Zobrazeno 1 - 10
of 1 325
pro vyhledávání: '"leptomeningeal metastases"'
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Leptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly detrimental occurrence associated with severe neurological disorders, lacking effective treatment currently. Proteolysis-targeting chimeric molecules (PRO
Externí odkaz:
https://doaj.org/article/259e884ace1e40e6be1be643dfc7119a
Autor:
Jia-Xin Lin, PhD, Kai Yin, PhD, Li-Xu Yan, PhD, Mei-Mei Zheng, PhD, Yang-Si Li, PhD, Shi-Ling Zhang, MS, Kang-Hui Zeng, MS, Hong-Hong Yan, MS, Hai-Yan Tu, PhD, Zhi-Hong Chen, MS, Xu-Chao Zhang, PhD, Qing Zhou, PhD, Jin-Ji Yang, PhD, Ben-Yuan Jiang, PhD, Qing-Ling Zhang, PhD, Yi-Long Wu, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 9, Pp 100704- (2024)
Introduction: Transformation to SCLC is a resistance mechanism to tyrosine kinase inhibitor in EGFR-mutated lung adenocarcinoma (LUAD). Nevertheless, the clinical and molecular features of SCLC transformation in LUAD with leptomeningeal metastases (L
Externí odkaz:
https://doaj.org/article/8dfa85064813427d9f719ff4ce66f49e
Autor:
Xiaoyu Hua, Weifeng Feng, Minting Ye, Mingyao Lai, Xiaojun Yu, Mengnan Sun, Juan Li, Ruyu Ai, Yanlin He, Linbo Cai, Changzheng Shi, Xiangning Liu
Publikováno v:
Cancer Medicine, Vol 13, Iss 9, Pp n/a-n/a (2024)
Abstract Background The goal of this study was to create a nomogram using routine parameters to predict leptomeningeal metastases (LMs) in advanced lung adenocarcinoma (LAC) patients to prevent needless exams or lumbar punctures and to assist in accu
Externí odkaz:
https://doaj.org/article/76ca4ae495b6402ab953cd61a948b187
Autor:
Lei Wen, Junjie Zhen, Changguo Shan, Mingyao Lai, Weiping Hong, Hui Wang, Mingting Ye, Yanying Yang, Shaoqun Li, Zhaoming Zhou, Jiangfen Zhou, Qingjun Hu, Juan Li, Xuwei Tian, Longhua Chen, Linbo Cai, Zhanhong Xie, Cheng Zhou
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-10 (2023)
Abstract Background The aim of this study was to evaluate the efficacy and safety of osimertinib for the treatment of leptomeningeal metastases (LM) from epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). Methods We co
Externí odkaz:
https://doaj.org/article/454a4a5e0787433c981edeea599115a0
Publikováno v:
The Clinical Respiratory Journal, Vol 18, Iss 2, Pp n/a-n/a (2024)
Abstract Background Leptomeningeal metastasis (LM) is a lethal complication of advanced lung cancer, and due to limited access to the leptomeningeal lesion, we explored the potential role of cerebrospinal fluid (CSF) as a source for liquid biopsy in
Externí odkaz:
https://doaj.org/article/3a46d54caa464719ad061e5ed14f9655
Autor:
Xiaocui Liu, Fengjun Mei, Mei Fang, Yaqiong Jia, Yazhu Zhou, Chenxi Li, Panpan Tian, Chufan Lu, Guangrui Li
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundBrain metastases (BM), including brain parenchyma metastases (BPM) and leptomeningeal metastases (LM), are devastating metastatic complications in advanced cancer patients. Next-generation sequencing (NGS) is emerging as a new promising too
Externí odkaz:
https://doaj.org/article/10c4fa06c0e141eea60142ced3edf842
Autor:
Xin Chen, Kaixuan Bai, Yu Zhang, Yang Xu, Yinghao Huo, Sha Wang, Yueli Zou, Xuejiao Qi, Rongyun Guo, Qiuxiang Ou, Dengxiang Liu, Shaohua Yin, Shubo Chen, Hui Bu
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Leptomeningeal metastases (LM) were rare in gastric cancer (GC), and GC patients with LM (GCLM) generally suffer from poor prognosis. Nevertheless, the clinical utility of cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) wa
Externí odkaz:
https://doaj.org/article/a0cf73e822df49d7a4935642eb6d3ae9
Akademický článek
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Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e20690- (2023)
Background: Advanced non-small cell lung cancer (NSCLC) is often complicated by leptomeningeal metastases (LMs), especially in patients carrying EGFR mutations. EGFR tyrosine kinase inhibitors (TKIs) are the first-line drug for patients with specific
Externí odkaz:
https://doaj.org/article/445e225c20e74bcf9a78c7ad2d5e12cd
Autor:
Cheng Jiang, Yongjuan Lin, Huiying Li, Yu Xie, Tingting Yu, Jingyu Feng, Mingmin Huang, Aibin Guo, Haiyun Shen, YiDan Zhang, Zhenyu Yin
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 6913-6923 (2023)
Abstract Objectives To explore the diagnostic accuracy of ultrasound measurement of optic nerve sheath diameter (ONSD) and optic disc height (ODH) in detecting intracranial hypertension in non‐small‐cell lung cancer (NSCLC) patients with leptomen
Externí odkaz:
https://doaj.org/article/6902bea395ea497d98a2483cd0a2948a