Bruton’s tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress

Autor: Simantini Ghosh, Zaidan Mohammed, Itender Singh

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-26 (2021)

Abstract Background Current therapies targeting several neurotransmitter systems are only able to partially mitigate the symptoms of stress- and trauma-related disorder. Stress and trauma-related disorders lead to a prominent inflammatory response in

Externí odkaz: https://doaj.org/article/ba3b8b4a7fbd4375802e8731b9e8d817

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Data-Driven identification of chemopreventive agents for breast cancer

Autor: Kazim Sahin, Cemal Orhan, Deniz Can Guven, Fatih M. Uckun

Publikováno v: Turkish Journal of Medical Sciences

Preclinical animal models of breast cancer provide the opportunity to identify chemopreventive drugs with single-agent activity as well as effective multi-modality regimens for primary as well as secondary prevention in high-risk persons. Our group h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3fe7aa8d3a7923d22fadf81ba7092f
https://pubmed.ncbi.nlm.nih.gov/32233182

Inhibition of BTK protects lungs from trauma-hemorrhagic shock-induced injury in rats

Autor: Liang-Bi Xiang, Yun-En Liu, Yu Wang, Dapeng Zhou, Zhang Jingdong, Wenfeng Han, Yubiao Zhang, Xinwei Liu

Publikováno v: Molecular Medicine Reports

The present study aimed to investigate the role of Bruton's tyrosine kinase (BTK) in the pathogenesis of lung injury induced by trauma‑hemorrhagic shock (THS), and to examine the pulmonary protective effects of BTK inhibition. Male Sprague‑Dawley

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c08b790189c5bd685442cc093a2192
http://europepmc.org/articles/PMC5482099

Erythropoietin Intensifies the Proapoptotic Activity of LFM-A13 in Cells and in a Mouse Model of Colorectal Cancer

Autor: Robert Czarnomysy, Krystyna Pawlak, Anna Tankiewicz-Kwedlo, Justyna Magdalena Hermanowicz, Izabela Prokop, Krzysztof Bielawski, Dariusz Pawlak

Publikováno v: International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1262
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1262 (2018)
International Journal of Molecular Sciences

The Bruton’s tyrosine kinase (BTK) inhibitor LFM-A13 has been widely employed as an antileukemic agent, but applications in solid cancer have been found recently. The compound promotes apoptosis, has an antiproliferative effect, and increases cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ae26f2e62578de73b347858285d7ce
https://doi.org/10.3390/ijms19041262