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Akademický článek

Patient-derived organoids identify tailored therapeutic options and determinants of plasticity in sarcomatoid urothelial bladder cancer

Autor: Michele Garioni, Viviane J. Tschan, Lauriane Blukacz, Sandro Nuciforo, Romuald Parmentier, Luca Roma, Mairene Coto-Llerena, Heike Pueschel, Salvatore Piscuoglio, Tatjana Vlajnic, Frank Stenner, Hans-Helge Seifert, Cyrill A. Rentsch, Lukas Bubendorf, Clémentine Le Magnen

Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)

Abstract Sarcomatoid Urothelial Bladder Cancer (SARC) is a rare and aggressive histological subtype of bladder cancer for which therapeutic options are limited and experimental models are lacking. Here, we report the establishment of a long-term 3D o

Externí odkaz: https://doaj.org/article/bcfa1bd34b2c4ad09ce019db7e34e4ca

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Akademický článek

Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer

Autor: Tatjana Vlajnic, David C. Müller, Christian Ruiz, René Schönegg, Hans‐Helge Seifert, George N. Thalmann, Tobias Zellweger, Clémentine Le Magnen, Cyrill A. Rentsch, Lukas Bubendorf

Publikováno v: Cancer Reports, Vol 7, Iss 2, Pp n/a-n/a (2024)

Abstract Background Prostate cancer is morphologically and molecularly heterogeneous. Genomic heterogeneity might be mirrored by variability in DNA ploidy. Aneuploidy is a hallmark of genomic instability and associated with tumor aggressiveness. Litt

Externí odkaz: https://doaj.org/article/a2b85cdb7c2c4431931d36a19a3d0d6e

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Akademický článek

Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer

Autor: Bachmann Alexander, Provenzano Maurizio, Bubendorf Lukas, Yousef Kawa, Trella Emanuele, Le Magnen Clémentine, Mengus Chantal, Heberer Michael, Spagnoli Giulio C, Wyler Stephen

Publikováno v: Journal of Translational Medicine, Vol 9, Iss 1, p 162 (2011)

Abstract Background Chronic inflammation has been suggested to favour prostate cancer (PCA) development. Interleukins (IL) represent essential inflammation mediators. IL-2, IL-7, IL-15 and IL-21, sharing a common receptor γ chain (c-γ), control T l

Externí odkaz: https://doaj.org/article/550a2132372a4199b7a76b95d691e506

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