Zobrazeno 1 - 10
of 2 651
pro vyhledávání: '"kinome"'
Autor:
Daniel J. Smit, Konstantin Hoffer, Bettina Bettin, Malte Kriegs, Laure Cayrefourcq, Udo Schumacher, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker
Publikováno v:
Cancer Medicine, Vol 13, Iss 20, Pp n/a-n/a (2024)
ABSTRACT Background Research on circulating tumor cells (CTCs) offers the opportunity to better understand the initial steps of blood‐borne metastasis as main cause of cancer‐related deaths. Here, we have used the colon cancer CTC‐MCC‐41 and
Externí odkaz:
https://doaj.org/article/01c855f9ce71411bbeb5e216d4700d46
Publikováno v:
Biochemistry and Biophysics Reports, Vol 40, Iss , Pp 101864- (2024)
The TGF-β signaling pathway is closely associated with human health and disease, and the systematic identification of factors involved in the TGF-β signaling pathway significantly contributes to the understanding and treatment of various diseases.
Externí odkaz:
https://doaj.org/article/aecbb43694934f1ab4f7ac48b6dfb829
Autor:
Jasmin Bazant, Astrid Weiss, Julia Baldauf, Ralph Theo Schermuly, Torsten Hain, Rudolf Lucas, Mobarak Abu Mraheil
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionProtein kinases are indispensable reversible molecular switches that adapt and control protein functions during cellular processes requiring rapid responses to internal and external events. Bacterial infections can affect kinase-mediated
Externí odkaz:
https://doaj.org/article/b2880ece0d214429bbeacad67248d591
Autor:
Marziyeh Salehi Jahromi, Kathryn B. Smedlund, William G. Ryan, Ali Sajjad Imami, Robert E. Smith, Jennifer W. Hill
Publikováno v:
Translation, Vol 12, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/2db6fa8beb6444fdb94bc7da2d26a89b
Publikováno v:
Translation, Vol 12, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/8b262bafb8e64dd9976dc0d70cdd750e
Autor:
Viviana Vella, Angeliki Ditsiou, Anna Chalari, Murat Eravci, Sarah K. Wooller, Teresa Gagliano, Cecilia Bani, Emanuela Kerschbamer, Christos Karakostas, Bin Xu, Yongchang Zhang, Frances M.G. Pearl, Gianluca Lopez, Ling Peng, Justin Stebbing, Apostolos Klinakis, Georgios Giamas
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Temozolomide (TMZ) represents the cornerstone of therapy for glioblastoma (GBM). However, acquisition of resistance limits its therapeutic potential. The human kinome is an undisputable source of druggable targets, still, current knowledge r
Externí odkaz:
https://doaj.org/article/10bdea1081e24054b2aa80185b300ab8
Autor:
Isaac Filella-Merce, Vincent Mallet, Eric Durand, Michael Nilges, Guillaume Bouvier, Riccardo Pellarin
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
The current richness of sequence data needs efficient methodologies to display and analyze the complexity of the information in a compact and readable manner. Traditionally, phylogenetic trees and sequence similarity networks have been used to displa
Externí odkaz:
https://doaj.org/article/0384b44ff500435caecb9c3e1a275366
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Protein kinases play vital roles in controlling cell behavior, and an array of kinase inhibitors are used successfully for treatment of disease. Typical drug development pipelines involve biological studies to validate a protein kinase target, follow
Externí odkaz:
https://doaj.org/article/124b586eaa204c3bb1d5f9d07ef06380
Publikováno v:
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 26, Pp 0-0 (2024)
Background and Objective: Kinome refers to the complete set of protein kinases encoded in the genome. The most common type of post-translational modification is phosphorylation, with more than two-thirds of all human encoded proteins being phosphoryl
Externí odkaz:
https://doaj.org/article/70cd6d10ca6d4067894f00996ee77945
Publikováno v:
PeerJ, Vol 11, p e16164 (2023)
Background Aberrant protein kinase regulation leading to abnormal substrate phosphorylation is associated with several human diseases. Despite the promise of therapies targeting kinases, many human kinases remain understudied. Most existing computati
Externí odkaz:
https://doaj.org/article/7f22cfd4ac3b4f05b4ac87e17b564fd2