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Akademický článek

Analytical validation of the 7-gene biosignature for prediction of recurrence risk and radiation therapy benefit for breast ductal carcinoma in situ

Autor: David Dabbs, Karuna Mittal, Scott Heineman, Pat Whitworth, Chirag Shah, Jess Savala, Steven C. Shivers, Troy Bremer

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

PurposeDuctal carcinoma in situ (DCIS), is a noninvasive breast cancer, representing 20-25% of breast cancer diagnoses in the USA. Current treatment options for DCIS include mastectomy or breast-conserving surgery (BCS) with or without radiation ther

Externí odkaz: https://doaj.org/article/1260463047244c51a7b2f22c461a7cf4

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Data from A Biological Signature for Breast Ductal Carcinoma In Situ to Predict Radiotherapy Benefit and Assess Recurrence Risk

Autor: Fredrik Wärnberg, Rose-Marie Amini, Wenjing Zhou, Karin Jirström, Steven P. Linke, Glen Leesman, Stephen Lyle, Todd Barry, Jess Savala, Rakesh Patel, Pat W. Whitworth, Troy Bremer

Purpose:Ductal carcinoma in situ (DCIS) patients and their physicians currently face challenging treatment decisions with limited information about the individual's subsequent breast cancer risk or treatment benefit. The DCISionRT biological signatur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d0acb9902649cfd36a825ddb6c1a7b
https://doi.org/10.1158/1078-0432.c.6527298.v1

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A Novel Biosignature Identifies Patients With DCIS With High Risk of Local Recurrence After Breast Conserving Surgery and Radiation Therapy

Autor: Frank A. Vicini, G. Bruce Mann, Chirag Shah, Sheila Weinmann, Michael C. Leo, Pat Whitworth, Rachel Rabinovitch, Mylin A. Torres, Julie A. Margenthaler, David Dabbs, Jess Savala, Steven C. Shivers, Karuna Mittal, Fredrik Wärnberg, Troy Bremer

Publikováno v: International journal of radiation oncology, biology, physics. 115(1)

There is an unmet need to identify women diagnosed with ductal carcinoma in situ (DCIS) with a low risk of in-breast recurrence (IBR) after breast conserving surgery (BCS), which could omit radiation therapy (RT), and also to identify those with elev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286b63a485d9d1f65118381eb7aa3b09
https://pubmed.ncbi.nlm.nih.gov/36115740

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Abstract P2-08-57: A biologic signature to predict ipsilateral breast event risk at 10 years for early breast cancer

Autor: Pat Whitworth, Troy Bremer, Charlotta Wadsten, Glen Leesman, Malin Sund, Fredrik Wärnberg, Jess Savala

Publikováno v: Cancer Research. 79:P2-08

Background Outcomes for women with early breast cancer have continually improved. A biologic signature to identify those patients that have elevated ipsilateral breast event (IBE) risk after breast conserving surgery (BCS) treated with or without rad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fc847391c146c122a8a511c47f7d2e9
https://doi.org/10.1158/1538-7445.sabcs18-p2-08-57

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Assessing the benefit of adjuvant endocrine therapy in patients following breast-conserving surgery with or without radiation stratified by a 7-gene predictive DCIS biosignature

Autor: Pat W. Whitworth, Chirag S. Shah, Frank A. Vicini, Rachel Rabinovitch, Julie A. Margenthaler, Fredrik Warnberg, Brian J. Czerniecki, Michael C. Leo, Sheila Weinmann, Bruce Mann, David J. Dabbs, Jess Savala, Steven C. Shivers, Karuna Mittal, Troy Bremer

Publikováno v: Journal of Clinical Oncology. 40:502-502

502 Background: Breast conserving surgery (BCS) followed by radiotherapy (RT) has been the mainstay for DCIS treatment. Adjuvant endocrine therapy (ET) has often been recommended based on multiple randomized clinical trials (RCT). However, these stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09cf76cc547f5ddc64ca40059582e022
https://doi.org/10.1200/jco.2022.40.16_suppl.502

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