Zobrazeno 1 - 10
of 55
pro vyhledávání: '"leucin rich repeat kinase 2 (LRRK2)"'
Autor:
Laura Cucinotta, Deborah Mannino, Alessia Filippone, Adele Romano, Emanuela Esposito, Irene Paterniti
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Recent studies have demonstrated dysregulation of the autophagy pathway in patients with Parkinson’s disease (PD) and in animal models of PD, highlighting its emerging role in disease. In particular, several studies indicate that autophagy, which i
Externí odkaz:
https://doaj.org/article/90759260df85492492fc9c48bf689ca0
Publikováno v:
British Journal of Medicine and Medical Research. 5:404-408
This work was carried out in collaboration between all authors. Authors ESED suggested the idea of the study, shared in the study design, participated in the practical genomic part and wrote the paper. Author EMK managed the clinical part of the stud
Autor:
Susan S. Taylor, Pallavi Kaila-Sharma, Jui-Hung Weng, Phillip Aoto, Sven H. Schmidt, Stefan Knapp, Sebastian Mathea, Friedrich W. Herberg
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Protein kinases and GTPases are the two major molecular switches that regulate much of biology, and both of these domains are embedded within the large multi-domain Leucine-Rich Repeat Kinase 2 (LRRK2). Mutations in LRRK2 are the most common cause of
Externí odkaz:
https://doaj.org/article/477485f49371480f8b856a22452f7660
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition
Autor:
Manzoni, Claudia, Mamais, Adamantios, Dihanich, Sybille, Soutar, Marc P.M., Plun-Favreau, Helene, Bandopadhyay, Rina, Abeti, Rosella, Giunti, Paola, Hardy, John, R. Cookson, Mark, Tooze, Sharon A., Lewis, Patrick A.
Publikováno v:
Bioscience Reports
Unc-51 Like Kinase 1 (ULK1) is a critical regulator of the biogenesis of autophagosomes, the central component of the catabolic macroautophagy pathway. Regulation of ULK1 activity is dependent upon several phosphorylation events acting to repress or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::03a93a30d01542c2cccd6ceaae7ebf39
https://centaur.reading.ac.uk/76657/9/BSR20171669.full.pdf
https://centaur.reading.ac.uk/76657/9/BSR20171669.full.pdf
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries
Autor:
Tomiyama, Hiroyuki
Publikováno v:
Movement Disorders. 21(8):1102-1108
We screened LRRK2 mutations in exon 41 in 904 parkin-negative Parkinson’s disease (PD) patients (868 probands) from 18 countries across 5 continents. We found 3 heterozygous missense (novel I2012T, G2019S, and I2020T) mutations in LRRK2 exon 41. We
Autor:
Brandt, Annette1 (AUTHOR) annette.brandt@univie.ac.at, Kopp, Florian2 (AUTHOR) florian.kopp@univie.ac.at
Publikováno v:
International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5678. 15p.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Najib, Yahaya Sani1,2 najibsani62@student.usm.my, Ayipo, Yusuf Oloruntoyin1,3, Alananzeh, Waleed Abdullah Ahmad1, Muhammed, Mustapha4, Mordi, Mohd Nizam1
Publikováno v:
Malaysian Journal of Medicine & Health Sciences. Nov2023, Vol. 19 Issue 6, p83-94. 12p.