Advances in chemical proteomic evaluation of lipid kinases – DAG kinases as a case study

Autor: Timothy B. Ware, Ku-Lung Hsu

Publikováno v: Curr Opin Chem Biol

Advancements in chemical proteomics and mass spectrometry lipidomics are providing new opportunities to understand lipid kinase activity, specificity, and regulation on a global cellular scale. Here, we describe recent developments in chemical biolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede7511d047303f99e6a58e227ad28c3
https://europepmc.org/articles/PMC8671151/

HDX-MS optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

Autor: Calvin K. Yip, Noah J Harris, Manoj K. Rathinaswamy, Jan Steyaert, Udit Dalwadi, Kaelin D. Fleming, Els Pardon, John E. Burke

There is considerable interest in developing antibodies as modulators of signaling pathways. One of the most important signaling pathways in higher eukaryotes is the phosphoinositide 3-kinase (PI3K) pathway, which plays fundamental roles in growth, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9edf7fc5af8c39acddd0d98218a7f9b1
https://doi.org/10.1101/2021.06.01.446614

Sorting nexin 5 mediates virus-induced autophagy and immunity

Autor: Elizabeth R. Aguilera, Xuewu Zhang, Liwei Wang, Sandra L. Schmid, Nicholas T. Ktistakis, Bo Ci, Ramnik J. Xavier, John W. Schoggins, Julie K. Pfeiffer, Xiaonan Dong, Boris Simonetti, Madhura Bhave, Yuting Yang, R. Blake Richardson, Peter J. Cullen, Xiao Zang, Y. Zhao, Paul A. Gleeson, Guanghua Xiao, Li Yu, Yi Chun Kuo, Lin Zhong, Yang Xie, Zhongju Zou, Beth Levine, Rui Zhong

Publikováno v: Simonetti, B, Cullen, P J, Xavier, R & et al. 2020, ' Sorting nexin 5 mediates virus-induced autophagy and immunity ', Nature, vol. 589, pp. 456–461 . https://doi.org/10.1038/s41586-020-03056-z

Autophagy, a process of degradation that occurs via the lysosomal pathway, has an essential role in multiple aspects of immunity, including immune system development, regulation of innate and adaptive immune and inflammatory responses, selective degr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4897847f9ff4d9c8da454fc2b803db26
https://research-information.bris.ac.uk/ws/files/263285649/SIGuide.pdf

Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib

Autor: Jun Shi, Guangrong Zhu, Ling Huang, Hui Zhao, Yideng Jiang, Shaoting Zhang, Yue Guo, Jianmin Sun

Publikováno v: Cell & Bioscience
Cell & Bioscience, Vol 10, Iss 1, Pp 1-13 (2020)

Background KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation of KIT confers drug resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51335427a1d644c817448aae7b9df95e
https://doi.org/10.1186/s13578-020-0377-9

The deubiquitinase USP11 is a versatile and conserved regulator of autophagy

Autor: Justyna Bajdzienko, Andreas Kern, Mila Basic, Alexandra Hertel, Mariana Tellechea, Alexandra Stolz, Florian Bonn, Christian Behl, Anja Bremm

Publikováno v: The Journal of Biological Chemistry

Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6aec8482a221b2fc2ecdbdb5981944
https://doi.org/10.1016/j.jbc.2021.101263