Zobrazeno 1 - 10
of 1 218
pro vyhledávání: '"liver receptor homolog-1"'
Autor:
Asma Ahmed, Cindy Reinhold, Eileen Breunig, Truong San Phan, Lea Dietrich, Feodora Kostadinova, Corinne Urwyler, Verena M. Merk, Mario Noti, Israel Toja da Silva, Konstantin Bode, Fatima Nahle, Anna Pia Plazzo, Julia Koerner, Regula Stuber, Constantin Menche, Eva Karamitopoulou, Henner F. Farin, Kenneth J. Gollob, Thomas Brunner
Publikováno v:
Molecular Oncology, Vol 17, Iss 8, Pp 1545-1566 (2023)
Control of tumour development and growth by the immune system critically defines patient fate and survival. What regulates the escape of colorectal tumours from destruction by the immune system remains currently unclear. Here, we investigated the rol
Externí odkaz:
https://doaj.org/article/e2887ae1833f4172bd9bbea51ee70193
Akademický článek
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Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Glucocorticoids (GCs) are steroid hormones predominantly produced in the adrenal glands in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory and immunosuppressive functions. Accumulating evidence in the past two
Externí odkaz:
https://doaj.org/article/6ee3162e88c243e7a88f400edc088542
Autor:
Hwa Young Ahn, Hwan Hee Kim, Ye An Kim, Min Kim, Jung Hun Ohn, Sung Soo Chung, Yoon-Kwang Lee, Do Joon Park, Kyong Soo Park, David D. Moore, Young Joo Park
Publikováno v:
Endocrinology and Metabolism, Vol 30, Iss 4, Pp 584-592 (2015)
BackgroundExpression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP). In this study, we aimed to find whether thyroid hormone regulates SHP expression by modulating th
Externí odkaz:
https://doaj.org/article/564287f1004a45b79b00ad5a1bd5f7d2
Publikováno v:
Molecular Biology Reports. 48:8155-8170
Nuclear receptors are the regulatory molecules that mediate cellular signals as they interact with specific DNA sequences. NR5A2 is a member of NR5A subfamily having four members (Nr5a1-Nr5a4). NR5A2 shows involvement in diverse biological processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f6dba18f234f0239ee701fb1201a48
https://doi.org/10.1007/s11033-021-06784-1
https://doi.org/10.1007/s11033-021-06784-1
Perilipin 5 is a novel target of nuclear receptor LRH-1 to regulate hepatic triglycerides metabolism
Autor:
Seung Soon Im, Minsang Shin, Jae-Ho Lee, Eun Hee Koh, Rubee Pantha, Dae-Kyu Song, Jae-Hoon Bae
Publikováno v:
BMB Reports
Liver receptor homolog-1 (LRH-1) has emerged as a regulator of hepatic glucose, bile acid, and mitochondrial metabolism. However, the functional mechanism underlying the effect of LRH-1 on lipid mobilization has not been addressed. This study investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064d13b7ac71d60223132104a31a146c
http://europepmc.org/articles/PMC8505233
http://europepmc.org/articles/PMC8505233
Autor:
David J. Orlicky, Karim C. El Kasmi, Mark A. Lovell, Swati Ghosh, Ronald J. Sokol, Aimee L. Anderson, Sarah Gehrke, Michael W. Devereaux, Julie A. Reisz, Colin T. Shearn, Angelo D'Alessandro
Publikováno v:
Hepatology
BACKGROUND AND AIMS: Chronically administered parenteral nutrition (PN) in patients with intestinal failure carries the risk for developing PN-associated cholestasis (PNAC). We have demonstrated that farnesoid X receptor (FXR) and liver X receptor (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f891a063835002c199614ef64d3d2e
https://doi.org/10.1002/hep.32071
https://doi.org/10.1002/hep.32071
Autor:
Zac Beine, Erik Eastwood, Matthew T. Simpson, Derek Gross, Zimei Wang, Murray Blackmore, Michael Cabahug, Advaita Chakraborty, Greta Olson, Ishwariya Venkatesh, Vatsal Mehra
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Transcription factors (TFs) act as powerful levers to regulate neural physiology and can be targeted to improve cellular responses to injury or disease. Because TFs often depend on cooperative activity, a major challenge is to identify and deploy opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3451dfe2db817afdc272de78c1a44648
https://doaj.org/article/fd22a732183e4c72a9a568ef622f169e
https://doaj.org/article/fd22a732183e4c72a9a568ef622f169e