Zobrazeno 1 - 10
of 126
pro vyhledávání: '"luigi racioppi"'
Autor:
William H. Tomaszewski, Jessica Waibl-Polania, Molly Chakraborty, Jonathan Perera, Jeremy Ratiu, Alexandra Miggelbrink, Donald P. McDonnell, Mustafa Khasraw, David M. Ashley, Peter E. Fecci, Luigi Racioppi, Luis Sanchez-Perez, Michael D. Gunn, John H. Sampson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Responses to immune checkpoint blockade (ICB) in patients with glioblastoma are limited. Here the authors show that Calmodulin-Dependent Kinase Kinase 2 (CaMKK2) is expressed in tumor associated macrophages and neurons and is associated with resistan
Externí odkaz:
https://doaj.org/article/d2bad1bc29a045f7afdb7b2e7787b8de
Autor:
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M. Couñago, Brittany Stork, Christopher G. Langendorf, Kevin Nay, Jonathan S. Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R. Means, Brian York, Donald P. McDonnell, John W. Scott, Daniel E. Frigo, David H. Drewry
Publikováno v:
Cells, Vol 12, Iss 2, p 287 (2023)
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a se
Externí odkaz:
https://doaj.org/article/22978372a9134263a1f17e8fa4cfa4d9
Autor:
Wei Huang, Yaping Liu, Anthony Luz, Mark Berrong, Joel N. Meyer, Yujing Zou, Excel Swann, Pasupathi Sundaramoorthy, Yubin Kang, Shekeab Jauhari, William Lento, Nelson Chao, Luigi Racioppi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Myeloid-derived suppressor cells (MDSCs) are a hetero geneous group of cells, which can suppress the immune response, promote tumor progression and impair the efficacy of immunotherapies. Consequently, the pharmacological targeting of MDSC is emergin
Externí odkaz:
https://doaj.org/article/be60ce61da984724af2eac0c24b4959e
Autor:
Luigi Racioppi, Erik R. Nelson, Wei Huang, Debarati Mukherjee, Scott A. Lawrence, William Lento, Anna Maria Masci, Yiquin Jiao, Sunghee Park, Brian York, Yaping Liu, Amy E. Baek, David H. Drewry, William J. Zuercher, Francesca R. Bertani, Luca Businaro, Joseph Geradts, Allison Hall, Anthony R. Means, Nelson Chao, Ching-yi Chang, Donald P. McDonnell
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is highly expressed in several cancers. Here the authors investigate the role of CaMKK2 expression in the tumour microenvironment and show that CaMKK2 expression in tumour-associated macrophages p
Externí odkaz:
https://doaj.org/article/072c9c0330034d37ac61bcbbffebcda1
Autor:
Ennio Carbone, Mario De Felice, Francesca Di Rosa, Ugo D'Oro, Silvia Fontana, Antonio La Cava, Michele Maio, Giuseppe Matarese, Luigi Racioppi, Giuseppina Ruggiero, Giuseppe Terrazzano
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science. The authors discuss how the combination of Serafino Zappacosta's extraordinary commitment to t
Externí odkaz:
https://doaj.org/article/9a6f8c4af9f643d8ae16993299ca1558
Autor:
Donald P. McDonnell, Ching-Yi Chang, Laura Akullian D'Agostino, Xia Gao, Sandeep Artham, Debarati Mukherjee, Luigi Racioppi, Patrick K. Juras
Supplementary Figures and Tables: 5 figures, 3 tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543d78854400f78d789057935c73572f
https://doi.org/10.1158/2326-6066.22545867
https://doi.org/10.1158/2326-6066.22545867
Autor:
Donald P. McDonnell, Ching-Yi Chang, Laura Akullian D'Agostino, Xia Gao, Sandeep Artham, Debarati Mukherjee, Luigi Racioppi, Patrick K. Juras
Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a key regulator of energy homeostasis in several cell types. Expression of this enzyme in tumor cells promotes proliferation and migration, and expression in tumor-associated immune cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f3261e47cdca8c8e3f7289bb932fe6
https://doi.org/10.1158/2326-6066.c.6551040
https://doi.org/10.1158/2326-6066.c.6551040
Autor:
Patrick K. Juras, Luigi Racioppi, Debarati Mukherjee, Sandeep Artham, Xia Gao, Laura Akullian D'Agostino, Ching-Yi Chang, Donald P. McDonnell
Publikováno v:
Cancer Immunol Res
Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a key regulator of energy homeostasis in several cell types. Expression of this enzyme in tumor cells promotes proliferation and migration, and expression in tumor-associated immune cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b4da0eb175335efd888c5c30843b64
https://doi.org/10.1101/2022.05.18.492328
https://doi.org/10.1101/2022.05.18.492328
Publikováno v:
Stem Cell Rev Rep
Little is known about a regulatory role of CaMKK2 for hematopoietic stem (HSC) and progenitor (HPC) cell function. To assess this, we used Camkk2−/− and wild type (WT) control mouse bone marrow (BM) cells. BM cells were collected/processed and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76de27ec16cd35c9e3de93105a1dba92
https://pubmed.ncbi.nlm.nih.gov/35262902
https://pubmed.ncbi.nlm.nih.gov/35262902
Autor:
Luigi Racioppi, John Sampson, William H. Tomaszewski, Jessica Waibl-Polania, Gunn Michael, Luis Sanchez-Perez
Publikováno v:
Neuro Oncol
BACKGROUND Immunotherapy has demonstrated efficacy in several cancers but has shown only modest effects in Glioblastoma (GBM). This is linked to the anti-inflammatory nature of the tumor microenvironment (TME) and the pro-tumor functions of brain nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c998b2b659b60a35b0513e3522508e
https://europepmc.org/articles/PMC8598747/
https://europepmc.org/articles/PMC8598747/