Zobrazeno 1 - 10
of 191
pro vyhledávání: '"lipid kinases"'
Autor:
Gabriela Ulloa, Fadi Hamati, Alexander Dick, Julie Fitzgerald, Judith Mantell, Paul Verkade, Lucy Collinson, Kenton Arkill, Banafshe Larijani, Dominic Poccia
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1880-1891 (2019)
The ER is a large multifunctional organelle of eukaryotic cells. Malfunction of the ER in various disease states, such as atherosclerosis, diabetes, cancer, Alzheimer's and Parkinson's and amyotrophic lateral sclerosis, often correlates with alterati
Externí odkaz:
https://doaj.org/article/e6e92bb021c443008ffcc43bf2a154ee
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 747-752 (2019)
The discovery of the phosphatidylinositol-3-kinase (PI3K) pathway was a major advance in understanding growth factor signaling. The high frequency of PI3K pathway mutations in many cancers has encouraged a new field targeting cancer driver mutations.
Externí odkaz:
https://doaj.org/article/9a98f0f982c443b8adc74442f31f18ed
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1316-1324 (2018)
Intercellular communication has been known for decades to involve either direct contact between cells or to operate via circulating molecules, such as cytokines, growth factors, or lipid mediators. During the last decade, we have begun to appreciate
Externí odkaz:
https://doaj.org/article/a0a9cb8964704ae6a6b38b8450eeef9e
Autor:
Boubacar Benziane, Melissa L. Borg, Robby Z. Tom, Isabelle Riedl, Julie Massart, Marie Björnholm, Marc Gilbert, Alexander V. Chibalin, Juleen R. Zierath
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 12, Pp 2324-2333 (2017)
Diacylglycerol kinases (DGKs) regulate the balance between diacylglycerol (DAG) and phosphatidic acid. DGKζ is highly abundant in skeletal muscle and induces fiber hypertrophy. We hypothesized that DGKζ influences functional and metabolic adaptatio
Externí odkaz:
https://doaj.org/article/a575ec213d4c468c8904d8f011c9405b
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2016 Aug 01. 113(31), 8711-8716.
Externí odkaz:
https://www.jstor.org/stable/26471029
Autor:
Ke Liu, Naoko Kunii, Megumi Sakuma, Atsumi Yamaki, Satoru Mizuno, Mayu Sato, Hiromichi Sakai, Sayaka Kado, Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yasuhito Shirai, Fumio Sakane
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 3, Pp 368-379 (2016)
Diacylglycerol kinase (DGK) consists of 10 isozymes. The α-isozyme enhances the proliferation of cancer cells. However, DGKα facilitates the nonresponsive state of immunity known as T-cell anergy; therefore, DGKα enhances malignant traits and supp
Externí odkaz:
https://doaj.org/article/dc143d608bfc4fb194ef0301e1ccb9c8
Autor:
Simon A. Rudge, Michael J.O. Wakelam
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 2, Pp 176-192 (2016)
Signaling through the phosphoinositide 3-kinase pathways mediates the actions of a plethora of hormones, growth factors, cytokines, and neurotransmitters upon their target cells following receptor occupation. Overactivation of these pathways has been
Externí odkaz:
https://doaj.org/article/db40a123999845ddbc46189c896576b6
Autor:
Tuoyu Geng, Alton Sutter, Michael D. Harland, Brittany A. Law, Jessica S. Ross, David Lewin, Arun Palanisamy, Sarah B. Russo, Kenneth D. Chavin, L.Ashley Cowart
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2359-2371 (2015)
Steatohepatitis occurs in up to 20% of patients with fatty liver disease and leads to its primary disease outcomes, including fibrosis, cirrhosis, and increased risk of hepatocellular carcinoma. Mechanisms that mediate this inflammation are of major
Externí odkaz:
https://doaj.org/article/4519660e72ac41d8ad4845ac4516f82f
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 1, Pp 149-157 (2012)
Choline kinase catalyzes the phosphorylation of choline, the first step of phospholipid synthesis. Increased phosphorylation of choline is a hallmark characteristic of the malignant phenotype in a variety of neoplasms. However, in hypoxic cancer cell
Externí odkaz:
https://doaj.org/article/d267338d5322424293657f4bf9647136
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3091-3102 (2010)
Despite the ubiquitous roles of lipids in biology, the detection of lipids has relied on invasive techniques, population measurements, or nonspecific labeling. Such difficulties can be circumvented by a label-free imaging technique known as coherent
Externí odkaz:
https://doaj.org/article/da929da2ef214542b21ad6e2a7532160