Výsledky vyhledávání - "lipase/lipoprotein"

Akademický článek

Characterization of sexual dimorphism in ANGPTL4 levels and function

Publikováno v: Journal of Lipid Research, Vol 65, Iss 4, Pp 100526- (2024)

ANGPTL4 is an attractive pharmacological target for lowering plasma triglycerides and cardiovascular risk. Since most preclinical studies on ANGPTL4 were performed in male mice, little is known about sexual dimorphism in ANGPTL4 regulation and functi

Externí odkaz: https://doaj.org/article/29b54d47b782485383571c09ecfaaed9

Zobrazit plný text záznamu

Akademický článek

Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits

Autor: William G. Hoffmann, Yan Q. Chen, Charles S. Schwartz, Jacob L. Barber, Prasun K. Dev, Riley J. Reasons, Juan S. Miranda Maravi, Bridget Armstrong, Robert E. Gerszten, Günther Silbernagel, Robert J. Konrad, Claude Bouchard, Mark A. Sarzynski

Publikováno v: Journal of Lipid Research, Vol 65, Iss 2, Pp 100495- (2024)

Angiopoietin-like protein (ANGPTL) complexes 3/8 and 4/8 are established inhibitors of LPL and novel therapeutic targets for dyslipidemia. However, the effects of regular exercise on ANGPTL3/8 and ANGPTL4/8 are unknown. We characterized ANGPTL3/8 and

Externí odkaz: https://doaj.org/article/c80e12bbb63f48e2af9a00413e84aaba

Zobrazit plný text záznamu

Akademický článek

ANGPTL3 (Angiopoietin‐Like 3) Preferentially Resides on High‐Density Lipoprotein in the Human Circulation, Affecting Its Activity

Autor: Jordan M. Kraaijenhof, Tycho R. Tromp, Nick S. Nurmohamed, Laurens F. Reeskamp, Marije Langenkamp, Johannes H. M. Levels, S. Matthijs Boekholdt, Nicholas J. Wareham, Menno Hoekstra, Erik S. G. Stroes, G. Kees Hovingh, Aldo Grefhorst

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 21 (2023)

Background ANGPTL3 (angiopoietin‐like protein 3) is an acknowledged crucial regulator of lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase. It is currently unknown whether and to which lipoproteins ANG

Externí odkaz: https://doaj.org/article/bafeced5a2c34d4aab76891c406e105f

Zobrazit plný text záznamu

Akademický článek

ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

Autor: Mingjuan Deng, Elda Kutrolli, Anne Sadewasser, Sven Michel, Masoumeh Motamedi Joibari, Frank Jaschinski, Gunilla Olivecrona, Stefan K. Nilsson, Sander Kersten

Publikováno v: Journal of Lipid Research, Vol 63, Iss 7, Pp 100237- (2022)

Angiopoietin-like 4 (ANGPTL4) is an important regulator of plasma triglyceride (TG) levels and an attractive pharmacological target for lowering plasma lipids and reducing cardiovascular risk. Here, we aimed to study the efficacy and safety of silenc

Externí odkaz: https://doaj.org/article/d5cff7e2f7ae4032a5fb717f4f1072c3

Zobrazit plný text záznamu

Akademický článek

Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice

Autor: Alexander W. Fischer, Janina Behrens, Frederike Sass, Christian Schlein, Markus Heine, Paul Pertzborn, Ludger Scheja, Joerg Heeren

Publikováno v: Journal of Lipid Research, Vol 61, Iss 11, Pp 1377-1389 (2020)

Adaptive thermogenesis is highly dependent on uncoupling protein 1 (UCP1), a protein expressed by thermogenic adipocytes present in brown adipose tissue (BAT) and white adipose tissue (WAT). Thermogenic capacity of human and mouse BAT can be measured

Externí odkaz: https://doaj.org/article/1d35fad949ca4d33ae41051241cad7c3

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats

Autor: Ryota Izumi, Toru Kusakabe, Michio Noguchi, Hiroshi Iwakura, Tomohiro Tanaka, Takashi Miyazawa, Daisuke Aotani, Kiminori Hosoda, Kenji Kangawa, Kazuwa Nakao

Publikováno v: Journal of Lipid Research, Vol 59, Iss 9, Pp 1575-1585 (2018)

Angiopoietin-like protein (ANGPTL)8 is a liver- and adipocyte-derived protein that controls plasma triglyceride (TG) levels. Most animal studies have used mouse models. Here, we generated an Angptl8 KO rat model using a clustered regulatory interspac

Externí odkaz: https://doaj.org/article/b764ac46e3b5465abbc3c35599446ab0

Zobrazit plný text záznamu

Akademický článek

A new enzyme-linked immunosorbent assay system for human serum hepatic triglyceride lipase

Autor: Kazuya Miyashita, Katsuyuki Nakajima, Isamu Fukamachi, Yuji Muraba, Takafumi Koga, Yohnosuke Shimomura, Tetsuyo Machida, Masami Murakami, Junji Kobayashi

Publikováno v: Journal of Lipid Research, Vol 58, Iss 8, Pp 1591-1597 (2017)

There is no established method for measuring human hepatic triglyceride (TG) lipase (HTGL) concentration in serum. In this study, we developed new monoclonal Abs (MoAbs) (9A1 mouse MoAb and 141A1 rat MoAb) that react with HTGL both in serum and in po

Externí odkaz: https://doaj.org/article/ca7c90862a3e47d0bf2b89baf6fc1a13

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání