Zobrazeno 1 - 10
of 2 006
pro vyhledávání: '"knockin"'
Autor:
C. Quadalti, M. Sannia, N.E. Humphreys, V.A. Baldassarro, A. Gurgone, M. Ascolani, L. Zanella, L. Giardino, C.T. Gross, S. Croci, I. Meloni, M. Giustetto, A. Renieri, L. Lorenzini, L. Calzà
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e40165- (2024)
CDKL5 deficiency disorder (CDD) is a rare neurodevelopmental syndrome caused by mutations in the X-linked CDKL5 gene. Hundreds of pathogenic variants have been described, associated with a significant phenotypic heterogeneity observed among patients.
Externí odkaz:
https://doaj.org/article/56ddabb048be41ef958959507b9fd035
Publikováno v:
Liver Research, Vol 8, Iss 2, Pp 91-104 (2024)
Background and aim: Glucocorticoids are the only first-line drugs for severe alcoholic hepatitis (AH), with limited efficacy and various side effects on extrahepatic tissues. Liver-targeting glucocorticoid therapy may have multiple advantages over sy
Externí odkaz:
https://doaj.org/article/2f4ffd68fe0a463ebdb13b2e1ef5ec6d
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1687-1698 (2024)
The Gt(ROSA)26Sor (ROSA26) and H11 loci are commonly used as safe harbors for the construction of targeted transgenic mice. However, it remains unclear whether these two loci have distinct effects on transgene expression. In this study, we insert thr
Externí odkaz:
https://doaj.org/article/1701b06e25594f5d9393c647733bc2f1
Autor:
Kyung Soo Kang, Seung Pyo Shin, In Su Ha, Si Eun Kim, Ki Hyun Kim, Hyeong Ju Ryu, Tae Sub Park
Publikováno v:
Animal Bioscience, Vol 36, Iss 6, Pp 973-979 (2023)
Objective The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system, which is the most efficient and reliable tool for precisely targeted modification of the genome of living cells, has generated
Externí odkaz:
https://doaj.org/article/98f56508125749debaf2a5f4953733e4
Autor:
Jeong Hyeon Lee, Jeong Pil Han, Dong Woo Song, Geon Seong Lee, Beom Seok Choi, MinJeong Kim, Yeji Lee, Seokjoong Kim, Hyukjin Lee, Su Cheong Yeom
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 161-172 (2023)
Recent therapeutic strategies for hemophilia include long-term therapeutic gene expression using adeno-associated virus (AAV) and rebalancing therapy via the downregulation of anticoagulant pathways. However, these approaches have limitations in immu
Externí odkaz:
https://doaj.org/article/b2eacd899eaa49578e6f6dbdd78f0144
Publikováno v:
SLAS Discovery, Vol 28, Iss 3, Pp 88-94 (2023)
Deficiencies in brain-derived neurotrophic factor (BDNF) have been linked to several brain disorders, making compounds that can boost neuronal BDNF synthesis attractive as potential therapeutics. However, a sensitive and quantitative BDNF assay for h
Externí odkaz:
https://doaj.org/article/43336eeec251408d93ed97f14568976f
Autor:
Séverine Ménoret, Laurent Tesson, Séverine Remy, Victor Gourain, Céline Sérazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Hélène Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Regulatory T cells (Treg) in diverse species include CD4+ and CD8+ T cells. In all species, CD8+ Treg have been only partially characterized and there is no rat model in which CD4+ and CD8+ FOXP3+ Treg are genetically tagged. Resu
Externí odkaz:
https://doaj.org/article/a5f7fd4d1ec14f8a9408162e7c0a4594
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