Zobrazeno 1 - 10
of 509
pro vyhledávání: '"large animal models"'
Autor:
Constantin von Bibra, Rabea Hinkel
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Non-human primates (NHP) are valuable models for late translational pre-clinical studies, often seen as a last step before clinical application. The unique similarity between NHPs and humans is often the subject of ethical concerns. However, it is pr
Externí odkaz:
https://doaj.org/article/a752489fbefc43fcba40ad8146f704e5
Publikováno v:
MethodsX, Vol 12, Iss , Pp 102549- (2024)
The aim of this study was to create a continuous drug delivery system that would yield serum testosterone levels in sexually mature, female pigs consistent with serum testosterone levels of human transgender men. Testosterone enanthate was mixed with
Externí odkaz:
https://doaj.org/article/873d4a1ff1244635a9bd0b6e7e50f422
Akademický článek
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Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Traumatic brain injury (TBI) often results in prolonged or permanent brain dysfunction with over 2.8 million affected annually in the U.S., including over 56,000 deaths, with over 5 million total survivors exhibiting chronic deficits. Mild T
Externí odkaz:
https://doaj.org/article/389556e4d336474590c65b9adf8eac83
Publikováno v:
BIO Integration, Vol 3, Iss 4, Pp 161-171 (2022)
Large-animal models show greater advantages than rodents in recapitulating human genetic diseases, primarily because of their higher similarity to humans in terms of anatomy, physiology and genetics. Notably, as genome-editing technologies have rapid
Externí odkaz:
https://doaj.org/article/8b5637b1b77049fb95e04dabb1ae44c1
Autor:
Laura M. Schreiber, David Lohr, Steffen Baltes, Ulrich Vogel, Ibrahim A. Elabyad, Maya Bille, Theresa Reiter, Aleksander Kosmala, Tobias Gassenmaier, Maria R. Stefanescu, Alena Kollmann, Julia Aures, Florian Schnitter, Mihaela Pali, Yuichiro Ueda, Tatiana Williams, Martin Christa, Ulrich Hofmann, Wolfgang Bauer, Brenda Gerull, Alma Zernecke, Süleyman Ergün, Maxim Terekhov
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
A key step in translational cardiovascular research is the use of large animal models to better understand normal and abnormal physiology, to test drugs or interventions, or to perform studies which would be considered unethical in human subjects. Ul
Externí odkaz:
https://doaj.org/article/9193eef9bf9242b49f87492d8e2116d8
Autor:
Yuexin Yu, Seng Kong Tham, Fatin Fazrina Roslan, Bakiah Shaharuddin, Yoke Keong Yong, Zhikun Guo, Jun Jie Tan
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Myocardial infarction is the most common cause of heart failure, one of the most fatal non-communicable diseases worldwide. The disease could potentially be treated if the dead, ischemic heart tissues are regenerated and replaced with viable and func
Externí odkaz:
https://doaj.org/article/b2346091551d40dd9035bd50291bbbf0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Gynecological diseases are a series of diseases caused by abnormalities in the female reproductive organs or breast, which endanger women’s fertility and even their lives. Therefore, it is important to investigate the mechanism of occurrence and tr
Externí odkaz:
https://doaj.org/article/05d17f1363eb4a58a7d3940752610d1b
Autor:
Pavel Vintrych, Mahmoud Al-Obeidallah, Jan Horák, Jiří Chvojka, Lenka Valešová, Lukáš Nalos, Dagmar Jarkovská, Martin Matějovič, Milan Štengl
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Infectious diseases, which often result in deadly sepsis or septic shock, represent a major global health problem. For understanding the pathophysiology of sepsis and developing new treatment strategies, reliable and clinically relevant animal models
Externí odkaz:
https://doaj.org/article/3068e7baecca4e37a990f4764f68e4c2