Zobrazeno 1 - 10
of 227
pro vyhledávání: '"krishne gowda"'
Autor:
Omar S. Al-Odat, Weam Othman Elbezanti, Krishne Gowda, Sandeep K. Srivastava, Shantu G. Amin, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K. Pandey
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Despite a record number of clinical studies investigating various anti-myeloma treatments, the 5-year survival rate for multiple myeloma (MM) patients in the US is only 55%, and almost all patients relapse. Poor patient outcomes demonstrate that myel
Externí odkaz:
https://doaj.org/article/63ddb4eafebe460cae46dd670075e26e
Autor:
Kun-Ming Chen, Yuan-Wan Sun, Jiafen Hu, Karla Balogh, Krishne Gowda, Cesar Aliaga, Dongxiao Sun, Neil Christensen, Shantu Amin, Karam El-Bayoumy
Publikováno v:
ACS Omega, Vol 9, Iss 7, Pp 8434-8438 (2024)
Externí odkaz:
https://doaj.org/article/18061059da3b466ba1a6dc2a7e724b02
Publikováno v:
Pharmacological Research, Vol 203, Iss , Pp 107163- (2024)
Current cancer therapy can be effective, but the development of drug resistant disease is the usual outcome. These drugs can eliminate most of the tumor burden but often fail to eliminate the rare, “Drug Tolerant Persister” (DTP) cell subpopulati
Externí odkaz:
https://doaj.org/article/b2f9ec7bd5af44ae8b8f6a7d16184ebb
Autor:
Krishne Gowda, Asif Raza, Venugopal Vangala, Nazir Ahmad Lone, Jyh Ming Lin, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Todd D. Schell, Gavin P. Robertson, Shantu Amin, Arun K. Sharma
Publikováno v:
Molecules, Vol 29, Iss 13, p 3114 (2024)
Aldehyde dehydrogenases (ALDHs) are a family of enzymes that aid in detoxification and are overexpressed in several different malignancies. There is a correlation between increased expression of ALDH and a poor prognosis, stemness, and resistance to
Externí odkaz:
https://doaj.org/article/df10bcda0e884b7ba107ccfdd1982f9a
Autor:
Dhwani Patel, Iain A. Murray, Fangcong Dong, Andrew J. Annalora, Krishne Gowda, Denise M. Coslo, Jacek Krzeminski, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Craig B. Marcus, Andrew D. Patterson, Gary H. Perdew
Publikováno v:
Metabolites, Vol 13, Iss 9, p 985 (2023)
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that plays an important role in gastrointestinal barrier function, tumorigenesis, and is an emerging drug target. The resident microbiota is capable of metabolizing trypto
Externí odkaz:
https://doaj.org/article/eb93d6bc3a4946b3bf3803357f3aeec6
Autor:
Weam Othman Elbezanti, Omar S. Al-Odat, Robert Chitren, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Krishne Gowda, Shantu Amin, Gavin P. Robertson, Venkatesh V. Nemmara, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K. Pandey
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Despite recent improvements in multiple myeloma (MM) treatment, MM remains an incurable disease and most patients experience a relapse. The major reason for myeloma recurrence is the persistent stem cell-like population. It has been demonstrated that
Externí odkaz:
https://doaj.org/article/6aace12e025c4c0bab03f2c7841776cc
Autor:
Kun-Ming Chen, Henry Thompson, John P. Vanden-Heuvel, Yuan-Wan Sun, Neil Trushin, Cesar Aliaga, Krishne Gowda, Shantu Amin, Bruce Stanley, Andrea Manni, Karam El-Bayoumy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Docosahexaenoic acid (DHA) is known to inhibit breast cancer in the rat. Here we investigated whether DHA itself or select metabolites can account for its antitumor action. We focused on metabolites derived from the lipoxygenase (LOX) pathwa
Externí odkaz:
https://doaj.org/article/c4bb46a811624f08af671d39c0e3ef81
Autor:
Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa M. Tindall, Penny M. Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Commensal microbiota-dependent tryptophan catabolism within the gastrointestinal tract is known to exert profound effects upon host physiology, including the maintenance of epithelial barrier and immune function. A number of abundant microbiota-deriv
Externí odkaz:
https://doaj.org/article/abc1764daba54112813449492683dc6f
Autor:
Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su-Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran, Shantu Amin, David Claxton, Arati Sharma
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Leukemic stem cells are multipotent, self-renewing, highly proliferative cells that can withstand drug treatments. Although currently available treatments potentially destroy blast cells, they fail to eradicate leukemic progenitor cells completely. A
Externí odkaz:
https://doaj.org/article/9c54a0d0960441b19e406ddebb6ad8a6
Autor:
Yuan-Wan Sun, Kun-Ming Chen, Yuka Imamura Kawasawa, Anna C Salzberg, Timothy K Cooper, Carla Caruso, Cesar Aliaga, Junjia Zhu, Krishne Gowda, Shantu Amin, Karam El-Bayoumy
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186873 (2017)
Genetic and epigenetic alterations observed at end stage OSCC formation could be considered as a consequence of cancer development and thus changes in normal or premalignant tissues which had been exposed to oral carcinogens such as Dibenzo[def,p]chr
Externí odkaz:
https://doaj.org/article/12b846c2487748eca9e57fcc286c5aab