Zobrazeno 1 - 10
of 3 509
pro vyhledávání: '"leukotriene receptor"'
Autor:
Yusuke Kito, Kenta Kachi, Michihiro Yoshida, Yasuki Hori, Akihisa Kato, Hidenori Sahashi, Tadashi Toyohara, Kayoko Kuno, Akihisa Adachi, Kenji Urakabe, Hiromi Kataoka
Publikováno v:
Molecules, Vol 29, Iss 14, p 3379 (2024)
Cholangiocarcinoma (CCA) is a cancer with a poor prognosis due to difficulties in diagnosis and limited treatment options, highlighting the urgent need for new targeted therapies. In a clinical setting, we found that leukotriene levels in bile were h
Externí odkaz:
https://doaj.org/article/a155914f12ee4367bebc3489e2cc2937
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Immunotherapy targeting programmed death-ligand 1 (PD-L1) or PD-1 in solid tumors has been shown to be clinically beneficial. However, in colorectal cancer (CRC), only a subset of patients benefit from PD-1/PD-L1 treatment. Previously, we sh
Externí odkaz:
https://doaj.org/article/6e1c476837c84227ba971e19dda7f17c
Autor:
Yuga Yamashita, Kosuke Terada, Yuka Kodama, Ryo Nakadegawa, Hinako Masumitsu, Yuto Motobayashi, Reeko Osada, Hirokazu Takayasu, Nami Masumoto, Takeshi Kaneko, Naomi Tsurikisawa
Publikováno v:
Respiratory Medicine Case Reports, Vol 50, Iss , Pp 102041- (2024)
Introduction: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and aspirin-exacerbated respiratory disease (AERD) have more severe sinus disease than those without AERD. CRSwNP associated with type 2 inflammation and AERD can be diffic
Externí odkaz:
https://doaj.org/article/71ae50105680460da5ab361b5f0fa7da
Autor:
Zhengying Wang, Xiuling Wu, Jinghong Liu, Yu Wang, Yue Zhang, Yan Wu, Yingxue Kang, Ronghai Zhang, Jin Li, Delong Liu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Adenoidal hypertrophy (AH) is one of the most common causes of upper airway obstruction in children. Drug and surgical treatment are the typical treatment of AH. The study on the inflammatory mechanism of AH in children provides a new ide
Externí odkaz:
https://doaj.org/article/39b8063d004344a0b1d01d152213ae26
Publikováno v:
Monaldi Archives for Chest Disease (2023)
The Global Initiative for Asthma (GINA) 2021 guidelines for asthma have been set forth with some alterations in Step 3, for children from 6-11-year-old age group. The low dose LABA-ICS, very low dose formoterol-ICS, medium dose ICS and ICS-LTRA combi
Externí odkaz:
https://doaj.org/article/87c6f6f177004f609633fbb5bf1c978c
Autor:
Margherita Tassan Mazzocco, Valentina Murtaj, Daniel Martins, Roberta Schellino, Angela Coliva, Elisa Toninelli, Alessandro Vercelli, Federico Turkheimer, Sara Belloli, Rosa Maria Moresco
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background One intrastriatal administration of quinolinic acid (QA) in rats induces a lesion with features resembling those observed in Huntington’s disease. Our aim is to evaluate the effects of the cysteinyl leukotriene receptor antagoni
Externí odkaz:
https://doaj.org/article/974ef2f31bcc4b358530cb0116958ea0
Akademický článek
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Autor:
Eman El-Khateeb, Eman I. El-Berri, Esraa M. Mosalam, Mohamed Z. Nooh, Shimaa Abdelsattar, Amira M. Alghamdi, Sarah Alrubia, Mahmoud S. Abdallah
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Type 2 diabetes mellitus (T2DM) is common with obesity. Metformin is a first-line therapy for this condition. However, it has only a minor impact on weight loss in some patients.Aim: This study aimed to evaluate the effectiveness, tolerab
Externí odkaz:
https://doaj.org/article/ab8fabb54ec5483a9b9a4781012c558d
Autor:
E. L. Savlevich, O. M. Kurbacheva, A. V. Zurochka, E. S. Mitrofanova, Yu. S. Smolkin, E. V. Lyubimova
Publikováno v:
Медицинский совет, Vol 0, Iss 8, Pp 111-116 (2022)
Background. Leukotrienes play an important role in the pathogenesis of allergic rhinitis (AR) and eosinophilic type of chronic rhinosinusitis with nasal polyps (CRSwNP). There is a phenotype of CRSwNP in combination with AR, which has specifics of lo
Externí odkaz:
https://doaj.org/article/5159319eaae747649b81c0f50fe48155
Autor:
Nabil V. Sayour, Viktória É. Tóth, Regina N. Nagy, Imre Vörös, Tamás G. Gergely, Zsófia Onódi, Noémi Nagy, Csaba Bödör, Barnabás Váradi, Mihály Ruppert, Tamás Radovits, Federico Bleckwedel, Laura C. Zelarayán, Pal Pacher, Bence Ágg, Anikó Görbe, Péter Ferdinandy, Zoltán V. Varga
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13826 (2023)
The identification of novel drug targets is needed to improve the outcomes of heart failure (HF). G-protein-coupled receptors (GPCRs) represent the largest family of targets for already approved drugs, thus providing an opportunity for drug repurposi
Externí odkaz:
https://doaj.org/article/cf0ec70700ff485780b6aa30bc1f3382