Zobrazeno 1 - 10
of 10
pro vyhledávání: '"julien Vantourout"'
Autor:
Camille Rubel, Yilin Cao, Tamara El-Hayek Ewing, Gabriele Laudadio, Gregory Beutner, Steven Wisniewski, Xiangyu Wu, Phil Baran, Julien Vantourout, Keary Engle
Over the last fifty years, the use of nickel catalysts for facilitating organic transformations has skyrocketed. Ni(0) sources act as useful precatalysts because they can enter a catalytic cycle through ligand exchange, without needing to undergo add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d5c82ac6948dfc97be5fcd0b8667da
https://doi.org/10.26434/chemrxiv-2023-sgnl1
https://doi.org/10.26434/chemrxiv-2023-sgnl1
Because internal alkenes are more challenging synthetic targets than terminal alkenes, metal-catalyzed olefin trans-position (i.e., positional isomerization) approaches have emerged to afford valuable E- or Z- internal alkenes from their complementar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478f7688a7b26e21c76481f7f8130abd
https://doi.org/10.26434/chemrxiv-2022-x8ssk
https://doi.org/10.26434/chemrxiv-2022-x8ssk
Autor:
Taline Kerackian, Didier Bouyssi, Guillaume Pilet, Maurice Médebielle, Nuno Monteiro, Julien Vantourout, Abderrahmane Amgoune
The development and in-depth study of a novel catalytic method relying on the combination of nickel catalysis and electrochemistry for the cross-electrophile coupling of alkyl amides with alkyl halides is described. This methodology takes advantages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42efc0806ff859d5c973c5dbb0bf3c67
https://doi.org/10.26434/chemrxiv-2022-mbqs6
https://doi.org/10.26434/chemrxiv-2022-mbqs6
Autor:
Yu Kawamata, Keun Ah Ryu, Gary Hermann, Alexander Sandahl, Julien Vantourout, Aleksandra Olow, La-Tonya Adams, Eva Rivera-Chao, Lee Roberts, Rob Oslund, Olugbeminiyi Fadeyi, phil baran
Target identification is a critical pillar within the drug discovery process that involves deconvoluting the protein target of a pharmacologically active small molecule ligand. While photoaffinity labeling strategies have become the benchmark for tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06e9180b77d091b52a2f118230574b3
https://doi.org/10.26434/chemrxiv-2022-s2m8f
https://doi.org/10.26434/chemrxiv-2022-s2m8f
Autor:
phil baran, Michał Ociepa, Kyle Knouse, David He, Julien Vantourout, Dillon Flood, Natalia Padial, Jason Chen, Brittany Sanchez, Emily Sturgell, Bin Zheng, Shenjie Qiu, Michael Schmidt, Martin Eastgate
An operationally simple, scalable, and chemoselective method for the direct phosphorylation of alcohols using a P(V)-approach based on the PSI-reagent platform is disclosed. The method features a broad substrate scope of utility in both simple and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6488d5470879c0040cd4e86048272f3a
https://doi.org/10.26434/chemrxiv-2021-4ksng
https://doi.org/10.26434/chemrxiv-2021-4ksng
Autor:
Yang Gao, david hill, wei hao, Brendon J. McNicholas, julien Vantourout, Ryan Hadt, Sarah Reisman, Donna Blackmond, Phil Baran
One of the most oft-employed methods for C–C bond formation involving the coupling of vinyl-halides with aldehydes catalyzed by Ni and Cr (Nozaki–Hiyama–Kishi, NHK) has been rendered more practical using an electroreductive manifold. Although e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fade3b867b5b0065c8d9988f015ae7
https://doi.org/10.26434/chemrxiv.14251787
https://doi.org/10.26434/chemrxiv.14251787
Autor:
Thomas McGuire, Alexandra Slawin, David Cordes, Bela Bode, sonia chabbra, Jeremy Brals, Julien Vantourout, James Fyfe, Chao Xu, Nicola Bell, Allan Watson
Metal-catalyzed C–N cross-coupling generally forms C–N bonds by reductive elimination from metal complexes bearing covalent C- and N-ligands. We have identified a Cu-mediated C–N cross-coupling that uses a dative N-ligand in the bond forming ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc3b17c4ef01173b923297efc0185e7
https://doi.org/10.26434/chemrxiv.13399307
https://doi.org/10.26434/chemrxiv.13399307
Autor:
Phil Baran, Shelley D. Minteer, Pierre-Georges Echeverria, Lucas Mele, Jinjun Li, Pan Wang, Julien Vantourout, Christian A. Malapit, Byron Peters, Pengfei Hu
A user-friendly approach to sidestep the venerable Grignard addition to unactivated ketones to access tertiary alcohols by reversing the polarity of the disconnection. In this work a ketone instead acts as a nucleophile when adding to simple unactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c568be43ffecf64f16b8f5ea7eb065a6
https://doi.org/10.26434/chemrxiv.13139510
https://doi.org/10.26434/chemrxiv.13139510
Autor:
Philipp M. Holstein, David Dailler, Julien Vantourout, Janah Shaya, Anthony Millet, Olivier Baudoin
Publikováno v:
Angewandte Chemie. 128:2855-2859
A variety of strained α-alkylidene-γ-lactams were synthesized by palladium(0)-catalyzed intramolecular C(sp3)−H alkenylation from easily accessible acyclic and monocyclic bromoalkene precursors. These lactams are valuable intermediates for access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dc2b0ddfcc7f1d7b750936b6d398de
https://doi.org/10.1002/ange.201511457
https://doi.org/10.1002/ange.201511457
Autor:
Marek M, Nagiec, Jeremy R, Duvall, Adam P, Skepner, Eleanor A, Howe, Jessica, Bastien, Eamon, Comer, Jean-Charles, Marie, Stephen E, Johnston, Joseph, Negri, Michelle, Eichhorn, Julien, Vantourout, Clary, Clish, Kiran, Musunuru, Michael, Foley, Jose R, Perez, Michelle A J, Palmer
Publikováno v:
MedChemComm. 9(11)
Increased expression of the Tribbles pseudokinase 1 gene (TRIB1) is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary artery disease and myocardial infarction. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22e105aa4f33d9ef4ee264e0519ebeba
https://pubmed.ncbi.nlm.nih.gov/30542533
https://pubmed.ncbi.nlm.nih.gov/30542533