Zobrazeno 1 - 10 of 377 pro vyhledávání: '"joseph elborn"'
1
Guiding the rational design of patient-centred drug trials in Cystic Fibrosis: A Delphi study
Autor: Susan Madge, Joseph Elborn, Jane C. Davies, L. Allen, Frank Kee, T. Purcell, Clare Saunders, Marco Boeri, S. Goundry, R. Dobra
Publikováno v: Journal of Cystic Fibrosis. 20:986-993
Background Making trials more patient-centred improves recruitment and retention, patient satisfaction and makes research accessible to a more representative population. We aimed to understand the factors that influence participation and engagement i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40165b80a4f04a18511977ebaa17c72a
https://doi.org/10.1016/j.jcf.2021.03.021
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2
Cystic fibrosis drug trial design in the era of CFTR modulators associated with substantial clinical benefit: stakeholders’ consensus view
Autor: K. De Boeck, Isabelle Fajac, Margarida D. Amaral, Eitan Kerem, Pavel Drevinek, Joseph Elborn, T. Lee, Jane C. Davies
Publikováno v: Journal of Cystic Fibrosis. 19:688-695
CFTR modulators associated with substantial clinical benefit are expected to rapidly improve the baseline condition of people with cystic fibrosis (PWCF) as well as decrease the rate of lung function decline, the occurrence of pulmonary exacerbations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5db031fd96ab6c53a3d7108263d236a1
https://doi.org/10.1016/j.jcf.2020.05.012
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3
P130 Pseudomonas aeruginosa impairs growth of aspergillus from CF airway samples
Autor: William O.C.M. Cookson, DA Hughes, M Coates, Leah Cuthbertson, I.C. Felton, Henry Price, Nicholas J. Simmonds, Joseph Elborn, Darius Armstrong-James, Loebinger, Miriam F. Moffatt, Jane C. Davies
Publikováno v: Chronic suppurative lung disease in adults and children.
Objectives Fungal infection is associated with poor lung health in CF but may go undetected. The low sensitivity of standard fungal culture is well recognised but poorly understood. Pseudomonas aeruginosa (Pa) has been shown to inhibit growth of Aspe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73948473e4e23ae14e10da89d5d7e5b5
https://doi.org/10.1136/thorax-2020-btsabstracts.275
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4
T6 Sputum proteomics identifies mechanisms of disease severity and treatment response in bronchiectasis
Autor: Stefano Aliberti, Guillermo Suarez-Cuartin, Amelia Shoemark, Megan Crichton, Jennifer Pollock, Ashley Giam, Gisli G. Einarsson, Elizabeth Furrie, Christopher J. Fong, James D. Chalmers, Thomas C. Fardon, Jeffrey T.-J. Huang, Joseph Elborn, Andrew Cassidy, Alison Dicker, Simon Finch, Holly R. Keir, Oriol Sibila
Publikováno v: BTS/BALR/BLF Early Career Investigator Awards.
Introduction Neutrophil extracellular traps (NETs) are a form of antimicrobial defence which have been implicated in multiple inflammatory diseases. This study investigated the role of NETs in bronchiectasis, a neutrophilic disease which lacks therap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb6ff294f31427574ee110fde5a88dab
https://doi.org/10.1136/thorax-2020-btsabstracts.6
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6
Bronchiectasis: Treatment decisions for pulmonary exacerbations and their prevention
Autor: Scott C. Bell, Joseph Elborn, Catherine A. Byrnes
Publikováno v: Respirology. 23:1006-1022
Interest in bronchiectasis has increased over the past two decades, as shown by the establishment of disease-specific registries in several countries, the publication of management guidelines and a growing number of clinical trials to address evidenc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::900ecc5135c6ee60657504c9b69f5bff
https://doi.org/10.1111/resp.13398
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7
Current and emerging comorbidities in cystic fibrosis
Autor: Joseph Elborn, Barry J. Plant, N.J. Ronan
Publikováno v: La Presse Médicale. 46:e125-e138
Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed ubiquitously throughout the body. Thus, while respiratory manifestations dominate much of cystic fibrosis (CF) care, there are prominent multi-organ manifestations and comorbidit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db67b49e06c45c46d84e1407352f231e
https://doi.org/10.1016/j.lpm.2017.05.011
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8
The effect of increased fruit and vegetable consumption on selected macronutrient and micronutrient intakes in four randomised-controlled trials
Autor: David R. McCance, Jayne V. Woodside, Joseph Elborn, Ciara Mulligan, Michelle C. McKinley, J. D. Edgar, Christopher Patterson, Ian S. Young, Charlotte E. Neville, Sharon L Fulton, Francina R. Baldrick, D. McCall
Publikováno v: Fulton, S L, McKinley, M C, Neville, C E, Baldrick, F R, Mulligan, C, McCall, D O, McCance, D R, Edgar, J D, Elborn, J S, Young, I S, Patterson, C C & Woodside, J V 2017, ' The effect of increased fruit and vegetable consumption on selected macronutrient and micronutrient intakes in four randomised-controlled trials ', The British journal of nutrition, vol. 117, no. 9, pp. 1270-1278 . https://doi.org/10.1017/S0007114517001088
Fruit and vegetable (FV) intake is associated with reduced risk of a number of non-communicable diseases. Research tends to focus on antioxidants, flavonoids and polyphenols contained in FV as the main beneficial components to health; however, increa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb946be6678079f5d09fc7c306acdc9
https://doi.org/10.1017/s0007114517001088
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