Zobrazeno 1 - 10
of 1 220
pro vyhledávání: '"liver receptor homolog-1"'
Autor:
Asma Ahmed, Cindy Reinhold, Eileen Breunig, Truong San Phan, Lea Dietrich, Feodora Kostadinova, Corinne Urwyler, Verena M. Merk, Mario Noti, Israel Toja da Silva, Konstantin Bode, Fatima Nahle, Anna Pia Plazzo, Julia Koerner, Regula Stuber, Constantin Menche, Eva Karamitopoulou, Henner F. Farin, Kenneth J. Gollob, Thomas Brunner
Publikováno v:
Molecular Oncology, Vol 17, Iss 8, Pp 1545-1566 (2023)
Control of tumour development and growth by the immune system critically defines patient fate and survival. What regulates the escape of colorectal tumours from destruction by the immune system remains currently unclear. Here, we investigated the rol
Externí odkaz:
https://doaj.org/article/e2887ae1833f4172bd9bbea51ee70193
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Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Glucocorticoids (GCs) are steroid hormones predominantly produced in the adrenal glands in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory and immunosuppressive functions. Accumulating evidence in the past two
Externí odkaz:
https://doaj.org/article/6ee3162e88c243e7a88f400edc088542
Autor:
Ahmed, Asma, Reinhold, Cindy, Breunig, Eileen, Phan, Truong San, Dietrich, Lea, Kostadinova, Feodora, Urwyler, Corinne, Merk, Verena M, Noti, Mario, Toja da Silva, Israel, Bode, Konstantin, Nahle, Fatima, Plazzo, Anna Pia, Koerner, Julia, Stuber, Regula, Menche, Constantin, Karamitopoulou, Evanthia, Farin, Henner F, Gollob, Kenneth J, Brunner, Thomas
Publikováno v:
Molecular Oncology
Ahmed, Asma; Reinhold, Cindy; Breunig, Eileen; Phan, Truong San; Dietrich, Lea; Kostadinova, Feodora; Urwyler, Corinne; Merk, Verena M; Noti, Mario; Toja da Silva, Israel; Bode, Konstantin; Nahle, Fatima; Plazzo, Anna Pia; Koerner, Julia; Stuber, Regula; Menche, Constantin; Karamitopoulou, Evanthia; Farin, Henner F; Gollob, Kenneth J and Brunner, Thomas (2023). Immune escape of colorectal tumors via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids. (In Press). Molecular oncology FEBS Press 10.1002/1878-0261.13414
Ahmed, Asma; Reinhold, Cindy; Breunig, Eileen; Phan, Truong San; Dietrich, Lea; Kostadinova, Feodora; Urwyler, Corinne; Merk, Verena M; Noti, Mario; Toja da Silva, Israel; Bode, Konstantin; Nahle, Fatima; Plazzo, Anna Pia; Koerner, Julia; Stuber, Regula; Menche, Constantin; Karamitopoulou, Evanthia; Farin, Henner F; Gollob, Kenneth J and Brunner, Thomas (2023). Immune escape of colorectal tumors via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids. (In Press). Molecular oncology FEBS Press 10.1002/1878-0261.13414
Control of tumour development and growth by the immune system critically defines patient fate and survival. What regulates the escape of colorectal tumours from destruction by the immune system remains currently unclear. Here, we investigated the rol
Autor:
Hwa Young Ahn, Hwan Hee Kim, Ye An Kim, Min Kim, Jung Hun Ohn, Sung Soo Chung, Yoon-Kwang Lee, Do Joon Park, Kyong Soo Park, David D. Moore, Young Joo Park
Publikováno v:
Endocrinology and Metabolism, Vol 30, Iss 4, Pp 584-592 (2015)
BackgroundExpression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP). In this study, we aimed to find whether thyroid hormone regulates SHP expression by modulating th
Externí odkaz:
https://doaj.org/article/564287f1004a45b79b00ad5a1bd5f7d2
Akademický článek
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Publikováno v:
Molecular Biology Reports. 48:8155-8170
Nuclear receptors are the regulatory molecules that mediate cellular signals as they interact with specific DNA sequences. NR5A2 is a member of NR5A subfamily having four members (Nr5a1-Nr5a4). NR5A2 shows involvement in diverse biological processes
Perilipin 5 is a novel target of nuclear receptor LRH-1 to regulate hepatic triglycerides metabolism
Autor:
Seung Soon Im, Minsang Shin, Jae-Ho Lee, Eun Hee Koh, Rubee Pantha, Dae-Kyu Song, Jae-Hoon Bae
Publikováno v:
BMB Reports
Liver receptor homolog-1 (LRH-1) has emerged as a regulator of hepatic glucose, bile acid, and mitochondrial metabolism. However, the functional mechanism underlying the effect of LRH-1 on lipid mobilization has not been addressed. This study investi