Zobrazeno 1 - 10
of 1 132
pro vyhledávání: '"katG"'
Autor:
Pathom Karaipoom, Phirabhat Saengsawang, Arisa Bromnavej, Supattra Sangsong, Pinkamon Waseewiwat, Bunrit Bunsanong, Veeranoot Nissapatorn, Maria de Lourdes Pereira, Watcharapong Mitsuwan
Publikováno v:
Veterinary World, Vol 17, Iss 6, Pp 1405-1412 (2024)
Background and Aim: Mycobacterium tuberculosis causes global concern with tuberculosis (TB). Multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) pose additional challenges, as they resist multiple first-line drugs. This study i
Externí odkaz:
https://doaj.org/article/57e88adca3a14cbcaeaab90fbb084ae1
Autor:
Samaneh Saedi, kiarash ghazvini, Masoud Youssefi, Hadi Safdar, saman soleimanpour, Parviz Afrough, Amir Azimian, hamid solgi, Masoud Keikha
Publikováno v:
Reviews in Clinical Medicine, Vol 11, Iss 1, Pp 8-12 (2024)
AbstractBackground: Mycobacterium tuberculosis is still one of the most dangerous human pathogens. Identification of the relationships between different clinical strains has remained a high priority for epidemiology research. Methods: In this study,
Externí odkaz:
https://doaj.org/article/25ebfe0eab294cffab9d9d1eb5d6d485
Publikováno v:
Chronic Diseases Journal, Vol 12, Iss 2, Pp 93-101 (2024)
BACKGROUND: Isoniazid (INH) is one of the first-line drugs used for the treatment of Mycobacterium tuberculosis (Mtb). This study aimed to determine the mutations in katG and inhA promoter regions associated with INH resistance in clinical isolates o
Externí odkaz:
https://doaj.org/article/bfc6bdf63d61466e970b9383ae56ce61
Autor:
Dương Thế Long, Trần Ngọc Dung, Dương Thị Loan, Đinh Thị Hương Trúc, Trịnh Thị Hồng Của, Phạm Đắc Lộc, Nguyễn Hữu Thành, Đỗ Tấn Khang
Publikováno v:
Tạp chí Khoa học Đại học Cần Thơ, Vol 60, Iss 2 (2024)
Sự xuất hiện của bệnh lao đa kháng thuốc (MDR-TB) đã gây khó khăn trong kiểm soát bệnh lao, và việc chẩn đoán kịp thời MDR-TB là một thách thức đáng chú ý. Mục tiêu nghiên cứu là xác định đặc
Externí odkaz:
https://doaj.org/article/e0c142da253e4d2ea0632111dcda7968
Publikováno v:
Frontiers in Public Health, Vol 12 (2024)
PurposeThis study examined the patterns and frequency of genetic changes responsible for resistance to first-line (rifampicin and isoniazid), fluoroquinolones, and second-line injectable drugs in drug-resistant Mycobacterium tuberculosis (MTB) isolat
Externí odkaz:
https://doaj.org/article/3b8bf680b67f48d2a28e5dccc57854e9
Autor:
Gregory A. Harrison, Erin R. Wang, Kevin Cho, Yassin Mreyoud, Souvik Sarkar, Fredrik Almqvist, Gary J. Patti, Christina L. Stallings
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Of the approximately 10 million cases of Mycobacterium tuberculosis (Mtb) infections each year, over 10% are resistant to the frontline antibiotic isoniazid (INH). INH resistance is predominantly caused by mutations that decrease the activit
Externí odkaz:
https://doaj.org/article/6376d9c665324f819f24fe9e4bf3fa83
Autor:
Brenda Uribe-Vázquez, Adelaida Díaz-Vilchis, Aylin Avila-Linares, Gloria Saab-Rincón, Yerli Marín-Tovar, Humberto Flores, Nina Pastor, Guillermo Huerta-Miranda, Enrique Rudiño-Piñera, Xavier Soberón
Publikováno v:
Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101649- (2024)
Mycobacterium tuberculosis catalase-peroxidase (Mt-KatG) is a bifunctional heme-dependent enzyme that has been shown to activate isoniazid (INH), the widely used antibiotic against tuberculosis (TB). The L333V-KatG variant has been associated with IN
Externí odkaz:
https://doaj.org/article/c5c7dfc6325148b8919cf6179ad60b76
Autor:
Senamile Lale Ngema, Navisha Dookie, Rubeshan Perumal, Louansha Nandlal, Nikita Naicker, Marothi Peter Letsoalo, Max O'Donnell, Azraa Khan, Nesri Padayatchi, Kogieleum Naidoo
Publikováno v:
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 33, Iss , Pp 100387- (2023)
Background: High-dose isoniazid is recommended in the 9–12 months short-course regimen for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient evidence to support the assumption of genotypic-phenotypic concordance. T
Externí odkaz:
https://doaj.org/article/fe88dae6804f4416bfb74e76f780b153
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Fifteen 1,2,4-triazole derivatives were synthesised in this study and their MIC values against Mycobacterium tuberculosis (Mtb) ranged from 2 to 32 μg/mL. Furthermore, their antimycobacterial activity was positively correlated with the KatG enzyme d
Externí odkaz:
https://doaj.org/article/dfb6275a3e4142128e771beb16edc91d
Publikováno v:
Bangabandhu Sheikh Mujib Medical University Journal, Vol 16, Iss 3 (2023)
Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study
Externí odkaz:
https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e