Zobrazeno 1 - 10
of 2 512
pro vyhledávání: '"liver toxicity."'
Autor:
Domenico Gadaleta, Marina Garcia de Lomana, Eva Serrano-Candelas, Rita Ortega-Vallbona, Rafael Gozalbes, Alessandra Roncaglioni, Emilio Benfenati
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract The adverse outcome pathway (AOP) concept has gained attention as a way to explore the mechanism of chemical toxicity. In this study, quantitative structure–activity relationship (QSAR) models were developed to predict compound activity to
Externí odkaz:
https://doaj.org/article/f64a73920b77456f89cbc33ac1b0126b
Autor:
Flaviu Muresan, Olga Hilda Orasan, Angela Cozma, Madalina Daiana Bancos, Lorena Ciumarnean, Mircea Vasile Milaciu, Tinca Codruta Pocol, Nicoleta Valentina Leach, Teodora Gabriela Alexescu, Ovidiu Vasile Fabian, George Ciulei, Mirela Georgiana Perne
Publikováno v:
Journal of Mind and Medical Sciences, Vol 11, Iss 2, Pp 337-344 (2024)
Immune checkpoint inhibitors (ICIs) are an effective immunotherapeutic approach for cancers affecting the lung, skin, kidney, mammary gland, or certain hematologic malignancies. Regarding the prognosis of these oncological conditions, treatments with
Externí odkaz:
https://doaj.org/article/fa7293bd14384acfad4fff1208595747
Publikováno v:
Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Background Following the announcement by the European Food Safety Authority that the food additive titanium dioxide (E 171) is unsafe for human consumption, and the subsequent ban by the European Commission, concerns have intensified over th
Externí odkaz:
https://doaj.org/article/81329e520bf546269a53ef18a56c5ca2
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 8, Pp 331-340 (2024)
Objective: To investigate the hepatoprotective effects of Levisticum officinale extract on CCl4-induced hepatotoxicity. Methods: Different doses of Levisticum officinale extract were given orally to rats for 10 days, then rats received a single dose
Externí odkaz:
https://doaj.org/article/d6848f17655a4cc6a19ec0b0ac94c57a
Publikováno v:
مجله علوم پزشکی فیض (پیوسته), Vol 28, Iss 4, Pp 375-382 (2024)
Background and Aim: Diclofenac, a non-steroidal anti-inflammatory drug, is known to induce liver damage. This study evaluated the protective effects of chlorogenic acid, a plant compound with anti-inflammatory and antioxidant properties, against dicl
Externí odkaz:
https://doaj.org/article/46aed02549844b0295b9fbfc2ca8314f
Publikováno v:
Journal of Medical Case Reports, Vol 18, Iss 1, Pp 1-10 (2024)
Abstract Background Although the correlation between liver toxicity and vancomycin is generally considered low, it has been observed that the use of vancomycin can lead to abnormal liver function indicators, such as elevated aspartate aminotransferas
Externí odkaz:
https://doaj.org/article/da599c68685e4ef4a6046095e344fc6c
Autor:
Hernan A. Bazan, Surjyadipta Bhattacharjee, Madigan M. Reid, Bokkyoo Jun, Connor Polk, Madeleine Strain, Linsey A. St Pierre, Neehar Desai, Patrick W. Daly, Jessica A. Cucinello-Ragland, Scott Edwards, Javier Recio, Julio Alvarez-Builla, James J. Cai, Nicolas G. Bazan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-35 (2024)
Abstract Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastrointestinal damage from chronic non-steroidal anti-inflammatory dru
Externí odkaz:
https://doaj.org/article/e955fc7d7b3b4d97b98770099763f826
Autor:
Milos Mihajlovic, Mathieu Vinken
Publikováno v:
Data in Brief, Vol 55, Iss , Pp 110653- (2024)
The provided dataset describes the transcriptomic profile of human liver spheroid co-cultures consisting of a human hepatoma cell line (C3A/HepG2 cells) and an immortalized activated human hepatic stellate cell line (LX-2 cells) upon exposure to tota
Externí odkaz:
https://doaj.org/article/b3ba336efe4d4a38ac39f785f629d356
Publikováno v:
Journal of Pharmacy, Vol 4, Iss 2 (2024)
ABSTRACT With its rising incidence, non-alcoholic fatty liver disease (NAFLD) has become a global health problem. Hepatic lipid buildup, inflammation, and oxidative stress are the results of complex interactions between metabolic, genetic, and env
Externí odkaz:
https://doaj.org/article/762a9c083e9445c4a4b192dc1a852a22
Autor:
Kim BJ, Bak SB, Bae SJ, Jin HJ, Park SM, Kim YR, Jung DH, Song CH, Kim YW, Kim SC, Lee WY, Park SD
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 549-566 (2024)
Bong-Jo Kim,1 Seon-Been Bak,1 Su-Jin Bae,1,2 Hyo-Jung Jin,3 Sang Mi Park,3 Ye-Rim Kim,3 Dae-Hwa Jung,3 Chang-Hyun Song,3 Young-Woo Kim,1 Sang-Chan Kim,3 Won-Yung Lee,2,4 Sun-Dong Park1 1Department of Korean Medicine, Dongguk University, Gyeongju, 380
Externí odkaz:
https://doaj.org/article/b17c3c8e647c455588a73158f7f287b1