Zobrazeno 1 - 10
of 5 025
pro vyhledávání: '"klf4"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Ovarian cancer (OC) is a highly fatal gynecological malignancy worldwide, and cisplatin (CDDP) is commonly used as an initial chemotherapy treatment for OC. Nonetheless, most patients ultimately face recurrence because of resistance to cispl
Externí odkaz:
https://doaj.org/article/0fb133473eff4ae087d3197de570032c
Autor:
Yiling Tan, Jiayu Wang, Chunming Liu, Shujuan Wu, Mengqi Zhou, Yan Zhang, Tailang Yin, Jing Yang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-25 (2024)
Abstract Background Recurrent spontaneous abortion (RSA) is defined as two or more consecutive spontaneous abortions before 20 weeks with the same spouse [1]. However, approximately 50% of RSA cases of unknown cause are classified as unexplained recu
Externí odkaz:
https://doaj.org/article/8a4371aa654d440eba28344d96659a75
Autor:
Feng Peng, Ruizhi He, Yuhui Liu, Yu Xie, Guangbing Xiong, Xu Li, Min Wang, Chunle Zhao, Hang Zhang, Simiao Xu, Renyi Qin
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 4, Pp 1098-1110 (2024)
Cholangiocarcinoma is one of the most lethal human cancers, and chemotherapy failure is a major cause of recurrence and poor prognosis. We previously demonstrated that miR-200 family members are downregulated in clinical samples of cholangiocarcinoma
Externí odkaz:
https://doaj.org/article/51344991e4124770945624e795c76798
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Uveal melanoma (UM), the most common adult intraocular tumor, is characterized by high malignancy and poor prognosis in advanced stages. Angiogenesis is critical for UM development, however, not only the role of vascular endotheli
Externí odkaz:
https://doaj.org/article/812d671e88f246449f67b327ad7b4c1b
Autor:
Nada Bejar, Siyu Xiao, Dinakar Iyer, Azeez Muili, Adeniyi Adeleye, Bradley K. McConnell, Robert J. Schwartz
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
This review outlines some of the many approaches taken over a decade or more to repair damaged hearts. We showcase the recent breakthroughs in organ regeneration elicited by reprogramming factors OCT3/4, SOX2, KLF4, and C-MYC (OKSM). Transient OKSM t
Externí odkaz:
https://doaj.org/article/4f5bb103593a43339ba38eaeff29eaa1
Autor:
Xue Xiao, Tingting Tang, Mingxia Bi, Jing Liu, Mengru Liu, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103322- (2024)
In Parkinson's disease (PD), exogenous ghrelin protects dopaminergic neurons through its receptor, growth hormone secretagogue receptor (GHSR). However, in contrast to the strikingly low levels of ghrelin, GHSR is highly expressed in the substantia n
Externí odkaz:
https://doaj.org/article/2f44f475dd6342e89790dfdab2a72279
Autor:
Yang Ma, Yanfang Zhang, Fangfang Chen, Sihua Liu, Dongdong Wang, Zheng Lu, Dengyong Zhang, Rui Liang
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37361- (2024)
Background: The role and molecular mechanisms of collagen type VII (COL7A1) in cholangiocarcinoma (CCA) remain unknown. Methods: We analyzed the expression of COL7A1 in CCA and its relationship with patient prognosis using bioinformatic techniques. E
Externí odkaz:
https://doaj.org/article/f2a2887ffe364514b9d57f40d22ae8bb
Autor:
Yidan Liang, Jiamin Zhao, Tengkun Dai, Xin Li, Longqin Chen, Zhixu He, Mengmeng Guo, Juanjuan Zhao, Lin Xu
Publikováno v:
Pharmacological Research, Vol 207, Iss , Pp 107345- (2024)
Inflammation is the response of the human body to injury, infection, or other abnormal states, which is involved in the development of many diseases. As a member of the Krüppel-like transcription factors (KLFs) family, KLF4 plays a crucial regulator
Externí odkaz:
https://doaj.org/article/ecf3f73fe28142b4bd8d14056c483a9f
Publikováno v:
ESC Heart Failure, Vol 11, Iss 2, Pp 1009-1021 (2024)
Abstract Aims Myocardial ischaemia–reperfusion injury (MIRI) contributes to serious myocardial injury and even death. Long non‐coding RNAs (lncRNAs) have been reported to play pivotal roles in the occurrence and development of MIRI. Here, the det
Externí odkaz:
https://doaj.org/article/6150af52c44249bf9b2dac175d98b83d
Autor:
Peng Cheng, Xudong Xie, Liangcong Hu, Wu Zhou, Bobin Mi, Yuan Xiong, Hang Xue, Kunyu Zhang, Yuxiao Zhang, Yiqiang Hu, Lang Chen, Kangkang Zha, Bin Lv, Ze Lin, Chuanlu Lin, Guandong Dai, Yixin Hu, Tengbo Yu, Hankun Hu, Guohui Liu, Yingze Zhang
Publikováno v:
Bioactive Materials, Vol 33, Iss , Pp 157-173 (2024)
It is imperative to develop and implement newer, more effective strategies to address refractory diabetic wounds. As of now, there is currently no optimal solution for these wounds. Hypoxic human umbilical vein endothelial cells (HUVECs)-derived exos
Externí odkaz:
https://doaj.org/article/0709a3d1a9a94507a6eec28f88c67afd