On-chip crystallization for serial crystallography experiments and on-chip ligand-binding studies

Autor: Julia Lieske, Maximilian Cerv, Stefan Kreida, Dana Komadina, Janine Fischer, Miriam Barthelmess, Pontus Fischer, Tim Pakendorf, Oleksandr Yefanov, Valerio Mariani, Thomas Seine, Breyan H. Ross, Eva Crosas, Olga Lorbeer, Anja Burkhardt, Thomas J. Lane, Sebastian Guenther, Julian Bergtholdt, Silvan Schoen, Susanna Törnroth-Horsefield, Henry N. Chapman, Alke Meents

Publikováno v: IUCrJ, Vol 6, Iss 4, Pp 714-728 (2019)

Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallography experiments. Compared with other methods, fixed-target sample delivery offers the advantage of significantly reduced sample consumption and shorter

Externí odkaz: https://doaj.org/article/9cf038e492ec4349b8a7aa1396ce04ee

A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography

Autor: Claude Sauter, K. Rollet, J. Roche, R. De Wijn, Vincent Olieric, Jose A. Gavira, Eric Girard, Christoph Mueller-Dieckmann, Karl Brillet, Sylvain Engilberge, O. Hennig, A. Roussel, Bernard Lorber, Mario Mörl, Heike Betat, Pablo Fernandez-Millan, G.C. Fox

Publikováno v: IUCrJ
International Union of Crystallography journal
International Union of Crystallography journal, International Union of Crystallography 2019, 6 (3), pp.454-464. ⟨10.1107/S2052252519003622⟩
'IUCrJ ', vol: 6, pages: 454-464 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digibug. Repositorio Institucional de la Universidad de Granada
IUCrJ = International Union of Crystallography journal
IUCrJ = International Union of Crystallography journal, International Union of Crystallography 2019, 6 (3), pp.454-464. ⟨10.1107/S2052252519003622⟩
International Union of Crystallography journal, 2019, 6 (3), pp.454-464. ⟨10.1107/S2052252519003622⟩
IUCrJ, Vol 6, Iss 3, Pp 454-464 (2019)

Determining optimal conditions for the production of well diffracting crystals is a key step in every biocrystallography project. Here, a microfluidic device is described that enables the production of crystals by counter-diffusion and their direct o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13d1696b1150fc407143cec2be20534
http://europepmc.org/articles/PMC6503916

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Crystal packing modifies ligand binding affinity: The case of aldose reductase

Autor: Cousido-Siah, Alexandra, Petrova, Tatiana, Hazemann, Isabelle, Mitschler, André, Ruiz, Francesc X., Howard, Eduardo Ignacio, Ginell, Stepahn, Atmanene, Cédric, Van Dorsselaer, Alain, Sanglier-Cienférani, Sarah, Joachimiak, Andrzej, Podjarny, Alberto

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The relationship between the structures of protein-ligand complexes existing in the crystal and in solution, essential in the case of fragment-based screening by X-ray crystallography (FBS-X), has been often an object of controversy. To address this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f0edc4cd22e438607f3d83ec8f7e407f
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4671318&blobtype=pdf