Examination of the skin barrier repair/wound healing process using a living skin equivalent model and matrix‐assisted laser desorption‐ionization‐mass spectrometry imaging.

Autor: Lewis, E. E. L.^1,2, Barrett, M. R. T.¹, Freeman‐Parry, L.², Bojar, R. A.¹, Clench, M. R.² m.r.clench@shu.ac.uk

Publikováno v: International Journal of Cosmetic Science. Apr2018, Vol. 40 Issue 2, p148-156. 9p.

Label-free Quantitative Proteomics and Substrate Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in ex Vivo Human Skin and a Human Living Skin Equivalent Model

Autor: James Sidaway, Cristina Russo, Jill Barber, Zubida M. Al-Majdoub, Jillian Newton, Narciso Couto, Amin Rostami-Hodjegan, Brahim Achour, Esther Karunakaran, Malcolm R. Clench

Publikováno v: Couto, N, Newton, J R A, Russo, C, Karunakaran, E, Achour, B, Al-Majdoub, Z, Sidaway, J, Rostami-Hodjegan, A, Clench, M R & Barber, J 2021, ' Label-free Quantitative Proteomics and Substrate Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in ex Vivo Human Skin and a Human Living Skin Equivalent Model ', Drug Metabolism and Disposition, vol. 49, no. 1, pp. 39-52 . https://doi.org/10.1124/dmd.120.000168

We report for the first time label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in six human skin explants and a 3D living skin equivalent model from LabSkin. We aimed to evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9adda6cb744a3a5d691ff285110f82a
https://pure.manchester.ac.uk/ws/files/178600178/Couto_etal_2020_dmd.120.000168.full.pdf

Quantitative investigation of terbinafine hydrochloride absorption into a living skin equivalent model by MALDI-MSI

Autor: Cristina Russo, Neil Brickelbank, Catherine J. Duckett, Steve Mellor, Malcolm R. Clench, Stephen Rumbelow

The combination of microspotting of analytical and internal standards, matrix sublimation, and recently developed software for quantitative mass spectrometry imaging has been used to develop a high-resolution method for the determination of terbinafi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08adf628bcc72a912ed3398321825abb
https://shura.shu.ac.uk/22212/1/Clench-QuantitativeInvestigationOfTerbinafine(AM).pdf

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Differential innate immune responses of a living skin equivalent model colonized by Staphylococcus epidermidis or Staphylococcus aureus

Autor: Mark D. Farrar, Keith T. Holland, R.A. Bojar, Diana B. Holland

Publikováno v: FEMS Microbiology Letters. 290:149-155

Staphylococcus epidermidis is a commensal on skin, whereas Staphylococcus aureus is a transient pathogen. The aim was to determine whether the skin's innate defence systems responded differently to these microorganisms. Differential gene expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1ab7a0d67ea46ad6b7a074e13e0d9d2
https://doi.org/10.1111/j.1574-6968.2008.01402.x