi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Myeloid-derived suppressor cells (MDSCs) are a hetero geneous group of cells, which can suppress the immune response, promote tumor progression and impair the efficacy of immunotherapies. Consequently, the pharmacological targeting of MDSC is emergin
Externí odkaz:
https://doaj.org/article/be60ce61da984724af2eac0c24b4959e
Autor:
Luigi Racioppi, Erik R. Nelson, Wei Huang, Debarati Mukherjee, Scott A. Lawrence, William Lento, Anna Maria Masci, Yiquin Jiao, Sunghee Park, Brian York, Yaping Liu, Amy E. Baek, David H. Drewry, William J. Zuercher, Francesca R. Bertani, Luca Businaro, Joseph Geradts, Allison Hall, Anthony R. Means, Nelson Chao, Ching-yi Chang, Donald P. McDonnell
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is highly expressed in several cancers. Here the authors investigate the role of CaMKK2 expression in the tumour microenvironment and show that CaMKK2 expression in tumour-associated macrophages p
Externí odkaz:
https://doaj.org/article/072c9c0330034d37ac61bcbbffebcda1
Autor:
Ennio Carbone, Mario De Felice, Francesca Di Rosa, Ugo D'Oro, Silvia Fontana, Antonio La Cava, Michele Maio, Giuseppe Matarese, Luigi Racioppi, Giuseppina Ruggiero, Giuseppe Terrazzano
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science. The authors discuss how the combination of Serafino Zappacosta's extraordinary commitment to t
Externí odkaz:
https://doaj.org/article/9a6f8c4af9f643d8ae16993299ca1558
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54156 (2013)
The Toll-like receptors represent a largely evolutionarily conserved pathogen recognition machinery responsible for recognition of bacterial, fungal, protozoan, and viral pathogen associated microbial patterns and initiation of inflammatory response.
Externí odkaz:
https://doaj.org/article/6ba30b6c91c1469a8735789f1835ec5e
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29808 (2012)
Pin1 has previously been described to regulate cells that participate in both innate and adaptive immunity. Thus far, however, no role for Pin1 has been described in modulating conventional dendritic cells, innate antigen presenting cells that potent
Externí odkaz:
https://doaj.org/article/66c128f7464b41dc9dcee6fcc412db2c
Autor:
Maria Letizia Giardino Torchia, Elena Ciaglia, Anna Maria Masci, Laura Vitiello, Manuela Fogli, Andrea la Sala, Domenico Mavilio, Luigi Racioppi
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11052 (2010)
BACKGROUND: HIV-1 Protease Inhibitors, namely PIs, originally designed to inhibit HIV-1 aspartic protease, can modulate the immune response by mechanisms largely unknown, and independent from their activity on viral replication. Here, we analyzed the
Externí odkaz:
https://doaj.org/article/a9d6722616f54ba296d6c90ec5def0fb
Autor:
Donald P. McDonnell, Ching-Yi Chang, Laura Akullian D'Agostino, Xia Gao, Sandeep Artham, Debarati Mukherjee, Luigi Racioppi, Patrick K. Juras
Supplementary Figures and Tables: 5 figures, 3 tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543d78854400f78d789057935c73572f
https://doi.org/10.1158/2326-6066.22545867
https://doi.org/10.1158/2326-6066.22545867
Autor:
Donald P. McDonnell, Ching-Yi Chang, Laura Akullian D'Agostino, Xia Gao, Sandeep Artham, Debarati Mukherjee, Luigi Racioppi, Patrick K. Juras
Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a key regulator of energy homeostasis in several cell types. Expression of this enzyme in tumor cells promotes proliferation and migration, and expression in tumor-associated immune cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f3261e47cdca8c8e3f7289bb932fe6
https://doi.org/10.1158/2326-6066.c.6551040
https://doi.org/10.1158/2326-6066.c.6551040