Zobrazeno 1 - 10
of 1 714
pro vyhledávání: '"kidney fibrosis"'
Autor:
Kaiqiang Zhao, Zhongjun Zhou
Publikováno v:
eLife, Vol 13 (2024)
The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.
Externí odkaz:
https://doaj.org/article/087377f589324058a23766afc418d3d4
Autor:
Jun Liu, Bo Zheng, Qingya Cui, Yu Zhu, Likai Chu, Zhi Geng, Yiming Mao, Lin Wan, Xu Cao, Qianwei Xiong, Fujia Guo, David C Yang, Ssu‐Wei Hsu, Ching‐Hsien Chen, Xiangming Yan
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract With the increasing incidence of kidney diseases, there is an urgent need to develop therapeutic strategies to combat post‐injury fibrosis. Immune cells, including platelets, play a pivotal role in this repair process, primarily through th
Externí odkaz:
https://doaj.org/article/169b9221f5c349fc9c0bccd85efae23c
Autor:
Qian Zhao, Jiale Dong, Han Liu, Hui Chen, Huan Yu, Shuyin Ye, Shuangjin Yu, Yu Li, Longhui Qiu, Nazi Song, Hongjiao Xu, Qi Liu, Zhiteng Luo, Yuyi Li, Rui Wang, Guodong Chen, Xianxing Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1283-1301 (2024)
The role of co-agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in chronic kidney disease (CKD) remains unclear. Herein we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compa
Externí odkaz:
https://doaj.org/article/aea8bd1cc5cd42f4ac94f66dabd72a9d
Identification of common and specific fibrosis-related genes in three common chronic kidney diseases
Autor:
Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Background Kidney fibrosis is the common final pathway of virtually all advanced forms of chronic kidney disease (CKD) including diabetic nephropathy (DN), IgA nephropathy (IgAN) and membranous nephropathy (MN), with complex mechanism. Comparative ge
Externí odkaz:
https://doaj.org/article/b74ca09f5ab84dfe9396f48b6664a705
Autor:
Xinrong Hu, Lu Gan, Ziwen Tang, Ruoni Lin, Zhou Liang, Feng Li, Changjian Zhu, Xu Han, Ruilin Zheng, Jiani Shen, Jing Yu, Ning Luo, Wenxing Peng, Jiaqing Tan, Xiaoyan Li, Jinjin Fan, Qiong Wen, Xin Wang, Jianbo Li, Xunhua Zheng, Qinghua Liu, Jianping Guo, Guo‐Ping Shi, Haiping Mao, Wei Chen, Sheng Yin, Yi Zhou
Publikováno v:
Advanced Science, Vol 11, Iss 13, Pp n/a-n/a (2024)
Abstract Kidney fibrosis is a common fate of chronic kidney diseases (CKDs), eventually leading to renal dysfunction. Yet, no effective treatment for this pathological process has been achieved. During the bioassay‐guided chemical investigation of
Externí odkaz:
https://doaj.org/article/054a6dfa8a9f4409ad41f1fd3edfd7f9
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116144- (2024)
Mitochondrial dysfunction is one of the key mechanisms for developing chronic kidney disease (CKD). Hyperoxaluria and nephrolithiasis are also associated with mitochondrial dysfunction. Increasing evidence has shown that caffeine, the main bioactive
Externí odkaz:
https://doaj.org/article/2ec54df6c7234432815634fa90d98e41
Autor:
Carlos Menendez-Castro, Nada Cordasic, Fabian B. Fahlbusch, Joachim Woelfle, Karl F. Hilgers, Andrea Hartner
Publikováno v:
Molecular and Cellular Pediatrics, Vol 10, Iss 1, Pp 1-8 (2023)
Abstract Background Clinical studies suggest that female sex plays a protective role in the development and progression of kidney disease. Recent experimental studies indicate that in male rats early nephron loss under ongoing nephrogenesis is accomp
Externí odkaz:
https://doaj.org/article/06aad25ad4334c3d9e30a7f5a2266d11
Autor:
Verónica Miguel, Rafael Kramann
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1154-1163 (2023)
Fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of chronic kidney disease (CKD). Myofibroblasts, which are the cells responsible for ECM production, are activated by cross talk with injured proximal tubule and
Externí odkaz:
https://doaj.org/article/f2616024695f4d6a9a214ac1bd2aa9e3
Autor:
Verónica Miguel, Alba Rojo
Publikováno v:
Oxygen, Vol 3, Iss 3, Pp 300-321 (2023)
Chronic kidney disease (CKD) affects 10% of the population. Fibrosis is the hallmark of CKD, which is marked by the deposit of extracellular matrix (ECM). This response is the final outcome of an unbalanced reaction to inflammation and wound healing
Externí odkaz:
https://doaj.org/article/04858d0534e541ee9a9bb4a6544d1af8