Evaluation of the Potential of Novel Co-Processed Excipients to Enable Direct Compression and Modified Release of Ibuprofen

Autor: Ivana Aleksić, Teodora Glišić, Slobodanka Ćirin-Varađan, Mihal Djuris, Jelena Djuris, Jelena Parojčić

Publikováno v: Pharmaceutics, Vol 16, Iss 11, p 1473 (2024)

Background/Objectives: Improving the production rates of modern tablet presses places ever greater demands on the performance of excipients. Although co-processing has emerged as a promising solution, there is still a lack of directly compressible ex

Externí odkaz: https://doaj.org/article/febb2d699e364012a0dec572ec7ff96f

Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development

Autor: Deepa Nakmode, Valamla Bhavana, Pradip Thakor, Jitender Madan, Pankaj Kumar Singh, Shashi Bala Singh, Jessica M. Rosenholm, Kuldeep K. Bansal, Neelesh Kumar Mehra

Publikováno v: Pharmaceutics, Vol 14, Iss 4, p 831 (2022)

Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre

Externí odkaz: https://doaj.org/article/92c80f3a1b404a5288dae79584834698

Lipid Based Formulations in Hard Gelatin and HPMC Capsules: a Physical Compatibility Study

Autor: Hans Coppenolle, Ingrid Djouka Tenekam, Sanket M. Shah, Nicolas Sauwen, Niklas J. Koehl, René Holm, Sien Vingerhoets, Tatsiana Khamiakova

Publikováno v: Koehl, N J, Shah, S, Tenekam, I D, Khamiakova, T, Sauwen, N, Vingerhoets, S, Coppenolle, H & Holm, R 2021, ' Lipid Based Formulations in Hard Gelatin and HPMC Capsules : a Physical Compatibility Study ', Pharmaceutical Research, vol. 38, no. 8, pp. 1439-1454 . https://doi.org/10.1007/s11095-021-03088-8

Purpose: To investigate the compatibility between hard gelatin and HPMC capsules with a range of different isotropic lipid based formulations containing multiple excipients. Methods: The miscibility was investigated for 350 systems applying five diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300bcef8f1e425589fb7789904303b68
https://doi.org/10.1007/s11095-021-03088-8

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Toward simplified oral lipid-based drug delivery using mono-/di-glycerides as single component excipients

Autor: René Holm, Koen Wuyts, Ruzica Kolakovic, Brendan T. Griffin, Martin Kuentz, Filip Cuyckens, Alexandra Roxana Ilie, Maria Vertzoni

Publikováno v: Drug Development and Industrial Pharmacy

This study aimed to systematically explore compositional effects for a series of lipid systems, on the in vitro drug solubilization and in vivo bioavailability of three poorly water-soluble drugs with different physico-chemical properties. While many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc88a0e5b0bc15833b2590922259b7a
https://hdl.handle.net/10468/10811