Zobrazeno 1 - 10
of 259
pro vyhledávání: '"kirsten rat sarcoma viral oncogene homolog"'
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 5, Pp 1027-1038 (2023)
Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) is now a drugable oncogenic driver and the KRAS G12C variant responds clinically to sotorasib and adagrasib that covalently block the cysteine of the active center and inhibit downstream signal
Externí odkaz:
https://doaj.org/article/3974f7c0caac49f9930c0d8b323ee4cc
Autor:
Ibnu Purwanto, Benedreky Leo, Bambang Purwanto Utomo, Imam Sofii, Ery Kus Dwianingsih, Neneng Ratnasari
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 818-826 (2023)
Most cases of colorectal cancer develop from adenomatous polyps, slowly progressing within an average period of 8–10 years. McKittrick-Wheelock syndrome (MKWS) is a rare manifestation of tubulovillous adenoma. It generally presents as hypersecretor
Externí odkaz:
https://doaj.org/article/805be2ba0f024a5b8bb0914fca1e9fae
Publikováno v:
National Journal of Laboratory Medicine, Vol 12, Iss 3, Pp PO01-PO04 (2023)
Introduction: Lung cancer is the second most common cancer diagnosed in the world. According to GLOBOCAN 2020, it is approximately 11.4% of all malignancies and accounts for one in five cancer deaths worldwide. Several driver gene mutations are known
Externí odkaz:
https://doaj.org/article/87b9d5dfd37b40c8974d0c763dc3b26a
Autor:
Maryam Alavi, Ana Mejia-Bautista, Meiyi Tang, Jela Bandovic, Avi Z. Rosenberg, Agnieszka B. Bialkowska
Publikováno v:
Cancers, Vol 15, Iss 22, p 5427 (2023)
Chronic pancreatitis results in the formation of pancreatic intraepithelial neoplasia (PanIN) and poses a risk of developing pancreatic cancer. Our previous study demonstrated that Krüppel-like factor 5 (KLF5) is necessary for forming acinar-to-duct
Externí odkaz:
https://doaj.org/article/ac149c229fa14bfba31da7e1f347ff63
Publikováno v:
Asian Pacific Journal of Cancer Biology, Vol 7, Iss 2, Pp 125-132 (2022)
Background: Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (K-RAS) are the most common driver genes in patients with non-small cell lung cancer adenocarcinomas (NSCLC/ADC), which affects treatment. Therefore, t
Externí odkaz:
https://doaj.org/article/406ef34d755c4470a1b52e3dab364ed6
Autor:
Afia Muhammad Akram, Asma Chaudhary, Humera Kausar, Fayez Althobaiti, Afshan Syed Abbas, Zawar Hussain, Naz Fatima, Erum Zafar, Wajiha Asif, Umair Afzal, Zoufishan Yousaf, Amjad Zafar, Steve M. Harakeh, Samina Qamer
Publikováno v:
Saudi Journal of Biological Sciences, Vol 28, Iss 7, Pp 3735-3740 (2021)
Rat sarcoma gene (RAS) holds great importance in pathogenesis of acute myeloid leukemia (AML). The activated mutations in Neuroblastoma rat sarcoma viral oncogene homolog (NRAS) and Kirsten rat sarcoma viral oncogene homolog (KRAS) confers proliferat
Externí odkaz:
https://doaj.org/article/4a78de6c9bac453c832a72f61342ed65
Autor:
Qunli Xiong, Zhu Zeng, Yang Yang, Ya Wang, Yongfeng Xu, Ying Zhou, Jinlu Liu, Zhiwei Zhang, Meng Qiu, Qing Zhu
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundClose to one third of colorectal cancer (CRC) patients are diagnosed with metastatic CRC (mCRC). Patients with wild-type RAS and BRAF usually receive anti-EGFR monoclonal antibody therapy containing cetuximab. Overall, 30–50% of mCRC pati
Externí odkaz:
https://doaj.org/article/5f0e8a615d214e049c3377f6b36c00e7
Publikováno v:
Journal of Medical Sciences, Vol 40, Iss 6, Pp 257-264 (2020)
Background: Analysis of O6-methylguanine DNA methyltransferase (MGMT) methylation considers as a predictive marker for chemotherapy sensitivity. Mutation in BRAF and Kirsten RAt sarcoma viral oncogene homolog (KRAS) gene is also crucial in colorectal
Externí odkaz:
https://doaj.org/article/6e5e99061c2742969bd8f638a68b24fb
Akademický článek
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Publikováno v:
Biomedicine & Pharmacotherapy, Vol 132, Iss , Pp 110807- (2020)
Colorectal cancer (CRC) is a stem cell-based disease. PIK3CA/KRAS-mutant CRC stem cells (CRCSCs) display high self-renewal, metastatic properties, high activity of PI3K and KRAS signaling pathways with chemoresistant phenotypes. Recently, RGD peptide
Externí odkaz:
https://doaj.org/article/ac752115c62b4fca9a81b5b8c387ebd1