Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

Autor: Angela Mathison, Usman Yaqoob, Juan Pablo Arab, Vikas K. Verma, Vijay H. Shah, Philippe Mathurin, Gwen Lomberk, Sheng Cao, Rosa Martin-Mateos, Robert C. Huebert, Raul Urrutia, Thomas Greuter, Thiago M. De Assuncao, Nidhi Jalan-Sakrikar

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 197-209 (2019)

Background & Aims Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05485b74c8dd1867da61269d6422e92
https://doi.org/10.1016/j.jcmgh.2018.09.005