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Akademický článek

Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice

Autor: Bartłomiej Pochwat, Paulina Misztak, Julia Masternak, Ewa Bączyńska, Krystian Bijata, Matylda Roszkowska, Monika Bijata, Jakub Włodarczyk, Małgorzata Szafarz, Elżbieta Wyska, Bożena Muszyńska, Agata Krakowska, Włodzimierz Opoka, Gabriel Nowak, Bernadeta Szewczyk

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Clinical and preclinical studies show evidence that chronic stress or nutritional deficits in dietary zinc (Zn) intake may be risk factors for developing major depressive disorder (MDD). Furthermore, there may be possible links between low serum Zn l

Externí odkaz: https://doaj.org/article/b358d4e3043d414eb1864ae94ad23e41

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Akademický článek

Does mismatch negativity have utility for NMDA receptor drug development in depression?

Autor: Nicholas Murphy, Marijn Lijffijt, Nithya Ramakrishnan, Bylinda Vo-Le, Brittany Vo-Le, Sidra Iqbal, Tabish Iqbal, Brittany O’Brien, Mark A. Smith, Alan C. Swann, Sanjay J. Mathew

Publikováno v: Brazilian Journal of Psychiatry (2021)

Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model. Treatment with ketamine, an N-methyl-D-aspartat

Externí odkaz: https://doaj.org/article/13dbf57d926c4b788c528731005ad3d2

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Does mismatch negativity have utility for NMDA receptor drug development in depression?

Autor: Mark A. Smith, Sidra Iqbal, Alan C. Swann, Marijn Lijffijt, Nithya Ramakrishnan, Sanjay J. Mathew, Tabish Iqbal, Brittany Vo-Le, Brittany O'Brien, Bylinda Vo-Le, Nicholas Murphy

Publikováno v: Brazilian Journal of Psychiatry (2021)
Brazilian Journal of Psychiatry v.44 n.1 2022
Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
Brazilian Journal of Psychiatry, Volume: 44, Issue: 1, Pages: 61-73, Published: 05 APR 2021
Brazilian Journal of Psychiatry, Issue: ahead, Published: 05 APR 2021

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ed813a67be50558d8f06369dfe279e
https://doi.org/10.1590/1516-4446-2020-1685

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Akademický článek

Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate

Autor: Downey, Darragh ^a, Dutta, Arpan ^{a, ⁎}, McKie, Shane ^a, Dawson, Gerard R. ^b, Dourish, Colin T. ^b, Craig, Kevin ^{b, 1}, Smith, Mark A. ^{c, 1}, McCarthy, Dennis J. ^{c, 1}, Harmer, Catherine J. ^d, Goodwin, Guy M. ^d, Williams, Steve ^a, Deakin, J.F. William ^{a, e}

Publikováno v: In European Neuropsychopharmacology June 2016 26(6):994-1003

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Akademický článek

Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice

Autor: Bartłomiej Pochwat, Bernadeta Szewczyk, Katarzyna Kotarska, Anna Rafało-Ulińska, Marcin Siwiec, Joanna E. Sowa, Krzysztof Tokarski, Agata Siwek, Alexandre Bouron, Kristina Friedland, Gabriel Nowak

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained antidepressant like-activity in rodents through a molecular mechanism of action that involves the activation of Ca2+ dependent signaling pathways. Moreover, ketamine, a globa

Externí odkaz: https://doaj.org/article/fa5d759d71eb4990baf7bc6303b31729

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Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder

Autor: Keith Hawton, Rupert McShane, Claudia Hurducas, Annabelle Barnes, Styliani Spyridi, Andrea Cipriani, Tahnee Marquardt, Sarah Hollingsworth, Rebecca L Dean, Erick H. Turner, Rebecca Smith, Philip J. Cowen

Publikováno v: Cochrane Database of Systematic Reviews. 2021

Background Many studies have recently been conducted to assess the antidepressant efficacy of glutamate modification in mood disorders. This is an update of a review first published in 2015 focusing on the use of glutamate receptor modulators in unip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8decface1bbfad594402a77e352ffb2e
https://doi.org/10.1002/14651858.cd011612.pub3

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Akademický článek

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Neurophysiological and Clinical Effects of the NMDA Receptor Antagonist Lanicemine (BHV-5500) in PTSD: A Randomized, Double-Blind, Placebo-Controlled Trial

Autor: Brittany Vo-Le, Christian Grillon, Marijn Lijffijt, Charles Green, Nithya Ramakrishnan, Tabish Iqbal, Brittany O'Brien, James W. Murrough, Sanjay J. Mathew, Nicholas Murphy, Nicholas L. Balderston, Alan C. Swann

Publikováno v: Depress Anxiety

Background Posttraumatic stress disorder (PTSD) is associated with hyperarousal and stress reactivity, features consistent with behavioral sensitization. In this Phase 1b, parallel-arm, randomized, double-blind, placebo-controlled trial, we tested wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b659a95aafe94bb7f2ee4e9bdd4b2e
https://doi.org/10.2139/ssrn.3809804

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Akademický článek

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