Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer

Autor: le Sage Carlos, Meijer Gerrit A, Diosdado Begoňa, Meijer Chris JLM, Henken Florianne E, van Boerdonk Robert AA, Wilting Saskia M, Agami Reuven, Snijders Peter JF, Steenbergen Renske DM

Publikováno v: Molecular Cancer, Vol 9, Iss 1, p 167 (2010)

Abstract Background A substantial number of microRNAs (miRNAs) is subject to epigenetic silencing in cancer. Although epigenetic silencing of tumour suppressor genes is an important feature of cervical cancer, little is known about epigenetic silenci

Externí odkaz: https://doaj.org/article/0b9121ba64c34b1f8e877da563aabf3d

CRISPR: A Screener’s Guide

Autor: le Sage, Carlos, Lawo, Steffen, Cross, Benedict C.S. ^*

Publikováno v: In SLAS Discovery March 2020 25(3):233-240

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Synthetic lethality between PAXX and XLF in mammalian development

Autor: Balmus, Gabriel, Barros, Ana C, Wijnhoven, Paul WG, Lescale, Chloé, Hasse, Hélène Lenden, Boroviak, Katharina, Le Sage, Carlos, Doe, Brendan, Speak, Anneliese O, Galli, Antonella, Jacobsen, Matt, Deriano, Ludovic, Adams, David J, Blackford, Andrew N, Jackson, Stephen P

Publikováno v: Genes and Development
Genes and Development, 2016, 30 (19), pp.2152-2157. ⟨10.1101/gad.290510.116⟩
Genes and Development, Cold Spring Harbor Laboratory Press, 2016, 30 (19), pp.2152-2157. ⟨10.1101/gad.290510.116⟩

International audience; PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf −/− mice, Paxx −/− mice are viable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c288771b2e0d0d3295b2ff0ee30641df
https://hal-pasteur.archives-ouvertes.fr/pasteur-01416628/document

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