Zobrazeno 1 - 10
of 28
pro vyhledávání: '"karyotype heterogeneity"'
Publikováno v:
Molecular Cytogenetics, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract Background HAP1, a near-haploid human leukemic cancer cell line is often used in combination with CRISPR-Cas9 gene editing technology for genetic screens. HAP1 carries the Philadelphia chromosome (Ph) and an additional ~ 30 Mb fragment of ch
Externí odkaz:
https://doaj.org/article/9e02823e9e8c462a8db1dd7f5ad54a37
Publikováno v:
Molecular Cytogenetics, Vol 14, Iss 1, Pp 1-12 (2021)
Abstract Background Chinese hamster ovary cell lines, also known as CHO cells, represent a large family of related, yet quite different, cell lines which are metabolic mutants derived from the original cell line, CHO-ori. Dihydrofolate reductase-defi
Externí odkaz:
https://doaj.org/article/cf9661a9d8df4fc0a96369136055d534
Autor:
Baudoin, Nicolaas C.
Tetraploidy – the presence of four copies of the haploid chromosome complement – is common in cancer. There is evidence that ~40% of tumors pass through a tetraploid stage at some point during their development, and tetraploid cells injected in m
Externí odkaz:
http://hdl.handle.net/10919/107005
Autor:
Floris Foijer, Lee A Albacker, Bjorn Bakker, Diana C Spierings, Ying Yue, Stephanie Z Xie, Stephanie Davis, Annegret Lutum-Jehle, Darin Takemoto, Brian Hare, Brinley Furey, Roderick T Bronson, Peter M Lansdorp, Allan Bradley, Peter K Sorger
Publikováno v:
eLife, Vol 6 (2017)
Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage. CIN
Externí odkaz:
https://doaj.org/article/c794fbef09094ecd935bc32716b160f2
Akademický článek
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Autor:
Baudoin, Nicolaas Cornelis
Tetraploidy – the presence of four copies of the haploid chromosome complement – is common in cancer. There is evidence that ~40% of tumors pass through a tetraploid stage at some point during their development, and tetraploid cells injected in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2485::ec44be685222678b31c0240cb6369115
https://hdl.handle.net/10919/107005
https://hdl.handle.net/10919/107005
Akademický článek
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Autor:
Lee A. Albacker, Roderick T. Bronson, Darin Takemoto, Diana C.J. Spierings, Floris Foijer, Brian Hare, Ying Yue, Peter K. Sorger, Stephanie Z. Xie, Stephanie H. Davis, Bjorn Bakker, Peter M. Lansdorp, Brinley Furey, Allan Bradley, Annegret Lutum-Jehle
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife, 6:20873. ELIFE SCIENCES PUBLICATIONS LTD
eLife
eLife, 6:20873. ELIFE SCIENCES PUBLICATIONS LTD
Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage. CIN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ac4c47833cf4abbbd2b2bfb9b58121
https://elifesciences.org/articles/20873
https://elifesciences.org/articles/20873
Autor:
Tristan V. de Jong, Maria Colomé-Tatché, Diana C.J. Spierings, David Porubsky, Nancy Halsema, Mirjam E. Belderbos, Allan Bradley, Victor Guryev, Peter M. Lansdorp, Eveline S. J. M. de Bont, Hinke G. Kazemier, Floris Foijer, Aaron Taudt, Karina Hoekstra-Wakker, Anke van den Berg, Bjorn Bakker
Publikováno v:
Genome Biology, 17(1):115. BMC
Genome Biol. 17:115 (2016)
Genome Biology, 17. BioMed Central
Europe PubMed Central
Genome Biology
Genome Biol. 17:115 (2016)
Genome Biology, 17. BioMed Central
Europe PubMed Central
Genome Biology
Background Chromosome instability leads to aneuploidy, a state in which cells have abnormal numbers of chromosomes, and is found in two out of three cancers. In a chromosomal instable p53 deficient mouse model with accelerated lymphomagenesis, we pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb4058d3e1fc2c98fb55762e7d338f0
https://research.rug.nl/en/publications/1c775f9f-0f53-4e4e-aa10-bf7595cf18db
https://research.rug.nl/en/publications/1c775f9f-0f53-4e4e-aa10-bf7595cf18db
Akademický článek
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