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Akademický článek

Recombinant YopE and LcrV vaccine candidates protect mice against plague and yersiniosis

Autor: Ankit Gupta, Pooja Mahajan, Sameer S. Bhagyawant, Nandita Saxena, Atul Kumar Johri, Subodh Kumar, Shailendra Kumar Verma

Publikováno v: Heliyon, Vol 10, Iss 10, Pp e31446- (2024)

No licensed vaccine exists for the lethal plague and yersiniosis. Therefore, a combination of recombinant YopE and LcrV antigens of Yersinia pestis was evaluated for its vaccine potential in a mouse model. YopE and LcrV in formulation with alum impar

Externí odkaz: https://doaj.org/article/d6cfef988d7d4f24869e03abf5de5211

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Akademický článek

Direct Quantification of Protein Antigens in Subunit Plague and Rickettsial Vaccine Preparations

Autor: P. Kh. Kopylov, S. V. Dentovskaya

Publikováno v: Проблемы особо опасных инфекций, Vol 0, Iss 4, Pp 69-74 (2023)

The aim of the work was to put forward the methods for direct quantitative determination of the content of Yersinia pestis and Rickettsia raoultii protein antigens in preparations and various prototypes of subunit vaccines. Materials and methods. Y.

Externí odkaz: https://doaj.org/article/f9501d926b3f4f15b13b42341e788401

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Akademický článek

Rapid Induction of Protective Immunity against Pneumonic Plague by Yersinia pestis Polymeric F1 and LcrV Antigens

Autor: Moshe Aftalion, Avital Tidhar, Yaron Vagima, David Gur, Ayelet Zauberman, Tzvi Holtzman, Arik Makovitzki, Theodor Chitlaru, Emanuelle Mamroud, Yinon Levy

Publikováno v: Vaccines, Vol 11, Iss 3, p 581 (2023)

In a recent study, we demonstrated that vaccination with the polymeric F1 capsule antigen of the plague pathogen Yersinia pestis led to the rapid induction of a protective humoral immune response via the pivotal activation of innate-like B1b cells. C

Externí odkaz: https://doaj.org/article/555ae72ec4e946c7902499b5bb357e6e

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Akademický článek

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Akademický článek

Interactions between Yersinia pestis V-antigen (LcrV) and human Toll-like receptor 2 (TLR2) in a modelled protein complex and potential mechanistic insights

Autor: Tiandi Wei, Jing Gong, Guojing Qu, Mingyu Wang, Hai Xu

Publikováno v: BMC Immunology, Vol 20, Iss 1, Pp 1-9 (2019)

Abstract Background Yersinia pestis, the etiological pathogen of plague, is capable of repressing the immune response of white blood cells to evade phagocytosis. The V-antigen (LcrV) was found to be involved in this process by binding to human Toll-l

Externí odkaz: https://doaj.org/article/7e561e19f8a84527ba747923c294cc20

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Akademický článek

Polymorphism in the Yersinia LcrV Antigen Enables Immune Escape From the Protection Conferred by an LcrV-Secreting Lactococcus Lactis in a Pseudotuberculosis Mouse Model

Autor: Catherine Daniel, Amélie Dewitte, Sabine Poiret, Michaël Marceau, Michel Simonet, Laure Marceau, Guillaume Descombes, Denise Boutillier, Nadia Bennaceur, Sébastien Bontemps-Gallo, Nadine Lemaître, Florent Sebbane

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Yersinioses caused by Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica are significant concerns in human and veterinary health. The link between virulence and the potent LcrV antigen has prompted the latter's selection as a m

Externí odkaz: https://doaj.org/article/107c68211f19498890336f73d2e61cf1

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Bimolecular fluorescence complementation assay to explore protein-protein interactions of the Yersinia virulence factor YopM

Autor: Özge Uğurlu, Serap Evran

Publikováno v: Biochemical and Biophysical Research Communications. 582:43-48

Yersinia outer protein M (YopM) is one of the effector proteins and essential for virulence. YopM is delivered by the Yersinia type III secretion system (T3SS) into the host cell, where it shows immunosuppressive effect through interaction with host

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3e0d9f797787405cc5ddce1bda586f
https://doi.org/10.1016/j.bbrc.2021.10.039

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CD4+ T-Cell Epitope Prediction by Combined Analysis of Antigen Conformational Flexibility and Peptide-MHCII Binding Affinity

Autor: Daniel L. Moss, Samuel J. Landry, Kummer A Nicholas, Tysheena P. Charles, Pawan Bhat, Avik Bhattacharya, Ramgopal R. Mettu, Peyton W Moore

Publikováno v: Biochemistry. 61:1585-1599

Antigen processing in the class II MHC pathway depends on conventional proteolytic enzymes, potentially acting on antigens in native-like conformational states. CD4+ epitope dominance arises from a competition between antigen folding, proteolysis, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fd1ddf983f30c6a16cb92459280f0f
https://doi.org/10.1021/acs.biochem.2c00237

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Akademický článek

Epitope Binning of Novel Monoclonal Anti F1 and Anti LcrV Antibodies and Their Application in a Simple, Short, HTRF Test for Clinical Plague Detection

Autor: Adva Mechaly, Einat B. Vitner, Yinon Levy, David Gur, Moria Barlev-Gross, Assa Sittner, Michal Koren, Haim Levy, Emanuelle Mamroud, Morly Fisher

Publikováno v: Pathogens, Vol 10, Iss 3, p 285 (2021)

Mouse monoclonal antibodies were raised against plague disease biomarkers: the bacterial capsular protein fraction 1 (F1) and the low-calcium response—LcrV virulence factor (Vag). A novel tandem assay, employing BioLayer Interferometry (BLI), enabl

Externí odkaz: https://doaj.org/article/c857d46183084f8b9b0b846777cc04da

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Akademický článek

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