Zobrazeno 1 - 10
of 426
pro vyhledávání: '"labile iron pool"'
Autor:
Chutvanichkul Boonyanuch, Vattanaviboon Phantip, Mas-oodi Sumana, U-pratya Yaowalak, Wanachiwanawin Wanchai
Publikováno v:
Türk Biyokimya Dergisi, Vol 49, Iss 2, Pp 178-186 (2023)
Not only do transfusion-dependent thalassemia (TDT) patients have a risk of clinical consequences arising from iron overload, non-transfusion-dependent thalassemia (NTDT) patients may encounter it also. In this study, we demonstrated the usefulness o
Externí odkaz:
https://doaj.org/article/f60bfface7204bb3ac1c059b03e50eb3
Autor:
Xueyan Wei, Yingze Li, Haotian Chen, Rui Gao, Peng Ning, Yingying Wang, Wanxin Huang, Erzhen Chen, Lan Fang, Xingrong Guo, Cheng Lv, Yu Cheng
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract Targeting ferroptosis has attracted exponential attention to eradicate cancer cells with high iron‐dependent growth. Increasing the level of intracellular labile iron pool via small molecules and iron‐containing nanomaterials is an effec
Externí odkaz:
https://doaj.org/article/c0d6bd3c6cfd46af83c012b76a9567a4
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 871 (2024)
Although the labile iron pool (LIP) biochemical identity remains a topic of debate, it serves as a universal homeostatically regulated and essential cellular iron source. The LIP plays crucial cellular roles, being the source of iron that is loaded i
Externí odkaz:
https://doaj.org/article/fe122b53f72741baba77faa491ca065f
Autor:
Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment. Methods High-throughput screening of an FDA-approved drug library was conducted to id
Externí odkaz:
https://doaj.org/article/80960a3608ac4b7ca6ff9a379051749b
Akademický článek
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Autor:
Khaliunaa Bayanbold, Mekhla Singhania, Melissa A. Fath, Charles C. Searby, Jeffrey M. Stolwijk, John B. Henrich, Casey F. Pulliam, Joshua D. Schoenfeld, Kranti A. Mapuskar, Sei Sho, Joseph M. Caster, Bryan G. Allen, Garry R. Buettner, Maria Spies, Prabhat C. Goswami, Michael S. Petronek, Douglas R. Spitz
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 2005 (2023)
The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for integration into the iron metalloproteins that are involved in diverse cellular processes, including cancer cell-specific metabolic oxidative stress. Abnormal
Externí odkaz:
https://doaj.org/article/528679c8946943c59f5691686a352e09
Akademický článek
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Akademický článek
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Autor:
Yuxue Huang, Ning Zhang, Cuiping Xie, Yayu You, Lei Guo, Feiming Ye, Xiaojie Xie, Jian’an Wang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Cardiac dysfunction is a common complication of sepsis with high mortality. The present study was designed to identify the effect of neutrophil-derived lipocalin-2 (LCN2) in septic cardiac dysfunction (SCD) and its potential mechanism. Wild-type (WT)
Externí odkaz:
https://doaj.org/article/012bd9d7280542edaa5388a62570db58
Autor:
Christian Leischner, Luigi Marongiu, Alban Piotrowsky, Heike Niessner, Sascha Venturelli, Markus Burkard, Olga Renner
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 916 (2023)
Despite the increasing number of newly diagnosed malignancies worldwide, therapeutic options for some tumor diseases are unfortunately still limited. Interestingly, preclinical but also some clinical data suggest that the administration of pharmacolo
Externí odkaz:
https://doaj.org/article/056c09e84ea54a1ba84c561177d2aa0e