Zobrazeno 1 - 10
of 617
pro vyhledávání: '"let-7a"'
Autor:
Ines Barone, Luca Gelsomino, Felice Maria Accattatis, Francesca Giordano, Balazs Gyorffy, Salvatore Panza, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Daniela Bonofiglio, Sebastiano Andò, Cinzia Giordano, Stefania Catalano
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background The incidence of obesity, a known risk factor for several metabolic and chronic diseases, including numerous malignancies, has risen sharply in the world. Various clinical studies demonstrate that excessive Body Mass Index (BMI) m
Externí odkaz:
https://doaj.org/article/d9475bfb0f4d4b1b8100b39276f4b3ce
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 7, Pp 1584-1590 (2023)
Neurotrophic factors, particularly nerve growth factor, enhance neuronal regeneration. However, the in vivo applications of nerve growth factor are largely limited by its intrinsic disadvantages, such as its short biological half-life, its contributi
Externí odkaz:
https://doaj.org/article/3cf323ab8015405a89b27f97c3c10173
Autor:
Masahiro Yura, Kazumasa Fukuda, Satoru Matsuda, Tomoyuki Irino, Rieko Nakamura, Hirofumi Kawakubo, Hiroya Takeuchi, Yuko Kitagawa
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background C–C chemokine receptor type 7 (CCR7) participates in chemotactic and metastatic responses in various cancers, including in esophageal squamous cell carcinoma (ESCC). The microRNA (miRNA) let-7a suppresses migration and invasion
Externí odkaz:
https://doaj.org/article/5b70296dcfc0484984b1ef71ae066e86
Akademický článek
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Publikováno v:
Jichu yixue yu linchuang, Vol 42, Iss 6, Pp 857-863 (2022)
Objective To establish effective CRISPR/Cas9 system targeting mouse miR let-7a. Methods Two pairs of dual-sgRNAs sequences were designed according to the coding sequences of two coding sites let-7a-1 and let-7a-2 of mouse let-7a respectively. The tar
Externí odkaz:
https://doaj.org/article/f8171424e4c941cf98b110bd4a0e81bd
Autor:
Xueqin Wang, Tiandi Xiong, Miao Cui, Na Li, Qin Li, Li Zhu, Shaofeng Duan, Yunlong Wang, Yuqi Guo
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background Multidrug resistance (MDR) is the main challenge of successful chemotherapy for ovarian cancer patients, with 50% to 75% of ovarian cancer patients eventually relapsed due to it. One of the effective strategies for treating MDR an
Externí odkaz:
https://doaj.org/article/f101d0f148f043f1bbbb57fb4f5b15a1
Publikováno v:
Cell Journal, Vol 23, Iss 5, Pp 532-537 (2021)
Objective: Ionizing radiation is a tremendous risk factor for cancer development. MicroRNAs (miRNAs) are regulators that utilize cell pathways, which are implicated in human cancer prognosis. In addition, miRNAs respond to anti-cancer therapy and pro
Externí odkaz:
https://doaj.org/article/db3d552637434aaf8af30414edd2e9aa
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Background Let-7a is a small non-coding RNA that has been found to take part in cell proliferation and apoptosis. The hippo-YAP1 axis, known as a tumour suppressor pathway, also plays an important role in cell proliferation and apoptosis. YA
Externí odkaz:
https://doaj.org/article/7fcaa14f9201413b9714b9a3c2fde381
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-16 (2021)
Abstract Background Cholangiocarcinoma (CCA) is the second most common primary liver malignancy worldwide. Several microRNAs (miRNAs) have been implicated as potential tumor suppressors in CCA. This study aims to explore the potential effects of miR-
Externí odkaz:
https://doaj.org/article/1a70a9d926214be9a6e608d628ac7a61