Zobrazeno 1 - 10
of 1 392
pro vyhledávání: '"lipophagy"'
Publikováno v:
陆军军医大学学报, Vol 46, Iss 20, Pp 2301-2312 (2024)
Objective To investigate the effect and mechanism of quercetin (QUE) in improving lipid accumulation in hepatocytes by regulating lipolysis and lipophagy pathway. Methods The human hepatocyte cell line 5 (HHL-5) was induced by palmitic acid (PA) to e
Externí odkaz:
https://doaj.org/article/cd1547d0623f489fa3e8be850bab6667
Autor:
Yibao Fan, Wei Zhang, Zoya Iqbal, Xinxin Li, Zhiyin Lin, Zhuolin Wu, Qianyou Li, Hongxia Dong, Xianbin Zhang, Peng Gong, Peng Liu
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Bufalin (BA) is a potent traditional Chinese medicine derived from toad venom. It has shown significant antitumor activity, but its use is limited by cardiotoxicity, which necessitates innovative delivery methods, such as rod-shap
Externí odkaz:
https://doaj.org/article/294653d0165b4c6998a58dd940aefd0a
Autor:
Yuan-Mei Wang, Huang Tang, Ya-Jie Tang, Juan Liu, Yu-Fang Yin, Ya-Ling Tang, Yao-Guang Feng, Hong-Feng Gu
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 195-206 (2024)
Introduction: Atherosclerosis, a major contributor to cardiovascular disease, remains a significant health concern worldwide. While previous research has shown that acid-sensing ion channel 1 (ASIC1) impedes macrophage cholesterol efflux, its precise
Externí odkaz:
https://doaj.org/article/2766660ceca342afa880008de586d130
Publikováno v:
Clinical and Molecular Hepatology, Vol 30, Iss 3, Pp 515-538 (2024)
Background/Aims Metabolic dysfunction-associated steatohepatitis (MASH) is an unmet clinical challenge due to the rapid increased occurrence but lacking approved drugs. Autophagy-related protein 16-like 1 (ATG16L1) plays an important role in the proc
Externí odkaz:
https://doaj.org/article/88c60ffc38bf4f47a005c9ca193c30dc
Autor:
Hao Ma, Zhi-lin Ou, Nima Alaeiilkhchi, Yong-quan Cheng, Kai Chen, Jia-yu Chen, Ru-qin Guo, Min-yue He, Shi-yi Tang, Xin Zhang, Zhi-ping Huang, Junhao Liu, Jie Liu, Qing-an Zhu, Zu-cheng Huang, Hui Jiang
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background Lipid droplet (LD)-laden microglia is a key pathological hallmark of multiple sclerosis. The recent discovery of this novel microglial subtype, lipid-droplet-accumulating microglia (LDAM), is notable for increased inflammatory fac
Externí odkaz:
https://doaj.org/article/e2579bfb244b468399d0db9181da1dad
Autor:
Jiahan Ke, Jianan Pan, Hao Lin, Shuying Huang, Junfeng Zhang, Changqian Wang, Alex Chia Yu Chang, Jun Gu
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract Diabetic cardiomyopathy (DbCM) is characterized by diastolic dysfunction, which progresses into heart failure and aberrant electrophysiology in diabetic patients. Dyslipidemia in type 2 diabetic patients leads to the accumulation of lipid dr
Externí odkaz:
https://doaj.org/article/6b01fe2e18ef4f3da0d98b810a2910c6
Autor:
Yihui Wang, Yuan Song, Lingling Xu, Wuqi Zhou, Wenyuan Wang, Qiaofeng Jin, Yuji Xie, Junmin Zhang, Jing Liu, Wenqian Wu, He Li, Le Liang, Jing Wang, Yali Yang, Xiongwen Chen, Shuping Ge, Tang Gao, Li Zhang, Mingxing Xie
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Myocardial ischemia/reperfusion injury (MIRI) is the leading cause of irreversible myocardial damage. A pivotal pathogenic factor is ischemia/reperfusion (I/R)‐induced cardiomyocyte ferroptosis, marked by iron overload and lipid peroxidati
Externí odkaz:
https://doaj.org/article/19e5d6c83314418db38d091e475bdab4
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Ovarian clear cell carcinoma (OCCC) is a histological subtype that constitutes approximately 20% of epithelial ovarian cancer cases in Asian countries, but has a relatively low incidence in Western countries. Meanwhile, clear cell renal cell carcinom
Externí odkaz:
https://doaj.org/article/b473f0520a4d472e860a87596ab8d9ae
Autor:
Elisa Balboa, Faride Saud, Claudia Parra-Ruiz, Marjorie de la Fuente, Glauben Landskron, Silvana Zanlungo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The global prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is increasing, now affecting 25%–30% of the population worldwide. MASLD, characterized by hepatic steatosis, results from an imbalance in lipid metabolism, le
Externí odkaz:
https://doaj.org/article/75f033f67ad1442a8df751d7a3b3e3f6
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 277, Iss , Pp 116394- (2024)
Mono-2-ethylhexyl phthalic acid (MEHP) is the most toxic metabolite of the plasticizer di-2-ethylhexyl phthalic acid (DEHP), and studies have shown that MEHP causes serious reproductive effects. However, its exact mechanisms of action remain elusive.
Externí odkaz:
https://doaj.org/article/47d84a80a8064225be4032210680725e