Zobrazeno 1 - 10
of 4 197
pro vyhledávání: '"liquid−liquid phase separation"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cellular senescence occurs through the accumulation of many kinds of stresses. Senescent cells in tissues also cause various age-related disorders. Therefore, detecting them without labeling is beneficial for medical research and developing
Externí odkaz:
https://doaj.org/article/c95a64e0d98848b6981f68cf432a4507
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Bladder carcinoma (BLCA) represents a common urinary tract malignancy, characterized by aggressive behavior and high recurrence rates. The biological response regulation during tumor proliferation and metastasis is intimately associated with
Externí odkaz:
https://doaj.org/article/40bae8d5ac47404c82c83101c09f516a
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Biomolecular condensates formed by liquid-liquid phase separation (LLPS) have become an extensive mechanism of macromolecular metabolism and biochemical reactions in cells. Large molecules like proteins and nucleic acids will spontaneously a
Externí odkaz:
https://doaj.org/article/977fe3c9f115401580f702218fa973a7
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract ATG9A is the only integral membrane protein among core autophagy-related (ATG) proteins. We previously found that ATG9A does not co-assemble into synaptophysin-positive vesicles, but rather, localizes to a distinct pool of vesicles within sy
Externí odkaz:
https://doaj.org/article/51c92ab5e93849098176c7bb59f90ac6
Autor:
Tommaso Staderini, Alessandra Bigi, Clément Lagrève, Isabella Marzi, Francesco Bemporad, Fabrizio Chiti
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-23 (2024)
Abstract Background Frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-TDP), amyotrophic lateral sclerosis (ALS) and limbic-predominant age-related TDP-43 encephalopathy (LATE) are associated with deposition of cytoplasmic inc
Externí odkaz:
https://doaj.org/article/e1eb3d9228d14497a55b7d9cb521a9a2
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
ABSTRACTDNA double-strand break (DSB) is the most dangerous type of DNA damage, which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two typical DSB repair mechanisms. Recently, m
Externí odkaz:
https://doaj.org/article/7751d5556522435ca788274cdf66af7c
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundBreast cancer, characterized by its heterogeneity, is a leading cause of mortality among women. The study aims to develop a Machine Learning-Derived Liquid-Liquid Phase Separation (MDLS) model to enhance the prognostic accuracy and personal
Externí odkaz:
https://doaj.org/article/fcd79798ae8c4ba89c64cedc1d8b7db4
Publikováno v:
Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)
Abstract Proteins with intrinsically disordered regions (IDRs) often undergo phase separation to control their functions spatiotemporally. Changing the pH alters the protonation levels of charged sidechains, which in turn affects the attractive or re
Externí odkaz:
https://doaj.org/article/4a14fefd0ad24ba6b684a449db70ba2c
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Parkinson’s disease (PD) and other synucleinopathies are characterized by the aggregation and deposition of alpha-synuclein (α-syn) in brain cells, forming insoluble inclusions such as Lewy bodies (LBs) and Lewy neurites (LNs). The aggregation of
Externí odkaz:
https://doaj.org/article/7f8789cf8e944d3cb3893e93a58ccfd1
Autor:
Xuesong Li, Zhuo Yu
Publikováno v:
Cancer Innovation, Vol 3, Iss 5, Pp n/a-n/a (2024)
Abstract Liquid–liquid phase separation (LLPS) has emerged as a pivotal biological phenomenon involved in various cellular processes, including the formation of membrane‐less organelles and the regulation of biomolecular condensates through preci
Externí odkaz:
https://doaj.org/article/b1bdae6dbdba482ab6f6500fbc05e6ea