Zobrazeno 1 - 10
of 358
pro vyhledávání: '"kristian helin"'
Autor:
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, Takao Yogo, Tomohiro Yabushita, Ryoji Ito, Masaya Ueno, Atsushi Hirao, Kaoru Tohyama, Chao Li, Kimihito Cojin Kawabata, Kiyoshi Yamaguchi, Yoichi Furukawa, Hidetaka Kosako, Akihide Yoshimi, Susumu Goyama, Yasuhito Nannya, Seishi Ogawa, Karl Agger, Kristian Helin, Satoshi Yamazaki, Haruhiko Koseki, Noriko Doki, Yuka Harada, Hironori Harada, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding argin
Externí odkaz:
https://doaj.org/article/d5c4ccd82b76400cb577a39dab027bde
Autor:
Helene Damhofer, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger, Daria Shlyueva, Lene Uhrbom, Gillian M. Morrison, Philip F. Hughes, Timothy Haystead, Steven M. Pollard, Kristian Helin
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-17 (2024)
Abstract Poor survival and lack of treatment response in glioblastoma (GBM) is attributed to the persistence of glioma stem cells (GSCs). To identify novel therapeutic approaches, we performed CRISPR/Cas9 knockout screens and discovered TGFβ activat
Externí odkaz:
https://doaj.org/article/9c882069fd714df8a02c424b20d4f84c
Autor:
Kevin C. L. Cheng, Jennifer M. Frost, Francisco J. Sánchez-Luque, Marta García-Canãdas, Darren Taylor, Wan R. Yang, Branavy Irayanar, Swetha Sampath, Hemalvi Patani, Karl Agger, Kristian Helin, Gabriella Ficz, Kathleen H. Burns, Adam Ewing, José L. García-Pérez, Miguel R. Branco
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling promoted by vitC improve
Externí odkaz:
https://doaj.org/article/f795feb9ee214159af694527040dae95
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0306360 (2024)
[This corrects the article DOI: 10.1371/journal.pone.0060020.].
Externí odkaz:
https://doaj.org/article/75341ed57e994a50906fdf9da19e7530
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0300623 (2024)
Regulation of protein synthesis is a key factor in hematopoietic stem cell maintenance and differentiation. Rio-kinase 2 (RIOK2) is a ribosome biogenesis factor that has recently been described an important regulator of human blood cell development.
Externí odkaz:
https://doaj.org/article/125fb3ecf203465bb974085bf2d67a7b
Autor:
Morten Tulstrup, Mette Soerensen, Jakob Werner Hansen, Linn Gillberg, Maria Needhamsen, Katja Kaastrup, Kristian Helin, Kaare Christensen, Joachim Weischenfeldt, Kirsten Grønbæk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
TET2 mutations are frequent in myeloid malignancies and in elderly individuals with or without cytopenia. Here, the authors analyse the association between TET2 mutations and methylation changes in healthy elderly twins and patients with cytopenia an
Externí odkaz:
https://doaj.org/article/4d98d81369e54a9db5a3aadacc12a62b
Autor:
Iris Müller, Ann Sophie Moroni, Daria Shlyueva, Sudeep Sahadevan, Erwin M. Schoof, Aliaksandra Radzisheuskaya, Jonas W. Højfeldt, Tülin Tatar, Richard P. Koche, Chang Huang, Kristian Helin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of
Externí odkaz:
https://doaj.org/article/9597bd4ec7404890a76dbc8df6a59f5c
Autor:
Sarah H. Kim, Arnaud Da Cruz Paula, Thais Basili, Higinio Dopeso, Rui Bi, Fresia Pareja, Edaise M. da Silva, Rodrigo Gularte-Mérida, Zhen Sun, Sho Fujisawa, Caitlin G. Smith, Lorenzo Ferrando, Ana Paula Martins Sebastião, Yonina Bykov, Anqi Li, Catarina Silveira, Charles W. Ashley, Anthe Stylianou, Pier Selenica, Wesley R. Samore, Achim A. Jungbluth, Dmitriy Zamarin, Nadeem R. Abu-Rustum, Kristian Helin, Robert A. Soslow, Jorge S. Reis-Filho, Esther Oliva, Britta Weigelt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Little is known about the genetics of sclerosing stromal tumor of the ovary, a rare type of sex cord-stromal tumor. Here, the authors use sequencing strategies to show that in a cohort of 26 tumor samples 65% carry a FHL2-GLI2 fusion gene and demonst
Externí odkaz:
https://doaj.org/article/47b2a974b2b14385a7cca2142adfd91e
Autor:
Morteza Chalabi Hajkarim, Ella Karjalainen, Mikhail Osipovitch, Konstantinos Dimopoulos, Sandra L Gordon, Francesca Ambri, Kasper Dindler Rasmussen, Kirsten Grønbæk, Kristian Helin, Krister Wennerberg, Kyoung-Jae Won
Publikováno v:
eLife, Vol 11 (2022)
Large-scale multiparameter screening has become increasingly feasible and straightforward to perform thanks to developments in technologies such as high-content microscopy and high-throughput flow cytometry. The automated toolkits for analyzing simil
Externí odkaz:
https://doaj.org/article/3f675683279247e3902e4a69cb12b59a
Autor:
Susanne Marije Kooistra, Lise Christine Rudkjær Nørgaard, Michael James Lees, Cornelia Steinhauer, Jens Vilstrup Johansen, Kristian Helin
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0272206 (2022)
[This corrects the article DOI: 10.1371/journal.pone.0091034.].
Externí odkaz:
https://doaj.org/article/9eac75daf56e476cad379522a9a8bb3c