Intrathecal methotrexate injection combined treatment of gastric cancer with leptomeningeal metastasis: case report

Autor: Wenting Xie, Xun Kang, Sijie Huang, Wenbin Li

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundLeptomeningeal metastasis of gastric adenocarcinoma (LM-GC) is a rare and severe complication with a poor prognosis, its prognosis is significantly poorer than liver, lung, and peritoneal metastases. Studies on LM-GC have been limited to cl

Externí odkaz: https://doaj.org/article/35f070ba1021472b888e4d707a10b6e8

Case report: Cerebrospinal fluid-derived circulating tumor DNA diagnoses and guides the treatment of a lung adenocarcinoma case with leptomeningeal metastasis

Autor: Yujun Bai, Qingxi Yu, Ning Liu, Jingwen Liu, Di Wang, Xiaoli Liu, Shuanghu Yuan

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Leptomeningeal metastasis (LM) occurs in 3~5% of non-small cell lung cancer (NSCLC) patients. Diagnosis of patients with LM and disease monitoring remains challenging due to the low sensitivity and specificity of the commonly used approaches, such as

Externí odkaz: https://doaj.org/article/00de735b63c647a2b765a69e07bf680c

Deep Learning-Based Classification of Cancer Cell in Leptomeningeal Metastasis on Cytomorphologic Features of Cerebrospinal Fluid

Autor: Wenjin Yu, Yangyang Liu, Yunsong Zhao, Haofan Huang, Jiahao Liu, Xiaofeng Yao, Jingwen Li, Zhen Xie, Luyue Jiang, Heping Wu, Xinhao Cao, Jiaming Zhou, Yuting Guo, Gaoyang Li, Matthew Xinhu Ren, Yi Quan, Tingmin Mu, Guillermo Ayuso Izquierdo, Guoxun Zhang, Runze Zhao, Di Zhao, Jiangyun Yan, Haijun Zhang, Junchao Lv, Qian Yao, Yan Duan, Huimin Zhou, Tingting Liu, Ying He, Ting Bian, Wen Dai, Jiahui Huai, Xiyuan Wang, Qian He, Yi Gao, Wei Ren, Gang Niu, Gang Zhao

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

BackgroundIt is a critical challenge to diagnose leptomeningeal metastasis (LM), given its technical difficulty and the lack of typical symptoms. The existing gold standard of diagnosing LM is to use positive cerebrospinal fluid (CSF) cytology, which

Externí odkaz: https://doaj.org/article/e7b0a8fca6b94cddb29f45c522794095

Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid

Autor: Pablo Juanes-Velasco, Norma Galicia, Elisa Pin, Ricardo Jara-Acevedo, Javier Carabias-Sánchez, Rodrigo García-Valiente, Quentin Lecrevisse, Carlos Eduardo Pedreira, Rafael Gongora, Jose Manuel Sanchez-Santos, Héctor Lorenzo-Gil, Alicia Landeira-Viñuela, Halin Bareke, Alberto Orfao, Peter Nilsson, Manuel Fuentes

Publikováno v: Cancers
Cancers, Vol 14, Iss 449, p 449 (2022)
Cancers; Volume 14; Issue 2; Pages: 449
Cancers, 14(2):449. Multidisciplinary Digital Publishing Institute (MDPI)

In the present work, leptomeningeal disease, a very destructive form of systemic cancer, was characterized from several proteomics points of view. This pathology involves the invasion of the leptomeninges by malignant tumor cells. The tumor spreads t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9da16ee668976c2fe689d3b4baee71b
https://doi.org/10.3390/cancers14020449

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