Zobrazeno 1 - 10
of 1 883
pro vyhledávání: '"kinase inhibition"'
Autor:
Ala I. Sharara, Ayman Alrazim, Philippe Saniour, Fady Daniel, Antoine Abou Rached, Abbas Bahr, Cecilio Azar, Antoine Geagea, Marcelle Ghoubar
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Objective To evaluate the effectiveness and safety of tofacitinib in patients with ulcerative colitis (UC) in clinical practice in Lebanon. Design This was a retrospective cross-sectional study. The data were collected from hospital records.
Externí odkaz:
https://doaj.org/article/cd991cf0fcfa48ac8217daed4515d6fe
Autor:
Ghassan K. Abou-Alfa, Tim Meyer, Richard Kinh Gian Do, Sarina A. Piha-Paul, Joseph S. Light, Scott Sherrin, Amin Yaqubie, Alison Clemens O’Neill, James J. Harding, Raed Al-Rajabi, Crystal S. Denlinger, Pablo Cano, Albert S. Cornelius, Eileen M. O'Reilly, Daniel DiPrimeo, Lisa D. Eli, John D. Gordan, David B. Solit
Publikováno v:
Liver Cancer, Pp 1-10 (2024)
Introduction: Fibrolamellar carcinoma (FLC) displays upregulation of several oncogenes, including HER2, and multiple immune-suppressive mechanisms. We investigated the efficacy and safety of the pan-HER tyrosine kinase inhibitor neratinib as monother
Externí odkaz:
https://doaj.org/article/060277f2d7054affa161c9c60698ca95
Autor:
Eric L. Simpson, Leon Kircik, Andrew Blauvelt, Howard Kallender, Daniel Sturm, Mingyue Wang, Lawrence F. Eichenfield
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 8, Pp 2139-2151 (2024)
Abstract Introduction Standard therapy for patients with mild to moderate atopic dermatitis (AD) typically includes topical therapies; however, patients with more extensive AD and/or AD refractory to topical therapy may benefit from systemic treatmen
Externí odkaz:
https://doaj.org/article/2fa3e6b985ae41b8b3c724659680482a
Publikováno v:
Phycology, Vol 4, Iss 2, Pp 213-234 (2024)
Core chlorophytes possess glycerol-3-phosphate dehydrogenases (GPDs) with an unusual bidomain structure, consisting of a glycerol-3-phosphate phosphatase (GPP) domain fused to canonical GPD domains. These plastid-localized enzymes have been implicate
Externí odkaz:
https://doaj.org/article/30d6612d8f374c26b721193ba8187f5c
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/9f892f09951c481bbf42b629bcadeb3e
Publikováno v:
BMC Urology, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Checkpoint inhibitor immunotherapy plus tyrosine kinase inhibitor (IO/TKI) have been recently recommended as standard first-line therapy for advanced renal cell carcinoma, while no clinical-available biomarker has been applied. Th
Externí odkaz:
https://doaj.org/article/9544146360e845d59aaccdc82888b131
Autor:
Nathan Broudic, Alexandra Pacheco-Benichou, Cécile Corbière, Blandine Baratte, Thomas Robert, Stéphane Bach, Hélène Solhi, Rémy Le Guével, Corinne Fruit, Thierry Besson
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1452 (2024)
Background/Objectives: In connection with previous work on V-shaped polycyclic thiazolo[5,4-f]quinazolin-9-one and [5,4-f]quinazoline derivatives that can modulate the activity of various kinases, the synthesis of straight thiazole-fused [4,5-g] or [
Externí odkaz:
https://doaj.org/article/9fca41b7c93b4c3b930e5e47bdadcea3
Autor:
Najib Ben Khaled, Marie Möller, Leonie S. Jochheim, Catherine Leyh, Ursula Ehmer, Katrin Böttcher, Matthias Pinter, Lorenz Balcar, Bernhard Scheiner, Alexander Weich, Hans Benno Leicht, Valentina Zarka, Liangtao Ye, Julia Schneider, Ignazio Piseddu, Osman Öcal, Monika Rau, Friedrich Sinner, Marino Venerito, Simon Johannes Gairing, Friedrich Förster, Julia Mayerle, Enrico N. De Toni, Andreas Geier, Florian P. Reiter
Publikováno v:
JHEP Reports, Vol 6, Iss 6, Pp 101065- (2024)
Background & Aims: Atezolizumab/bevacizumab (atezo/bev) and lenvatinib have demonstrated efficacy as first-line therapies for hepatocellular carcinoma (HCC). However, vascular endothelial growth factor (VEGF) inhibition with these therapies may be as
Externí odkaz:
https://doaj.org/article/8bfa5b4342fd47ce9b2a38f731714629
Autor:
Ioanna Liatsou, Betelhem Assefa, Wathsala Liyanage, Sharmane Surasinghe, Zora Nováková, Cyril Bařinka, Kathleen Gabrielson, Venu Raman, Dmitri Artemov, Sudath Hapuarachchige
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Prostate cancer (PC) is an aggressive cancer that can progress rapidly and eventually become castrate-resistant prostate cancer (CRPC). Stage IV metastatic castrate-resistant prostate cancer (mCRPC) is an incurable late-stage cancer type with a low 5
Externí odkaz:
https://doaj.org/article/e55e46e0874d464dbbedcee553133c11
Anticancer properties and mechanism of action of the fungal nucleoside clitocine and its derivatives
Autor:
Christian Bailly
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 10, Iss , Pp 100123- (2024)
Clitocine (CLT) is an atypical nitro-containing pyrimidine nucleoside bearing a ribofuranosyl moiety attached to the exocyclic 4-amino position. It has been isolated first from the fungus Clitocybe inversa and then from fruiting bodies of Leucopaxill
Externí odkaz:
https://doaj.org/article/14201cbeccb64d2d9f50285a36d6c2b5