Zobrazeno 1 - 10
of 827
pro vyhledávání: '"knockouts"'
Autor:
Qian Chen, Minhui Pang, Peng Chen, Zihao Zhou, Jun Lei, Boxiao He, Zaiqiao Sun, Chonil Paek, Baowei Jing, Yankang Wu, Shiqi Liu, Yongshun Chen, Lei Yin
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Abstract CRISPR/Cas12a‐based combinational screening has shown remarkable potential for identifying genetic interactions. Here, we describe an innovative method for combinational genetic screening with rapid construction of a dual‐CRISPR RNA (crR
Externí odkaz:
https://doaj.org/article/ef996bcaf008462485874f22f8c6ad37
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
In rodents, oxytocin (Oxt) contributes to the onset of maternal care by shifting the perception of pups from aversive to attractive. Both Oxt receptor knockout (Oxtr −/−) and forebrain-specific Oxtr knockout (FB/FB) dams abandon their first litte
Externí odkaz:
https://doaj.org/article/929989d66f4c4209a42f848130843940
Autor:
Handley, Caleb James
Publikováno v:
Journal of Australian Strength & Conditioning; 2023, Vol. 31 Issue 7, p39-45, 7p
Autor:
Rachel H. Klein, Paul S. Knoepfler
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-8 (2023)
Abstract Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease. Here we discuss how gene targeting studies of the two H3.3-coding genes
Externí odkaz:
https://doaj.org/article/888b56556cad4593818e4d840c8bab5c
Autor:
ROGERS, KATE, NIEHOFF, LEN
Publikováno v:
Litigation. Fall2023, Vol. 50 Issue 1, p30-34. 5p. 1 Color Photograph.
Autor:
Aziz Belkadi, Gaurav Thareja, Fatemeh Abbaszadeh, Ramin Badii, Eric Fauman, Omar M.E. Albagha, Karsten Suhre
Publikováno v:
Cell Genomics, Vol 3, Iss 1, Pp 100218- (2023)
Summary: Natural human knockouts of genes associated with desirable outcomes, such as PCSK9 with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and treatments. Rare loss-of-function variants are more likely to be found i
Externí odkaz:
https://doaj.org/article/e1770f153d584d008d88b05b5bb7250b
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 34, Iss 12, Pp 1336-1345 (2021)
The development of knockout mutants and expression variants are critical for understanding genotype-phenotype relationships. However, advances in these techniques in gram-positive actinobacteria have stagnated over the last decade. Actinobacteria in
Externí odkaz:
https://doaj.org/article/8f1f1686fc634fc6bcd734d08f97d758
Publikováno v:
Russian Life. Jan/Feb2022, Vol. 65 Issue 1, p10-10. 1/4p.
Akademický článek
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Autor:
Sudhanshu Saxena, Satyendra Gautam
Publikováno v:
Heliyon, Vol 8, Iss 7, Pp e09945- (2022)
Natural dietary products of health promoting and disease preventive functional relevance are gaining significant prominence. Current investigation was aimed to decipher the underlying molecular mechanism responsible for the antimutagenic action contr
Externí odkaz:
https://doaj.org/article/4a55675812ff4ae8ba73626ad075c8b1