Zobrazeno 1 - 10
of 199
pro vyhledávání: '"liver organoid"'
Autor:
Feng Zhiwei, Zhou Bingrui, Shuai Qizhi, Wei Yunliang, Jin Ning, Wang Xiaoling, Zhao Hong, Liu Zhizhen, Xu Jun, Mu Jianbing, Xie Jun
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1460-1472 (2024)
Alcoholic liver disease (ALD) poses a significant health challenge, so comprehensive research efforts to improve our understanding and treatment strategies are needed. However, the development of effective treatments is hindered by the limitation of
Externí odkaz:
https://doaj.org/article/9d2a9031fe39414a80e6a9a7a5efa395
Autor:
Jiaqi Zhou, Yi‐chun Huang, Wanlong Wang, Jiawei Li, Yibo Hou, Ziqi Yi, Haowei Yang, Keer Hu, Yu Zhu, Zitian Wang, Shaohua Ma
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract The circadian clock coordinates the daily rhythmicity of biological processes, and its dysregulation is associated with various human diseases. Despite the direct targeting of rhythmic genes by many prevalent and World Health Organization (W
Externí odkaz:
https://doaj.org/article/0107b3b305574f9ca2a5a9e5028a1f35
Autor:
Yiqing Hu, Xiaoyi Hu, Jia Luo, Jiacheng Huang, Yaohan Sun, Haoyu Li, Yinbiao Qiao, Hao Wu, Jianhui Li, Lin Zhou, Shusen Zheng
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract Organoids, three-dimensional structures cultured in vitro, can recapitulate the microenvironment, complex architecture, and cellular functions of in vivo organs or tissues. In recent decades, liver organoids have been developed rapidly, and
Externí odkaz:
https://doaj.org/article/c8ad3266f1394f58abec706828871a9c
Autor:
Negar Aasadollahei, Niloufar Rezaei, Reihaneh Golroo, Tarun Agarwal, Massoud Vosough, Abbas Piryaei
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 367-391 (2023)
Non-alcoholic fatty liver disease (NAFLD) has become the world’s most common chronic liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development studies have faced many limitations, and there is no food and drug admi
Externí odkaz:
https://doaj.org/article/4dc0b365249e4640988d73e32bc9c1e1
Publikováno v:
Cell Regeneration, Vol 12, Iss 1, Pp 1-13 (2023)
Abstract Preclinical models that can accurately predict the toxicity and efficacy of candidate drugs to human liver tissue are in urgent need. Human liver organoid (HLO) derived from human pluripotent stem cells offers a possible solution. Herein, we
Externí odkaz:
https://doaj.org/article/e40e5aca2eeb4d9ab8544b0770ee70e0
Autor:
Seo Yoon Choi, Tae Hee Kim, Min Jeong Kim, Seon Ju Mun, Tae Sung Kim, Ki Kyung Jung, Il Ung Oh, Jae Ho Oh, Myung Jin Son, Jin Hee Lee
Publikováno v:
Toxics, Vol 12, Iss 5, p 371 (2024)
“Organoids”, three-dimensional self-organized organ-like miniature tissues, are proposed as intermediary models that bridge the gap between animal and human studies in drug development. Despite recent advancements in organoid model development, s
Externí odkaz:
https://doaj.org/article/0b786a53de2f47699299e05026f37a13
Autor:
Hyo Jin Kim, Gyeongmin Kim, Kyun Yoo Chi, Hyemin Kim, Yu Jin Jang, Seongyea Jo, Jihun Lee, Youngseok Lee, Dong-Hun Woo, Choongseong Han, Sang Kyum Kim, Han-Jin Park, Jong-Hoon Kim
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background The generation of liver organoids recapitulating parenchymal and non-parenchymal cell interplay is essential for the precise in vitro modeling of liver diseases. Although different types of multilineage liver organoids (mLOs) have
Externí odkaz:
https://doaj.org/article/33f9d3996cf44d998c0860823c16d166
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Primary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of hepatocellular carcinoma (HCC) ca
Externí odkaz:
https://doaj.org/article/f80212a8c3134ff19de325c697ecafad
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Akademický článek
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