Zobrazeno 1 - 10
of 233
pro vyhledávání: '"karen leroy"'
Autor:
Hang Phuong Pham, Diane Damotte, Stéphanie Corgnac, Ludger Johannes, Eric Tartour, Léa Paolini, Fathia Mami-Chouaib, Karen Leroy, Pascaline Boudou-Rouquette, Helene Blons, Francois Goldwasser, Pierre Laurent-Puig, Isabelle Cremer, Milena Hasan, Thi Tran, Nadege Gruel, Laure Gibault, Elizabeth Fabre, Marie Wislez, Patrice Ravel, Valentin Quiniou, Jennifer Arrondeau, Aziza Caidi, Jean-Philippe Villemin, Jonathan Ulmer, Louis-Victorien Vieillard, Joséphine Pineau, Alain Gey, Pierre Barennes, Valentina Libri, Sebastien Mella, Sixtine De Percin, Hortense De Saint Basile
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 12 (2024)
Background A high density of resident memory T cells (TRM) in tumors correlates with improved clinical outcomes in immunotherapy-treated patients. In most clinical studies, TRM are defined by the CD103 marker. However, it is clearly established that
Externí odkaz:
https://doaj.org/article/e5b6260f3caa4e0bb90751e2a17c334d
Autor:
Jeremy Slomka, Hugo Berthou, Audrey Mansuet-Lupo, Hélène Blons, Elizabeth Fabre, Ivan Lerner, Bastien Rance, Marco Alifano, Jeanne Chapron, Gary Birsen, Laure Gibault, Jennifer Arrondeau, Karen Leroy, Marie Wislez
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0307161 (2024)
ObjectiveRecent evidence suggests that elevated levels of PD-L1 expression may be linked to early resistance to TKI and reduced survival in NSCLC with EGFR mutations. This study aimed to characterize the clinical and molecular features of EGFR-mutate
Externí odkaz:
https://doaj.org/article/ab6f3588f8cc47caa87e83f6b1a1c71b
Autor:
Christophe Bontoux MD, Alice Guyard MD, Audrey Lupo MD, PhD, Karim Diallo MSc, Khedidja Rebah MD, Agathe Hercent MD, Edouard Guenzi MD, Jérome Cros MD, PhD, Jérome Lamoril MD, Karen Leroy PharmD, PhD, Nathalie Theou-Anton PharmD, PhD
Publikováno v:
Cancer Control, Vol 30 (2023)
Introduction Gene copy number variations have theranostic impact and require reliable methods for their identification. We aimed to evaluate the reliability of combined next-generation sequencing (NGS) and digital droplet PCR (ddPCR) method for gene
Externí odkaz:
https://doaj.org/article/f0703602648c4d0ab577fb36948d1780
Autor:
Karen Leroy, Clarisse Audigier Valette, Jérôme Alexandre, Lise Boussemart, Jean Chiesa, Clotilde Deldycke, Carlos Gomez-Rocca, Antoine Hollebecque, Jacqueline Lehmann-Che, Antoinette Lemoine, Sandrine Mansard, Jacques Medioni, Isabelle Monnet, Samia Mourah, Thomas Pierret, Dominique Spaëth, Alexandre Civet, Sandrine Galoin, Antoine Italiano
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291495 (2023)
IntroductionConsidering the growing interest in matched cancer treatment, our aim was to evaluate the ability of a comprehensive genomic profiling (CGP) assay to propose at least one targeted therapy given an identified genomic alteration or signatur
Externí odkaz:
https://doaj.org/article/8bec3a2beb214f7a869dd1f1edcdeb6c
Autor:
Raphaël Borie, Valérie Caro, Hilario Nunes, Marianne Kambouchner, Aurélie Cazes, Martine Antoine, Bruno Crestani, Karen Leroy, Christiane Copie-Bergman, Aurelia Kwasiborski, Christophe Hennequin, Mathias Vandenbogaert, Véronique Hourdel, Jacques Cadranel
Publikováno v:
Infectious Agents and Cancer, Vol 16, Iss 1, Pp 1-4 (2021)
Abstract Mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with chronic antigen stimulation: auto-antigens or of microbial origin. Only one study suggested association between Achromobacter xylosoxidans and pulmonary MALT lymp
Externí odkaz:
https://doaj.org/article/a14ac31298cd4ecea4cb8ce2f21bebbf
Autor:
Diane Damotte, Sarah Warren, Jennifer Arrondeau, Pascaline Boudou-Rouquette, Audrey Mansuet-Lupo, Jérôme Biton, Hanane Ouakrim, Marco Alifano, Claire Gervais, Audrey Bellesoeur, Nora Kramkimel, Camille Tlemsani, Barbara Burroni, Angéline Duche, Franck Letourneur, Han Si, Rebecca Halpin, Todd Creasy, Ronald Herbst, Xing Ren, Pascale Morel, Alessandra Cesano, François Goldwasser, Karen Leroy
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background The 18-gene tumor inflammation signature (TIS) is a clinical research assay that enriches for clinical benefit to immune checkpoint blockade. We evaluated its ability to predict clinical benefit of immunotherapy in cancer patients
Externí odkaz:
https://doaj.org/article/b75c5fd83d2d4639a48bed140c36dd2f
Autor:
Sydney Dubois, Bruno Tesson, Sylvain Mareschal, Pierre-Julien Viailly, Elodie Bohers, Philippe Ruminy, Pascaline Etancelin, Pauline Peyrouze, Christiane Copie-Bergman, Bettina Fabiani, Tony Petrella, Jean-Philippe Jais, Corinne Haioun, Gilles Salles, Thierry Jo Molina, Karen Leroy, Hervé Tilly, Fabrice Jardin
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 58-69 (2019)
Background: Gene expression profiling (GEP), next-generation sequencing (NGS) and copy number variation (CNV) analysis have led to an increasingly detailed characterization of the genomic profiles of DLBCL. The aim of this study was to perform a full
Externí odkaz:
https://doaj.org/article/caebab5f1252465bacdc086f8e883197
Autor:
Camille Tlemsani, Nicolas Pécuchet, Aurelia Gruber, Ingrid Laurendeau, Claire Danel, Marc Riquet, Françoise Le Pimpec‐Barthes, Elizabeth Fabre, Audrey Mansuet‐Lupo, Diane Damotte, Marco Alifano, Armelle Luscan, Benoit Rousseau, Dominique Vidaud, Jennifer Varin, Beatrice Parfait, Ivan Bieche, Karen Leroy, Pierre Laurent‐Puig, Benoit Terris, Helene Blons, Michel Vidaud, Eric Pasmant
Publikováno v:
Cancer Medicine, Vol 8, Iss 9, Pp 4330-4337 (2019)
Abstract The tumor suppressor gene neurofibromin 1 (NF1) is a major regulator of the RAS‐MAPK pathway. NF1 mutations occur in lung cancer but were not extensively explored. We hypothesized that NF1‐mutated tumors could define a specific populatio
Externí odkaz:
https://doaj.org/article/1a977a17d1364953847cb9500545d65d
Autor:
Alice Guyard, Cécile Charpy, Nathalie Théou-Anton, Anne Cremades, Frédéric Grassin, Anaïs Bourgogne, Karen Leroy, Anaïs Pujals, Christiane Copie-Bergman, Christos Chouaid, Audrey Mansuet-Lupo
Publikováno v:
Translational Oncology, Vol 12, Iss 5, Pp 784-787 (2019)
Anaplastic lymphoma kinase (ALK) rearrangement is reported in 3% to 8% of patients with lung adenocarcinoma and can be detected by fluorescent in situ hybridization (FISH) or indirectly by immunohistochemistry. In FISH assay, isolated 5′ signal (lo
Externí odkaz:
https://doaj.org/article/417e1885bac74146a6c2267bde74831b
Autor:
Nathalie Faumont, Oussama Taoui, Davi Collares, Jean-Philippe Jais, Karen Leroy, Léa Prévaud, Fabrice Jardin, Thierry J. Molina, Christiane Copie-Bergman, Barbara Petit, Marie-Pierre Gourin, Dominique Bordessoule, Danielle Troutaud, Véronique Baud, Jean Feuillard
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Relationships between c-Rel and GCB-DLBCLs remain unclear. We found that strong c-Rel DNA-binding activity was mostly found in GCBs on two independent series of 48 DLBCLs and 66 DLBCLs, the latter issued from the GHEDI series. c-Rel DNA-binding activ
Externí odkaz:
https://doaj.org/article/cc5e9e2c17bf4d2bb3dc4179c7dae410