Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins

Autor: Yuen Lam Dora Ng, Aleša Bricelj, Jacqueline A. Jansen, Arunima Murgai, Kirsten Peter, Katherine A. Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach, Izidor Sosič

Publikováno v: Journal of medicinal chemistry, vol. 66, no. 7, pp. 4703-4733, 2023.
Journal of medicinal chemistry, str. 4703-4733 : Ilustr., Vol. 66, iss. 7, 2023
COBISS-ID: 512806681

Proteolysis targeting chimeras (PROTACs) represent a new pharmacological modality to inactivate disease-causing proteins. PROTACs operate via recruiting E3 ubiquitin ligases, which enable the transfer of ubiquitin tags onto their target proteins, lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e25f1087502a057345c9d203428b453
https://hdl.handle.net/20.500.12556/RUL-145892

Analyte-Driven Clustering of Bio-Conjugated Magnetic Nanoparticles

Autor: Tilen Potisk, Jurij Sablić, Daniel Svenšek, Elena Sanz‐de Diego, Francisco J. Teran, Matej Praprotnik

Publikováno v: Advanced theory and simulations, vol. 2200796, pp. 1-14, 2023.
Advanced theory and simulations
Advanced theory and simulations, str. 1-14 : Ilustr., Vol. 6, iss. 5, [article no.] 2200796, 3. Mar. 2023
COBISS-ID: 21312790
Advanced theory and simulations, vol. 6, no. 5, 2200796, 2023.

The dynamics of bio-conjugated magnetic nanoparticles suspended in buffer-saline solutions containing target proteins (i.e., analytes) is investigated numerically on a mesoscopic level. To simulate the dispersion of magnetic nanoparticles the dissipa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e725ca8aa679f5b79401e8434f07c6cb
http://hdl.handle.net/20.500.12614/3307

Biogeokemijsko kruženje vanadija (+IV i +V) u vodenim sustavima i sedimentima

Autor: Knežević, Lucija

The PhD thesis is based on the developed and adapted specific analytical methods for determination of vanadium redox species concentration in the water samples and bioavailable phase of surface sediment of Krka River esturay. The results show that V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3908::764498e79d98299e3d014a2202f4bb67
https://repozitorij.pmf.unizg.hr/islandora/object/pmf:11731

Razvoj peptidnih modulatorjev delovanja leptina in vrednotenje njihove biološke aktivnosti

Autor: Molek, Peter

Leptin je adipocitni hormon proteinske narave (adipokin), ki ima pomembno vlogo pri uravnavanju energijskega ravnovesja organizma. Njegova koncentracija v plazmi je odvisna od količine belega maščevja in sprememb energijskega statusa organizma. Ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3505::500a8c5d885f59227cb7b558944bc9af
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=143722

Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg2

Autor: Francesca Paoletti, Sonia Covaceuszach, Alberto Cassetta, Antonio N. Calabrese, Urban Novak, Petr Konarev, Jože Grdadolnik, Doriano Lamba, Simona Golič Grdadolnik

Publikováno v: Protein science, vol. 32, no. 2, e4563, pp. 1-14, 2023.
Protein Science
Protein science 32(2), e4563 (2023). doi:10.1002/pro.4563
Paoletti, Francesca; Covaceuszach, Sonia; Cassetta, Alberto; Calabrese, Antonio N; Novak, Urban; Konarev, Petr; Grdadolnik, Jože; Lamba, Doriano; Golič Grdadolnik, Simona (2023). Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg2. Protein science, 32(2), e4563. Wiley-Blackwell 10.1002/pro.4563

Protein science 32(2), e4563 (2023). doi:10.1002/pro.4563
Nerve growth factor (NGF), the prototypical neurotrophic factor, is involved in the maintenance and growth of specific neuronal populations, whereas its precursor, proNGF, is involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8445c96cd75f3cd076573a1ef57854c4