Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey

Autor: Soekmadji, Carolina, Hill, Andrew F, Wauben, Marca H, Buzás, Edit I, Di Vizio, Dolores, Gardiner, Chris, Lötvall, Jan, Sahoo, Susmita, Witwer, Kenneth W, dB&C I&I, LS Celbiologie-Algemeen

Publikováno v: Journal of Extracellular Vesicles, Vol 7, Iss 1 (2018)
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, 7(1). Co-Action Publishing

The discovery that extracellular vesicles (EVs) can transfer functional extracellular RNAs (exRNAs) between cells opened new avenues into the study of EVs in health and disease. Growing interest in EV RNAs and other forms of exRNA has given rise to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e1dfc2bfc065fba887358643d27d24

Urinary Metabolomic Markers of Protein Glycation, Oxidation, and Nitration in Early-Stage Decline in Metabolic, Vascular, and Renal Health

Autor: Jinit Masania, Gernot Faustmann, Attia Anwar, Hildegard Hafner-Giessauf, Nasir Rajpoot, Johanna Grabher, Kashif Rajpoot, Beate Tiran, Barbara Obermayer-Pietsch, Brigitte M. Winklhofer-Roob, Johannes M. Roob, Naila Rabbani, Paul J. Thornalley

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)

Glycation, oxidation, nitration, and crosslinking of proteins are implicated in the pathogenic mechanisms of type 2 diabetes, cardiovascular disease, and chronic kidney disease. Related modified amino acids formed by proteolysis are excreted in urine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020a46a54444b7bd1833c9883eaab48f

A protocol for cell therapy infusion in neonates

Autor: Susan E Jacobs, Peter G Davis, Atul Malhotra, Stuart B. Hooper, Elizabeth K. Baker, Rebecca Lim, Euan M. Wallace

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 5, Pp 773-780 (2021)
Stem Cells Translational Medicine

Cell therapies for neonatal morbidities are progressing to early phase clinical trials. However, protocols for intravenous (IV) delivery of cell therapies to infants have not been evaluated. It has been assumed the cell dose prescribed is the dose de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9206784f9523bed3f26b47b74ade6470
https://doaj.org/article/ea0c55e778334a63926881486b1eee8a

Protecting islet functional viability using mesenchymal stromal cells

Autor: Peter B. Jones, Chloe L. Rackham, Ella L. Hubber

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 5, Pp 674-680 (2021)
Stem Cells Translational Medicine

Islet transplantation is an emerging treatment for type 1 diabetes which offers the prospect of physiological control of blood glucose and reductions in acute hypoglycaemic episodes. However, current protocols are limited by a rapid decline in islet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea3e4e238420f3c54f48058ec897f4a
https://doaj.org/article/f394ca273ba6448f997c2644f9d607cc

Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway

Autor: Keting Bao, Jinlian Wei, Jian Li, Renbing Jia, Jie Yang, Jin Zhu, Jiahao Shi, Yongyun Li, Fei Mao, Li Ruoxi, Baoli Li

Publikováno v: Cell Death and Disease, Vol 12, Iss 4, Pp 1-11 (2021)
Cell Death & Disease

Conjunctival melanoma (CM) is a rare and fatal ocular tumour with poor prognosis. There is an urgent need of effective therapeutic drugs against CM. Here, we reported the discovery of a novel potential therapeutic target for CM. Through phenotypic sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9588d994c84b2d1b2229bc79701b46d1
https://doaj.org/article/cc5d174684044e10bf85677795875528