Výsledky vyhledávání - "leukaemic stem cell"

Akademický článek

The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia

Autor: Laura Monaghan, Matthew E. Massett, Roderick P. Bunschoten, Alex Hoose, Petrisor-Alin Pirvan, Robert M. J. Liskamp, Heather G. Jørgensen, Xu Huang

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Growing evidence has demonstrated that epigenetic dysregulation is a common pathological feature in human cancer cells. Global alterations in the epigenetic landscape are prevalent in malignant cells across different solid tumors including, prostate

Externí odkaz: https://doaj.org/article/ab95f53a65d24ebca606b6d13543a3fc

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Acute myeloid leukaemia in its niche: the bone marrow microenvironment in acute myeloid leukaemia

Autor: Timothy Chevassut, Andrea Pepper, Eleni E Ladikou, Helena Sivaloganathan

Publikováno v: Current Oncology Reports

Purpose of Review Acute myeloid leukaemia (AML) is a heterogeneous malignancy for which treatment options remain suboptimal. It is clear that a greater understanding of the biology of the AML niche will enable new therapeutic strategies to be develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff38e7b4c48888e5ab5222a822c152e6
http://sro.sussex.ac.uk/id/eprint/92077/3/s11912-020-0885-0.pdf

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Acute myeloid leukaemia niche regulates response to L‐asparaginase

Autor: Bernhard Gentner, Ilaria M. Michelozzi, Carmelo Rizzari, Chiara Tomasoni, Marta Serafini, Francesco Dazzi, Tiziana Coliva, Valentina Granata, Giada De Ponti, Andrea Biondi, Carlo Gambacorti-Passerini, Laura Antolini, Alice Pievani, Gaia Alberti

Publikováno v: British Journal of Haematology
British Journal of Haematology, 186(3), 397-399. Wiley-Blackwell
Kaspers, G J L 2019, ' Acute myeloid leukaemia niche regulates response to L-asparaginase ', British Journal of Haematology, vol. 186, no. 3, pp. 397-399 . https://doi.org/10.1111/bjh.15924

Eradicating the malignant stem cell is the ultimate challenge in the treatment of leukaemia. Leukaemic stem cells (LSC) hijack the normal haemopoietic niche, where they are mainly protected from cytotoxic drugs. The anti-leukaemic effect of L-asparag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c0e14e17c577a072e848f724fd27b9
https://doi.org/10.1111/bjh.15924

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Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species

Autor: Antonieta Chávez-González, Hector Torres-Martinez, Monica L. Guzman, Gabriela Flores‐Lopez, Manuel Ayala-Sánchez, Dafne Moreno-Lorenzana, Peter A. Crooks, Hector Mayani, Sócrates Avilés-Vázquez

Publikováno v: Journal of Cellular and Molecular Medicine

Tyrosine kinase inhibitors (TKI) have become a first‐line treatment for chronic myeloid leuakemia (CML). TKIs efficiently target bulk CML cells; however, they are unable to eliminate the leukaemic stem cell (LSC) population that causes resistance a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5076d6d2282b65d2da2f3c6da50cc620
https://pubmed.ncbi.nlm.nih.gov/30079458

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Chronic myeloid leukaemia

Autor: Debora A. Casolari, Junia V. Melo

Publikováno v: Chromosomal Translocations and Genome Rearrangements in Cancer ISBN: 9783319199825

Chronic myeloid leukaemia (CML) was the first leukaemia associated with a unique genetic abnormality, the Philadelphia chromosome. This results from a reciprocal translocation between chromosomes 9 and 22, which generates the BCR-ABL1 fusion gene enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d122ea227e543427171ec633ad4de6f9
https://hdl.handle.net/11541.2/147925

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