Zobrazeno 1 - 10
of 1 230
pro vyhledávání: '"knock down"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Chromodomain helicase DNA-binding protein (CHD) gene family, an ATP (adenosine triphosphate) -dependent chromatin remodeler family, is involved in multiple developmental process and tumor development. However, there have been none pan-cancer
Externí odkaz:
https://doaj.org/article/421a03467c9e4b5c98a5a6ae6cb63494
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 6, Pp 821-827 (2024)
Objective To explore the design of CRISPR interference (CRISPRi) tools based on the deactivated CasMINI (dCasMINI) protein and to evaluate their transcriptional inhibition effects. Methods The tetracycline-on (tet-on) system, flow cytometry, and quan
Externí odkaz:
https://doaj.org/article/c618e3ee9e5f456a8a160ea9982173c3
Autor:
Al-Eidan, Ahood 1, 2, Draper, Ben 1, Wang, Siyuan 1, Coke, Brandon 1, Skipp, Paul 1, Wang, Yihua 1, Ewing, Rob M. 1, ∗
Publikováno v:
In Molecular & Cellular Proteomics December 2024 23(12)
Autor:
Naomi Krochmal, Shana
Publikováno v:
Entertainment Weekly. 4/19/2019, Issue 1558/1559, p34-37. 4p. 3 Color Photographs.
Autor:
Vijay Singh, Marissa A. Menard, Geidy E. Serrano, Thomas G. Beach, Hien T. Zhao, Alexis Riley-DiPaolo, Nitya Subrahmanian, Matthew J. LaVoie, Laura A. Volpicelli-Daley
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Autosomal dominant pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). The most common mutation, G2019S-LRRK2, increases the kinase activity of LRRK2 causing hyper-phosphorylation of its substrates.
Externí odkaz:
https://doaj.org/article/32aba7e8d1c24bdfa405421b9f329790
Autor:
Patrick Neckermann, Madlen Mohr, Martina Billmeier, Alexander Karlas, Ditte R. Boilesen, Christian Thirion, Peter J. Holst, Ingo Jordan, Volker Sandig, Benedikt Asbach, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Modified vaccinia virus Ankara is a versatile vaccine vector, well suited for transgene delivery, with an excellent safety profile. However, certain transgenes render recombinant MVA (rMVA) genetically unstable, leading to the accumulation of mutated
Externí odkaz:
https://doaj.org/article/04652d8cafeb4982bcb8ca46679fd314
Autor:
Thomas Merckx, Matthew E. Nielsen, Tuomas Kankaanpää, Tomáš Kadlec, Mahtab Yazdanian, Sami M. Kivelä
Publikováno v:
Evolutionary Applications, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract Urbanization and its urban‐heat‐island effect (UHI) have expanding footprints worldwide. The UHI means that urban habitats experience a higher mean and more frequent extreme high temperatures than rural habitats, impacting the ontogeny a
Externí odkaz:
https://doaj.org/article/1f1160c00dec418a80b8ce872c16c064
Autor:
Baptiste Broc, Karine Varini, Rose Sonnette, Belinda Pecqueux, Florian Benoist, Maxime Masse, Yasmine Mechioukhi, Géraldine Ferracci, Jamal Temsamani, Michel Khrestchatisky, Guillaume Jacquot, Pascaline Lécorché
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 548 (2024)
Small RNA molecules such as microRNA and small interfering RNA (siRNA) have become promising therapeutic agents because of their specificity and their potential to modulate gene expression. Any gene of interest can be potentially up- or down-regulate
Externí odkaz:
https://doaj.org/article/d18b782c114946fb96922673ea48d736
Autor:
GUTHRIE, MARISA
Publikováno v:
Hollywood Reporter. 1/24/2019, Vol. 425 Issue 4, p58-64. 7p. 7 Color Photographs, 1 Graph.