Zobrazeno 1 - 10
of 228
pro vyhledávání: '"leukemia-initiating cells"'
Autor:
Mattia Colucci, Nadia Trivieri, Gandino Mencarelli, Elisabetta De Santis, Francesca Sansico, Francesco Tamiro, Alberto Visioli, Chiara Barile, Riccardo Pracella, Giovanni Rossi, Elena Binda, Vincenzo Giambra
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-5 (2023)
Abstract T-cell lymphoblastic acute leukemia (T-ALL) is an aggressive blood cancer, characterized by restricted cellular subsets with enriched leukemia initiating cells (LICs). Recently, Ephrin receptors (Eph) were described to be highly expressed in
Externí odkaz:
https://doaj.org/article/beb9e41daf6b4f769553c57d5afebeba
Autor:
Majd A. Al-Hamaly, Anna H. Cox, Meghan G. Haney, Wen Zhang, Emma C. Arvin, Shilpa Sampathi, Mary Wimsett, Chunming Liu, Jessica S. Blackburn
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116013- (2024)
The Wnt/β-catenin pathway’s significance in cancer initiation, progression, and stem cell biology underscores its therapeutic potential. However, the clinical application of Wnt inhibitors remains limited due to challenges posed by off-target effe
Externí odkaz:
https://doaj.org/article/76fc5271105e42f49d337f2c63f21788
Autor:
Marta Ibáñez-Navarro, Adrián Fernández, Adela Escudero, Gloria Esteso, Carmen Campos-Silva, Miguel Ángel Navarro-Aguadero, Alejandra Leivas, Beatriz Ruz Caracuel, Carlos Rodríguez-Antolín, Alejandra Ortiz, Alfonso Navarro-Zapata, Carmen Mestre-Durán, Manuel Izquierdo, María Balaguer-Pérez, Cristina Ferreras, Joaquín Martínez-López, Mar Valés-Gómez, Antonio Pérez-Martínez, Lucía Fernández
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionRefractory/relapsed pediatric acute leukemia are still clinically challenging and new therapeutic strategies are needed. Interactions between Natural Killer Group 2D (NKG2D) receptor, expressed in cytotoxic immune cells, and its ligands (
Externí odkaz:
https://doaj.org/article/a050597990ec4b1fb78353f27eb60db9
Autor:
Masashi Numata, Noriyasu Haginoya, Machiko Shiroishi, Tsuyoshi Hirata, Aiko Sato-Otsubo, Kenji Yoshikawa, Yoshimi Takata, Reina Nagase, Yoshinori Kashimoto, Makoto Suzuki, Nina Schulte, Gernot Polier, Akiko Kurimoto, Yumiko Tomoe, Akiko Toyota, Tomoko Yoneyama, Emi Imai, Kenji Watanabe, Tomoaki Hamada, Ryutaro Kanada, Jun Watanabe, Yoshiko Kagoshima, Eri Tokumaru, Kenji Murata, Takayuki Baba, Taeko Shinozaki, Masami Ohtsuka, Koichi Goto, Tsuyoshi Karibe, Takao Deguchi, Yoshihiro Gocho, Masanori Yoshida, Daisuke Tomizawa, Motohiro Kato, Shinji Tsutsumi, Mayumi Kitagawa, Yuki Abe
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Mixed lineage leukemia 1-rearranged (MLL1-r) acute leukemia patients respond poorly to currently available treatments and there is a need to develop more effective therapies directly disrupting the Menin‒MLL1 complex. Small-mole
Externí odkaz:
https://doaj.org/article/f86d0f97c6f6435c8a15c5b3055bcdf2
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/1c6106b8eb2a4713a3fe3e97d8c1912a
Autor:
Alex Q. Lee, Hiroaki Konishi, Connie Duong, Sakiko Yoshida, Ryan R. Davis, Jonathan E. Van Dyke, Masami Ijiri, Bridget McLaughlin, Kyoungmi Kim, Yueju Li, Laurel Beckett, Nitin Nitin, John D. McPherson, Clifford G. Tepper, Noriko Satake
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
In leukemia, a distinct subpopulation of cancer-initiating cells called leukemia stem cells (LSCs) is believed to drive population expansion and tumor growth. Failing to eliminate LSCs may result in disease relapse regardless of the amount of non-LSC
Externí odkaz:
https://doaj.org/article/65345325b8c3492586a08bddfb989d5c
Autor:
Chiqi Chen, Xiaoyun Lai, Yaping Zhang, Li Xie, Zhuo Yu, Sijia Dan, Yu Jiang, Weicai Chen, Ligen Liu, Yi Yang, Dan Huang, Yuzheng Zhao, Junke Zheng
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110607- (2022)
Summary: The mechanism by which redox metabolism regulates the fates of acute myeloid leukemia (AML) cells remains largely unknown. Using a highly sensitive, genetically encoded fluorescent sensor of nicotinamide adenine dinucleotide phosphate (NADPH
Externí odkaz:
https://doaj.org/article/44942171c9e944119752236be600457b
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