Zobrazeno 1 - 10
of 706
pro vyhledávání: '"kinase assay"'
Autor:
Analia G. Novero, Catalina Curcio, Tomás J. Steeman, Andres Binolfi, Diego Krapf, Mariano G. Buffone, Dario Krapf, Cintia Stival
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The cAMP-dependent protein kinase (PKA) is one of the most extensively distributed kinases among intracellular signal cascades, with a pivotal role in the regulation of various processes, including the capacitation of sperm cells. Traditional assessm
Externí odkaz:
https://doaj.org/article/c6f8f492d1dc4b82915273e5633269f8
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-18 (2022)
Abstract Background A significant fraction of the human proteome is still inaccessible to in vitro studies since the recombinant production of several proteins failed in conventional cell factories. Eukaryotic protein kinases are difficult-to-express
Externí odkaz:
https://doaj.org/article/81c57a9f01144251bf7bb7a29ffc4857
Akademický článek
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Autor:
Zehan Hu, Devanarayanan Siva Sankar, Bich Vu, Alexandre Leytens, Christine Vionnet, Wenxian Wu, Michael Stumpe, Esther Martínez-Martínez, Björn Stork, Jörn Dengjel
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109762- (2021)
Summary: The evolutionarily conserved ULK1 kinase complex acts as gatekeeper of canonical autophagy and regulates induction of autophagosome biogenesis. To better understand control of ULK1 and analyze whether ULK1 has broader functions that are also
Externí odkaz:
https://doaj.org/article/faaa8cfccbad479e94050be695b0f084
Autor:
Gema González-Rubio, Lucía Sastre-Vergara, María Molina, Humberto Martín, Teresa Fernández-Acero
Publikováno v:
Journal of Fungi, Vol 8, Iss 4, p 368 (2022)
The cell wall integrity (CWI) MAPK pathway of budding yeast Saccharomyces cerevisiae is specialized in responding to cell wall damage, but ongoing research shows that it participates in many other stressful conditions, suggesting that it has function
Externí odkaz:
https://doaj.org/article/ea57096b24d04e288ca809371e8b4831
Akademický článek
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Autor:
Mariateresa Di Stazio, Stefania Bigoni, Nicola Iuso, Josef Vuch, Rita Selvatici, Sheila Ulivi, Pio Adamo d’Adamo
Publikováno v:
Brain Sciences, Vol 11, Iss 8, p 1105 (2021)
Background: Coffin–Lowry syndrome (CLS) is a syndromic form of X-linked intellectual disability, in which specific associated facial, hand, and skeletal abnormalities are diagnostic features. Methods: In the present study, an unreported missense ge
Externí odkaz:
https://doaj.org/article/1ab9071628f445a29991fbb01a1d7617
Autor:
Philipp Mertins, Dariusz Przybylski, Nir Yosef, Jana Qiao, Karl Clauser, Raktima Raychowdhury, Thomas M. Eisenhaure, Tanja Maritzen, Volker Haucke, Takashi Satoh, Shizuo Akira, Steven A. Carr, Aviv Regev, Nir Hacohen, Nicolas Chevrier
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2853-2866 (2017)
Building an integrated view of cellular responses to environmental cues remains a fundamental challenge due to the complexity of intracellular networks in mammalian cells. Here, we introduce an integrative biochemical and genetic framework to dissect
Externí odkaz:
https://doaj.org/article/78b5c7901c5847ab990bbd7395c9f727
Akademický článek
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Autor:
Thitinan Aiebchun, Panupong Mahalapbutr, Atima Auepattanapong, Onnicha Khaikate, Supaphorn Seetaha, Lueacha Tabtimmai, Chutima Kuhakarn, Kiattawee Choowongkomon, Thanyada Rungrotmongkol
Publikováno v:
Molecules, Vol 26, Iss 8, p 2211 (2021)
Epidermal growth factor receptor (EGFR), overexpressed in many types of cancer, has been proved as a high potential target for targeted cancer therapy due to its role in regulating proliferation and survival of cancer cells. In the present study, a s
Externí odkaz:
https://doaj.org/article/0755dedd19234c8d988d7cd22d8db2a8