Zobrazeno 1 - 10
of 102
pro vyhledávání: '"latency reversal agents"'
Autor:
Erick De La Torre Tarazona, Caroline Passaes, Santiago Moreno, Asier Sáez-Cirión, José Alcamí
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Maraviroc (MVC) is an antiretroviral drug capable of binding to CCR5 receptors and block HIV entry into target cells. Moreover, MVC can activate NF-kB pathway and induce viral transcription in HIV-infected cells, being proposed as a latency
Externí odkaz:
https://doaj.org/article/0e11a0a1d69042ada533cb96292a1509
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The HIV-1 reservoirs harbor the latent proviruses that are integrated into the host genome. It is a challenging task to eradicate the proviruses in order to achieve an HIV cure. We have described a strategy for the clearance of HIV-1 infection throug
Externí odkaz:
https://doaj.org/article/1b9e9a41472a4aa5b8764fd218044875
Autor:
Ifeanyi Jude Ezeonwumelu, Edurne García-Vidal, Eudald Felip, Maria C. Puertas, Bruna Oriol-Tordera, Lucía Gutiérrez-Chamorro, André Gohr, Marta Ruiz-Riol, Marta Massanella, Bonaventura Clotet, Javier Martinez-Picado, Roger Badia, Eva Riveira-Muñoz, Ester Ballana
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contrib
Externí odkaz:
https://doaj.org/article/0c134c9371f546d1bf28e34f8645f39a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The main obstacle to cure HIV-1 is the latent reservoir. Antiretroviral therapy effectively controls viral replication, however, it does not eradicate the latent reservoir. Latent CD4+ T cells are extremely rare in HIV-1 infected patients, making pri
Externí odkaz:
https://doaj.org/article/aff97d86d87a4ae484b3cf27ee546180
Autor:
Sadia Samer, Muhammad Shoaib Arif, Leila Bertoni Giron, Jean Paulo Lopes Zukurov, James Hunter, Bruna Teresa Santillo, Gislene Namiyama, Juliana Galinskas, Shirley Vasconcelos Komninakis, Telma Miyuki Oshiro, Maria Cecilia Sucupira, Luiz Mario Janini, Ricardo Sobhie Diaz
Publikováno v:
Brazilian Journal of Infectious Diseases, Vol 24, Iss 2, Pp 150-159 (2020)
Background: Latent HIV-1 is a major hurdle in obtaining HIV-1 sustained virological remission (SVR). Here we explored histone deacetylation inhibition property of nicotinamide (NAM; n = 17) for the first time in comparison to a combination of methylt
Externí odkaz:
https://doaj.org/article/dc4c4bab15404e79a03bd50da2bb1f03
Publikováno v:
Viruses, Vol 15, Iss 3, p 789 (2023)
Chimeric antigen receptor (CAR) technology is having a huge impact in the blood malignancy field and is becoming a well-established therapy for many types of leukaemia. In recent decades, efforts have been made to demonstrate that CAR-T cells have po
Externí odkaz:
https://doaj.org/article/0bf3222812cd41f2b6c427c4db33521b
Autor:
Ignacio Relaño-Rodríguez, Raquel Juárez-Sánchez, Carolina Pavicic, Eduardo Muñoz, Maria Ángeles Muñoz-Fernández
Publikováno v:
Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-8 (2019)
Abstract Background The major obstacle impeding human immunodeficiency virus-1 (HIV-1) eradication in antiretroviral treatment (ART) treated HIV-1 subjects is the establishment of long-lived latently infected resting CD4+ T cells. Due to the fact tha
Externí odkaz:
https://doaj.org/article/3dcf834c34b24e52bccda46d3e421ae9
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Indra Sarabia, Camille L. Novis, Amanda B. Macedo, Hiroshi Takata, Racheal Nell, Juyeon C. Kakazu, Robert L. Furler, Binita Shakya, Heidi L. Schubert, Christopher P. Hill, Ana Beatriz DePaula-Silva, Adam M. Spivak, Lydie Trautmann, Vicente Planelles, Alberto Bosque
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The mitochondrial antiviral signaling protein (MAVS) is part of the cell’s innate immune mechanism of defense. MAVS mRNA is bicistronic and can give rise to a full length-MAVS and a shorter isoform termed miniMAVS. In response to viral infections,
Externí odkaz:
https://doaj.org/article/2d9d89e2d68d41a7894a9b45ae46dc68